Disease on EC 1.1.1.270 - 3beta-hydroxysteroid 3-dehydrogenase

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DISEASE
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11beta-hydroxysteroid dehydrogenase deficiency
Epidemiologic study of adrenal gland disorders in Japan.
3(or 17)beta-hydroxysteroid dehydrogenase deficiency
Characterization of two novel homozygous missense mutations involving codon 6 and 259 of type II 3beta-hydroxysteroid dehydrogenase (3betaHSD) gene causing, respectively, nonsalt-wasting and salt-wasting 3betaHSD deficiency disorder.
Male pseudohermaphroditism consistent with 17,20-desmolase deficiency.
Masculinizing genitoplasty in intersex patients.
3-oxo-5alpha-steroid 4-dehydrogenase (acceptor) deficiency
Masculinizing genitoplasty in intersex patients.
3beta-hydroxy-delta5-steroid dehydrogenase deficiency
Carriers for type II 3beta-hydroxysteroid dehydrogenase (HSD3B2) deficiency can only be identified by HSD3B2 genotype study and not by hormone test.
3beta-hydroxysteroid 3-dehydrogenase deficiency
A new insight into the molecular basis of 3beta-hydroxysteroid dehydrogenase deficiency.
A novel A10E homozygous mutation in the HSD3B2 gene causing severe salt-wasting 3beta-hydroxysteroid dehydrogenase deficiency in 46,XX and 46,XY French-Canadians: evaluation of gonadal function after puberty.
An adrenal rest tumour in the perirenal region in a patient with congenital adrenal hyperplasia due to congenital 3beta-hydroxysteroid dehydrogenase deficiency.
Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis.
Definitive diagnosis of enzymatic deficiencies of steroidogenesis in at-risk newborns and infants by urinary marker analysis using GC/MS-SIM.
Delayed diagnosis of congenital adrenal hyperplasia with salt wasting due to type II 3beta-hydroxysteroid dehydrogenase deficiency.
Determination of 17alpha-hydroxypregnenolone in human plasma by routine isotope dilution mass spectrometry using benchtop gas chromatography-mass selective detection.
Evaluation of the tubular and interstitial functions of the testis in 46,XY patients with ambiguous genitalia.
Human 3beta-hydroxysteroid dehydrogenase deficiency associated with normal spermatic numeration despite a severe enzyme deficit.
Hydrops of placental stem villi complicated with fetal congenital adrenal hyperplasia.
Masculinizing genitoplasty in intersex patients.
Mutations in the type II 3beta-hydroxysteroid dehydrogenase (HSD3B2) gene can cause premature pubarche in girls.
New insight into the molecular basis of 3beta-hydroxysteroid dehydrogenase deficiency: identification of eight mutations in the HSD3B2 gene eleven patients from seven new families and comparison of the functional properties of twenty-five mutant enzymes.
Newly proposed hormonal criteria via genotypic proof for type II 3beta-hydroxysteroid dehydrogenase deficiency.
Plasma 17-OH pregnenolone: comparison of a time-resolved fluoroimmunoassay using a new tracer 17-OH pregnenolone-3-oxyacetyl-biotine with a radioimmunoassay using 125I 17-OH pregnenolone-3-hemisuccinate-histamine.
Prevalence of 3beta-hydroxysteroid dehydrogenase-deficient nonclassic adrenal hyperplasia in hyperandrogenic women with adrenal androgen excess.
Rapid second-tier molecular genetic analysis for congenital adrenal hyperplasia attributable to steroid 21-hydroxylase deficiency.
Refining hormonal diagnosis of type II 3beta-hydroxysteroid dehydrogenase deficiency in patients with premature pubarche and hirsutism based on HSD3B2 genotyping.
Testicular endocrine function in a pubertal boy with 3beta-hydroxysteroid dehydrogenase deficiency.
The Molecular and Clinical Spectrum of 3beta-hydroxysteroid Dehydrogenase Deficiency Disorder.
