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Information on EC 1.1.1.377 - L-rhamnose 1-dehydrogenase (NADP+)
for references in articles please use BRENDA:EC1.1.1.377
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EC Tree 1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.377 L-rhamnose 1-dehydrogenase (NADP+)
IUBMB Comments
The enzyme from the archaeon Thermoplasma acidophilum is part of the non-phosphorylative degradation pathway for L-rhamnose. The enzyme differs in cofactor specificity from EC 1.1.1.173, L-rhamnose 1-dehydrogenase, which is specific for NAD+.
The expected taxonomic range for this enzyme is: Bacteria, Archaea
showSynonyms
ta0747p, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
L-rhamnose + NADP+ = L-rhamnono-1,4-lactone + NADPH + H+
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
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SYSTEMATIC NAME
IUBMB Comments
L-rhamnose:NADP+ 1-oxidoreductase
The enzyme from the archaeon Thermoplasma acidophilum is part of the non-phosphorylative degradation pathway for L-rhamnose. The enzyme differs in cofactor specificity from EC 1.1.1.173, L-rhamnose 1-dehydrogenase, which is specific for NAD+.
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-rhamnose + NADP+
L-rhamno-1,4-lactone + NADPH + H+
G3LGQ3
Substrates: -
Products: -
Products: -
?
L-rhamnose + NADP+
L-rhamno-1,4-lactone + NADPH + H+
G3LGQ3
Substrates: first enzyme of the non-phosphorylative L-rhamnose pathway in archaea
Products: -
Products: -
?
additional information
?
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G3LGQ3
Substrates: less than 1% activity is observed for D-mannose, myo-inositol, D-glyceraldehyde, and D-talose. No catalytic activity is detected for the following substrates: D-glucose, D-galactose, L-galactose, D-arabinose, L-arabinose, Dxylose, L-xylose, D-fucose, L-fucose, D-fructose, D-mannitol, D-xylitol, D-sorbitol, D-ribose, D-deoxyribose, D-glucosamine, N-acetyl-D-glucosamine, and D-altrose
Products: -
Products: -
?
additional information
?
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Substrates: less than 1% activity is observed for D-mannose, myo-inositol, D-glyceraldehyde, and D-talose. No catalytic activity is detected for the following substrates: D-glucose, D-galactose, L-galactose, D-arabinose, L-arabinose, Dxylose, L-xylose, D-fucose, L-fucose, D-fructose, D-mannitol, D-xylitol, D-sorbitol, D-ribose, D-deoxyribose, D-glucosamine, N-acetyl-D-glucosamine, and D-altrose
Products: -
Products: -
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-rhamnose + NADP+
L-rhamno-1,4-lactone + NADPH + H+
G3LGQ3
Substrates: first enzyme of the non-phosphorylative L-rhamnose pathway in archaea
Products: -
Products: -
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Highest Expressing Human Cell Lines
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
G3LGQ3
first enzyme of the non-phosphorylative L-rhamnose pathway in archaea
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). RHAD_THEAC
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
254
0
27939
Swiss-Prot
-
A0A7W8T8Q7_9BURK
260
0
27144
TrEMBL
-
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kim, S.M.; Paek, K.H.; Lee, S.B.
Characterization of NADP+-specific L-rhamnose dehydrogenase from the thermoacidophilic Archaeon Thermoplasma acidophilum.
Extremophiles
16
447-454
2012
Thermoplasma acidophilum (G3LGQ3), Thermoplasma acidophilum
brenda
EXTERNAL LINKS (specific for EC-Number 1.1.1.377)
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Release 2023.1 (January 2023)
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