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Information on EC - 4-phosphoerythronate dehydrogenase

for references in articles please use BRENDA:EC1.1.1.290
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IUBMB Comments
This enzyme catalyses a step in a bacterial pathway for the biosynthesis of pyridoxal 5'-phosphate. The enzyme contains a tightly-bound NAD(H) cofactor that is not re-oxidized by free NAD+. In order to re-oxidize the cofactor and restore enzyme activity, the enzyme catalyses the reduction of a 2-oxo acid (such as 2-oxoglutarate, oxaloacetate, or pyruvate) to the respective (R)-hydroxy acid . cf. EC, 2-oxoglutarate reductase.
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The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
erythronate-4-phosphate dehydrogenase, 4-phosphoerythronate dehydrogenase, more
4-phospho-D-erythronate + NAD+ = (3R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + NADH + H+
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