[3Beta-hydroxysteroid dehydrogenase deficiency]
[Congenital adrenal hyperplasia due to 3beta-hydroxysteroid dehydrogenase deficiency]
Acne Vulgaris
Testosterone synthesized in cultured human SZ95 sebocytes derives mainly from dehydroepiandrosterone.
Addison Disease
Epidemiologic study of adrenal gland disorders in Japan.
Adenocarcinoma
Proteomic screening of a cell line model of esophageal carcinogenesis identifies cathepsin D and aldo-keto reductase 1C2 and 1B10 dysregulation in Barrett's esophagus and esophageal adenocarcinoma.
Adenoma
Cushing's syndrome due to bilateral adrenocortical adenomas with unique histological features.
Ectopic cortisol-producing adrenocortical adenoma in the renal hilum: histopathological features and steroidogenic enzyme profile.
Immunohistochemical study of cytochrome b5 in human adrenal gland and in adrenocortical adenomas from patients with Cushing's syndrome.
Adrenal Hyperplasia, Congenital
A novel A10E homozygous mutation in the HSD3B2 gene causing severe salt-wasting 3beta-hydroxysteroid dehydrogenase deficiency in 46,XX and 46,XY French-Canadians: evaluation of gonadal function after puberty.
A novel homozygous nonsense mutations E135* in the type II 3beta-hydroxysteroid dehydrogenase gene in a girl with salt-losing congenital adrenal hyperplasia. Mutations in brief no. 168. Online.
A novel nonstop mutation in the stop codon and a novel missense mutation in the type II 3beta-hydroxysteroid dehydrogenase (3beta-HSD) gene causing, respectively, nonclassic and classic 3beta-HSD deficiency congenital adrenal hyperplasia.
An adrenal rest tumour in the perirenal region in a patient with congenital adrenal hyperplasia due to congenital 3beta-hydroxysteroid dehydrogenase deficiency.
Carboxyl-Terminal Mutations in 3{beta}-Hydroxysteroid Dehydrogenase Type II Cause Severe Salt-Wasting Congenital Adrenal Hyperplasia.
Carriers for type II 3beta-hydroxysteroid dehydrogenase (HSD3B2) deficiency can only be identified by HSD3B2 genotype study and not by hormone test.
Delayed diagnosis of congenital adrenal hyperplasia with salt wasting due to type II 3beta-hydroxysteroid dehydrogenase deficiency.
Sonography of congenital adrenal hyperplasia due to partial deficiency of 3beta-hydroxysteroid dehydrogenase: a case report.
The Molecular and Clinical Spectrum of 3beta-hydroxysteroid Dehydrogenase Deficiency Disorder.
[Congenital adrenal hyperplasia due to 3beta-hydroxysteroid dehydrogenase deficiency]
Adrenal Rest Tumor
An adrenal rest tumour in the perirenal region in a patient with congenital adrenal hyperplasia due to congenital 3beta-hydroxysteroid dehydrogenase deficiency.
Adrenocortical Carcinoma
Decrease in the expression of the 3beta-hydroxysteroid dehydrogenase gene in human adrenal tissue during prepuberty and early puberty: implications for the mechanism of adrenarche.
Adrenocortical Hyperfunction
Changes in ultrasonographic appearance of adrenal glands in dogs with pituitary-dependent hyperadrenocorticism treated with trilostane.
Results of clinical examinations, laboratory tests, and ultrasonography in dogs with pituitary-dependent hyperadrenocorticism treated with trilostane.
Study of the effects of once daily doses of trilostane on cortisol concentrations and responsiveness to adrenocorticotrophic hormone in hyperadrenocorticoid dogs.
Alopecia
Higher levels of steroidogenic acute regulatory protein and type I 3beta-hydroxysteroid dehydrogenase in the scalp of men with androgenetic alopecia.
Treatment of canine Alopecia X with trilostane.
