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IUBMB Comments The enzyme, characterized from agarose-degrading bacteria, is involved in a degradation pathway for 3,6-anhydro-α-L -galactopyranose, a major component of the polysaccharides of red macroalgae.
The enzyme appears in viruses and cellular organisms
Synonyms 2-keto-3-deoxy-L-galactonate 5-dehydrogenase, more
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2-keto-3-deoxy-L-galactonate 5-dehydrogenase
2-keto-3-deoxy-L-galactonate 5-dehydrogenase
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2-keto-3-deoxy-L-galactonate 5-dehydrogenase
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2-keto-3-deoxy-L-galactonate 5-dehydrogenase
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2-keto-3-deoxy-L-galactonate 5-dehydrogenase
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2-keto-3-deoxy-L-galactonate 5-dehydrogenase
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2-keto-3-deoxy-L-galactonate 5-dehydrogenase
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2-dehydro-3-deoxy-L-galactonate + NAD+ = 3-deoxy-D-glycero-2,5-hexodiulosonate + NADH + H+
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MetaCyc
3,6-anhydro-alpha-L-galactopyranose degradation
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2-dehydro-3-deoxy-L-galactonate:NAD+ 5-oxidoreductase
The enzyme, characterized from agarose-degrading bacteria, is involved in a degradation pathway for 3,6-anhydro-alpha-L-galactopyranose, a major component of the polysaccharides of red macroalgae.
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2-dehydro-3-deoxy-L-galactonate + NAD+
2,5-didehydro-3-deoxy-L-galactonate + NADH + H+
additional information
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Substrates: no activity with 2-dehydro-3-deoxy-D-galactonate Products: -
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2-dehydro-3-deoxy-L-galactonate + NAD+
2,5-didehydro-3-deoxy-L-galactonate + NADH + H+
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Substrates: - Products: -
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2-dehydro-3-deoxy-L-galactonate + NAD+
2,5-didehydro-3-deoxy-L-galactonate + NADH + H+
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Substrates: - Products: -
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2-dehydro-3-deoxy-L-galactonate + NAD+
2,5-didehydro-3-deoxy-L-galactonate + NADH + H+
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Substrates: - Products: -
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2-dehydro-3-deoxy-L-galactonate + NAD+
2,5-didehydro-3-deoxy-L-galactonate + NADH + H+
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Substrates: - Products: -
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2-dehydro-3-deoxy-L-galactonate + NAD+
2,5-didehydro-3-deoxy-L-galactonate + NADH + H+
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Substrates: - Products: -
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2-dehydro-3-deoxy-L-galactonate + NAD+
2,5-didehydro-3-deoxy-L-galactonate + NADH + H+
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Substrates: - Products: -
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2-dehydro-3-deoxy-L-galactonate + NAD+
2,5-didehydro-3-deoxy-L-galactonate + NADH + H+
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Substrates: - Products: -
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2-dehydro-3-deoxy-L-galactonate + NAD+
2,5-didehydro-3-deoxy-L-galactonate + NADH + H+
additional information
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Substrates: no activity with 2-dehydro-3-deoxy-D-galactonate Products: -
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2-dehydro-3-deoxy-L-galactonate + NAD+
2,5-didehydro-3-deoxy-L-galactonate + NADH + H+
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Substrates: - Products: -
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2-dehydro-3-deoxy-L-galactonate + NAD+
2,5-didehydro-3-deoxy-L-galactonate + NADH + H+
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Substrates: - Products: -
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2-dehydro-3-deoxy-L-galactonate + NAD+
2,5-didehydro-3-deoxy-L-galactonate + NADH + H+
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Substrates: - Products: -
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2-dehydro-3-deoxy-L-galactonate + NAD+
2,5-didehydro-3-deoxy-L-galactonate + NADH + H+
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Substrates: - Products: -
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2-dehydro-3-deoxy-L-galactonate + NAD+
2,5-didehydro-3-deoxy-L-galactonate + NADH + H+
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Substrates: - Products: -
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2-dehydro-3-deoxy-L-galactonate + NAD+
2,5-didehydro-3-deoxy-L-galactonate + NADH + H+
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Substrates: - Products: -
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2-dehydro-3-deoxy-L-galactonate + NAD+
2,5-didehydro-3-deoxy-L-galactonate + NADH + H+
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Substrates: - Products: -
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NAD+
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Highest Expressing Human Cell Lines
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Cell Line Links
Gene Links
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DDGAH_PSEA6
Pseudoalteromonas atlantica (strain T6c / ATCC BAA-1087)
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36373
Swiss-Prot
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Ni-NTA column chromatography
Ni-NTA column chromatography
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Ni-NTA column chromatography
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Ni-NTA column chromatography
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expressed in Escherichia coli
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expressed in Escherichia coli BL21 CodonPlus (DE3)-RIL cells
expressed in Escherichia coli BL21 CodonPlus (DE3)-RIL cells
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expressed in Escherichia coli BL21 CodonPlus (DE3)-RIL cells
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expressed in Escherichia coli BL21 CodonPlus (DE3)-RIL cells
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Lee, S.B.; Cho, S.J.; Kim, J.A.; Lee, S.Y.; Kim, S.M.; Lim, H.S.
Metabolic pathway of 3,6-anhydro-L-galactose in agar-degrading microorganisms
Biotechnol. Bioprocess Eng.
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866-878
2014
Postechiella marina, Postechiella marina M091, Pseudoalteromonas atlantica, Pseudoalteromonas atlantica T6c, Streptomyces coelicolor, Streptomyces coelicolor A3(2)
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Lee, S.B.
Unusual metabolism of 3,6-anhydro-L-galactose in Vibrio sp. EJY3 and in E. coli containing two Vibrio sp. EJY3 genes
Biotechnol. Bioprocess Eng.
20
714-717
2015
Vibrio sp.
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