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Information on EC 1.1.1.346 - 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming) and Organism(s) Pseudomonas aeruginosa

for references in articles please use BRENDA:EC1.1.1.346

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IUBMB Comments

The enzyme is involved in ketogluconate metabolism, and catalyses the reaction in vivo in the reverse direction to that shown . It is used in the commercial microbial production of ascorbate. cf. EC 1.1.1.274, 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming).

The enzyme appears in selected viruses and cellular organisms

Synonyms
25dkgr-a, 2,5-dkgr a, 2,5-diketo-d-gluconic acid reductase a, more

PATHWAY SOURCE
PATHWAYS
MetaCyc
ketogluconate metabolism, L-ascorbate biosynthesis VIII (engineered pathway)
SYSTEMATIC NAME
IUBMB Comments
2-dehydro-D-gluconate:NADP+ 2-oxidoreductase (2-dehydro-L-gulonate-forming)
The enzyme is involved in ketogluconate metabolism, and catalyses the reaction in vivo in the reverse direction to that shown [1]. It is used in the commercial microbial production of ascorbate. cf. EC 1.1.1.274, 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming).
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