Androgen-Insensitivity Syndrome
Evaluation of the tubular and interstitial functions of the testis in 46,XY patients with ambiguous genitalia.
Masculinizing genitoplasty in intersex patients.
Barrett Esophagus
Proteomic screening of a cell line model of esophageal carcinogenesis identifies cathepsin D and aldo-keto reductase 1C2 and 1B10 dysregulation in Barrett's esophagus and esophageal adenocarcinoma.
Breast Neoplasms
Analysis of 17beta-hydroxysteroid dehydrogenase types 5, 7, and 12 genetic sequence variants in breast cancer cases from French Canadian Families with high risk of breast and ovarian cancer.
Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma.
Genetic Variation in the Progesterone Receptor and Metabolism Pathways and Hormone Therapy in Relation to Breast Cancer Risk.
Identification of miR-193b targets in breast cancer cells and systems biological analysis of their functional impact.
Induction of 1C aldoketoreductases and other drug dose-dependent genes upon acquisition of anthracycline resistance.
Induction of 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase type 1 gene transcription in human breast cancer cell lines and in normal mammary epithelial cells by interleukin-4 and interleukin-13.
Inhibition of 17beta-hydroxysteroid dehydrogenase type 7 modulates breast cancer protein profile and enhances apoptosis by down-regulating GRP78.
Intratumoral estrogen disposition in breast cancer.
In vitro inhibition of AKR1Cs by sulphonylureas and the structural basis.
Non-competitive steroid inhibition of oestrogen receptor functions.
Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily.
Selective loss of AKR1C1 and AKR1C2 in breast cancer and their potential effect on progesterone signaling.
Stromal markers AKR1C1 and AKR1C2 are prognostic factors in primary human breast cancer.
Structural basis for the selective inhibition of human 3beta-hydroxysteroid dehydrogenase 1 in human breast tumor MCF-7 cells.
Structure/function of the inhibition of human 3beta-hydroxysteroid dehydrogenase type 1 and type 2 by trilostane.
The functions of key residues in the inhibitor, substrate and cofactor sites of human 3beta-hydroxysteroid dehydrogenase type 1 are validated by mutagenesis.
The higher affinity of human type 1 3beta-hydroxysteroid dehydrogenase (3beta-HSD1) for substrate and inhibitor steroids relative to human 3beta-HSD2 is validated in MCF-7 tumor cells and related to subunit interactions.
The role of cytochromes p450 and aldo-keto reductases in prognosis of breast carcinoma patients.
The Stimulation of HSD17B7 Expression by Estradiol Provides a Powerful Feed-Forward Mechanism for Estradiol Biosynthesis in Breast Cancer Cells.
Carcinogenesis
AKR1C2 small interfering RNA (siRNA) inhibited beta-catenin expression and transcriptional activation in human liver cancer cell line QGY7701.
Differential proteomic analysis of hepatocellular carcinoma.
Proteomic screening of a cell line model of esophageal carcinogenesis identifies cathepsin D and aldo-keto reductase 1C2 and 1B10 dysregulation in Barrett's esophagus and esophageal adenocarcinoma.
Small interfering RNA (siRNA) inhibited human liver cancer cell line SMMC7721 proliferation and tumorigenesis.
Up-Regulated AKR1C2 is correlated with favorable prognosis in thyroid carcinoma.
Carcinoma
Differential gene expression between squamous cell carcinoma of esophageus and its normal epithelium; altered pattern of mal, akr1c2, and rab11a expression.
Mefenamic acid enhances anticancer drug sensitivity via inhibition of aldo-keto reductase 1C enzyme activity.
Steroid-converting enzymes in human ovarian carcinomas.
Stromal markers AKR1C1 and AKR1C2 are prognostic factors in primary human breast cancer.
The roles of AKR1C1 and AKR1C2 in ethyl-3,4-dihydroxybenzoateinduced esophageal squamous cell carcinoma cell death.
