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Information on EC 1.1.1.283 - methylglyoxal reductase (NADPH)

for references in articles please use BRENDA:EC1.1.1.283

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IUBMB Comments

The enzyme from the yeast Saccharomyces cerevisiae catalyses the reduction of a keto group in a number of compounds, forming enantiopure products. Among the substrates are methylglyoxal (which is reduced to (S)-lactaldehyde) [1,2], 3-methylbutanal , hexane-2,5-dione and 3-chloro-1-phenylpropan-1-one . The enzyme differs from EC 1.1.1.78, methylglyoxal reductase (NADH), which is found in mammals, by its coenzyme requirement, reaction direction, and enantiomeric preference.

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

Synonyms
sakr1, mg reductase, nadph-dependent methylglyoxal reductase, lbuc_0522, nadph-linked aldolase reductase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(S)-lactaldehyde + NADP+ = 2-oxopropanal + NADPH + H+
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
methylglyoxal degradation IV, methylglyoxal degradation V