Carcinoma, Ductal
The Stimulation of HSD17B7 Expression by Estradiol Provides a Powerful Feed-Forward Mechanism for Estradiol Biosynthesis in Breast Cancer Cells.
Carcinoma, Ovarian Epithelial
Steroid-converting enzymes in human ovarian carcinomas.
Carcinoma, Squamous Cell
Differential gene expression between squamous cell carcinoma of esophageus and its normal epithelium; altered pattern of mal, akr1c2, and rab11a expression.
Mefenamic acid enhances anticancer drug sensitivity via inhibition of aldo-keto reductase 1C enzyme activity.
Chondrodysplasia Punctata
Genetic disorders of cholesterol biosynthesis in mice and humans.
Choriocarcinoma
Oestrogen formation from C19 precursors in human choriocarcinoma in culture.
Cystitis, Interstitial
Differentiation associated changes in gene expression profiles of interstitial cystitis and control urothelial cells.
Diabetes Mellitus, Type 1
3beta-hydroxysteroid dehydrogenase autoantibodies are rare in premature ovarian failure.
Diabetes Mellitus, Type 2
[Ginkgo biloba extract enhances testosterone synthesis of Leydig cells in type 2 diabetic rats]
Disorder of Sex Development, 46,XY
Masculinizing genitoplasty in intersex patients.
The Molecular and Clinical Spectrum of 3beta-hydroxysteroid Dehydrogenase Deficiency Disorder.
Disorders of Sex Development
[Rare forms of female pseudohermaphroditism: when to investigate?]
Distemper
Distribution of 3beta-hydroxysteroid dehydrogenase in the cerebellum in canine distemper virus infection.
Endometrial Neoplasms
Expression of enzyme associated with steroid hormone synthesis and local production of steroid hormone in endometrial carcinoma cells.
Important roles of the AKR1C2 and SRD5A1 enzymes in progesterone metabolism in endometrial cancer model cell lines.
Endometriosis
Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis.
Expression of human aldo-keto reductase 1C2 in cell lines of peritoneal endometriosis: Potential implications in metabolism of progesterone and dydrogesterone and inhibition by progestins.
Ten estrogen-related polymorphisms and endometriosis: a study of multiple gene-gene interactions.
Esophageal Squamous Cell Carcinoma
The roles of AKR1C1 and AKR1C2 in ethyl-3,4-dihydroxybenzoateinduced esophageal squamous cell carcinoma cell death.
Glaucoma
HSD18B7 Enzyme Assay Technique Using a Triple Quadrupole Mass Spectrometer.
Gonadal Dysgenesis
Evaluation of the tubular and interstitial functions of the testis in 46,XY patients with ambiguous genitalia.
Gonadal Dysgenesis, Mixed
Masculinizing genitoplasty in intersex patients.
Herpes Zoster
A case of aldosterone-producing adenoma with severe postoperative hyperkalemia.
A case with primary aldosteronism due to unilateral multiple adrenocortical micronodules.
Androgen synthesis in adrenarche.
Changes in the glomerulosa cell phenotype during adrenal regeneration in rats.
Dehydroepiandrosterone and dehydroepiandrosterone sulfate production in the human adrenal during development and aging.
Insidious adrenocortical insufficiency underlies neuroendocrine dysregulation in TIF-2 deficient mice.
Morphometric and statistical analysis of macro- and microscopic characteristics of the brain and their relationships with adrenocortical histophysiology in newborn rats.
Properties of rat adrenal zona reticularis cells: preparation by gravitational sedimentation.
Unique cases of unilateral hyperaldosteronemia due to multiple adrenocortical micronodules, which can only be detected by selective adrenal venous sampling.
Hirsutism
3{alpha}-Hydroxysteroid Dehydrogenase Type III Deficiency: A Novel Mechanism for Hirsutism.
Genotyping of the type II 3beta-hydroxysteroid dehydrogenase gene (HSD3B2) in women with hirsutism and elevated ACTH-stimulated delta(5)-steroids.
Refining hormonal diagnosis of type II 3beta-hydroxysteroid dehydrogenase deficiency in patients with premature pubarche and hirsutism based on HSD3B2 genotyping.
Hyperaldosteronism
A case with primary aldosteronism due to unilateral multiple adrenocortical micronodules.
Hypospadias
Characterization of two novel homozygous missense mutations involving codon 6 and 259 of type II 3beta-hydroxysteroid dehydrogenase (3betaHSD) gene causing, respectively, nonsalt-wasting and salt-wasting 3betaHSD deficiency disorder.
Defects of the testosterone biosynthetic pathway in boys with hypospadias.
Fine mapping analysis confirms and strengthens linkage of four chromosomal regions in familial hypospadias.
Lack of defects in androgen production in children with hypospadias.
Infections
HIV-1 clade C infection and progressive disruption in the relationship between cortisol, DHEAS and CD4 cell numbers: a two-year follow-up study.
Liver receptor homolog-1 stimulates the progesterone biosynthetic pathway during follicle-stimulating hormone-induced granulosa cell differentiation.
Insulin Resistance
An analysis of the relationship between insulin resistance and the activity of steroid C17,20-lyase and 3beta-hydroxysteroid dehydrogenase in ovaries and adrenals in women with polycystic ovary syndrome.
Cinnamic acid based thiazolidinediones inhibit human P450c17 and 3beta-hydroxysteroid dehydrogenase and improve insulin sensitivity independent of PPARgamma agonist activity.
The hormonal phenotype of Nonclassic 3 beta-hydroxysteroid dehydrogenase (HSD3B) deficiency in hyperandrogenic females is associated with insulin-resistant polycystic ovary syndrome and is not a variant of inherited HSD3B2 deficiency.
Klinefelter Syndrome
Masculinizing genitoplasty in intersex patients.
Liver Neoplasms
AEG-1 Promotes Metastasis Through Downstream AKR1C2 and NF1 in Liver Cancer.
AKR1C2 small interfering RNA (siRNA) inhibited beta-catenin expression and transcriptional activation in human liver cancer cell line QGY7701.
Growth factor NUN increased AKR1C2 expression by activated CDK2 related RB signal transduction pathway in human liver cancer cell line.
High-Content Functional Screening of AEG-1 and AKR1C2 for the Promotion of Metastasis in Liver Cancer.
Small interfering RNA (siRNA) inhibited human liver cancer cell line SMMC7721 proliferation and tumorigenesis.
Lung Neoplasms
NNK reduction pathway gene polymorphisms and risk of lung cancer.
Metabolism, Inborn Errors
Genetic disorders of cholesterol biosynthesis in mice and humans.
Mevalonate Kinase Deficiency
Genetic disorders of cholesterol biosynthesis in mice and humans.
Molluscum Contagiosum
Similarity in genome organization between Molluscum contagiosum virus (MCV) and vaccinia virus (VV): identification of MCV homologues of the VV genes for protein kinase 2, structural protein VP8, RNA polymerase 35 kDa subunit and 3beta-hydroxysteroid dehydrogenase.
Neoplasm Metastasis
AEG-1 Promotes Metastasis Through Downstream AKR1C2 and NF1 in Liver Cancer.
High-Content Functional Screening of AEG-1 and AKR1C2 for the Promotion of Metastasis in Liver Cancer.
Neoplasms
A case of aldosterone-producing adenoma with severe postoperative hyperkalemia.
Adrenocortical carcinoma manifesting pure primary aldosteronism: a case report and analysis of steroidogenic enzymes.
An adrenal rest tumour in the perirenal region in a patient with congenital adrenal hyperplasia due to congenital 3beta-hydroxysteroid dehydrogenase deficiency.
Bilateral aldosteronoma associated with secondary aldosteronism in a chronic hemodialysis subject.
Comparison of crystal structures of human type 3 3alpha-hydroxysteroid dehydrogenase reveals an "induced-fit" mechanism and a conserved basic motif involved in the binding of androgen.
Differential gene expression between squamous cell carcinoma of esophageus and its normal epithelium; altered pattern of mal, akr1c2, and rab11a expression.
Enzyme histochemical and electron microscopic study of a virilizing adrenocortical adenoma.
Identification of key amino acids responsible for the substantially higher affinities of human type 1 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD1) for substrates, coenzymes, and inhibitors relative to human 3beta-HSD2.
Impaired dihydrotestosterone catabolism in human prostate cancer: critical role of AKR1C2 as a pre-receptor regulator of androgen receptor signaling.
Incidentally detected giant oncocytoma arising in retroperitoneal heterotopic adrenal tissue.
Intratumoral estrogen disposition in breast cancer.
Localization and altered expression of AKR1C family members in human ovarian tissues.
Long-term in vitro treatment of human glioblastoma cells with temozolomide increases resistance in vivo through up-regulation of GLUT transporter and aldo-keto reductase enzyme AKR1C expression.
Mefenamic acid enhances anticancer drug sensitivity via inhibition of aldo-keto reductase 1C enzyme activity.
Modulated expression of genes encoding estrogen metabolizing enzymes by G1-phase cyclin-dependent kinases 6 and 4 in human breast cancer cells.
Origin and evolution of somatic cell testicular tumours in transgenic mice.
Overexpression of aldo-keto reductase 1C2 as a high-risk factor in bladder cancer.
Preclinical Evaluation of the Supercritical Extract of Azadirachta Indica (Neem) Leaves In Vitro and In Vivo on Inhibition of Prostate Cancer Tumor Growth.
Quantitative analysis of the human AKR family members in cancer cell lines using the mTRAQ/MRM approach.
Selective loss of AKR1C1 and AKR1C2 in breast cancer and their potential effect on progesterone signaling.
Small interfering RNA (siRNA) inhibited human liver cancer cell line SMMC7721 proliferation and tumorigenesis.
Stromal markers AKR1C1 and AKR1C2 are prognostic factors in primary human breast cancer.
The higher affinity of human type 1 3beta-hydroxysteroid dehydrogenase (3beta-HSD1) for substrate and inhibitor steroids relative to human 3beta-HSD2 is validated in MCF-7 tumor cells and related to subunit interactions.
The role of cytochromes p450 and aldo-keto reductases in prognosis of breast carcinoma patients.
The Stimulation of HSD17B7 Expression by Estradiol Provides a Powerful Feed-Forward Mechanism for Estradiol Biosynthesis in Breast Cancer Cells.
Up-Regulated AKR1C2 is correlated with favorable prognosis in thyroid carcinoma.
Use of antibodies against LH receptor, 3beta-hydroxysteroid dehydrogenase and vimentin to characterize different types of testicular tumour in dogs.
Nevus
Mutations in the NSDHL gene, encoding a 3beta-hydroxysteroid dehydrogenase, cause CHILD syndrome.
Obesity, Abdominal
Intra-adipose sex steroid metabolism and body fat distribution in idiopathic human obesity.
Obstetric Labor, Premature
Identification of key amino acids responsible for the substantially higher affinities of human type 1 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD1) for substrates, coenzymes, and inhibitors relative to human 3beta-HSD2.
Polycystic Ovary Syndrome
An analysis of the relationship between insulin resistance and the activity of steroid C17,20-lyase and 3beta-hydroxysteroid dehydrogenase in ovaries and adrenals in women with polycystic ovary syndrome.
Concentration of unconjugated adrenogenic hormones and their precursors in normal and polycystic ovaries.
The hormonal phenotype of Nonclassic 3 beta-hydroxysteroid dehydrogenase (HSD3B) deficiency in hyperandrogenic females is associated with insulin-resistant polycystic ovary syndrome and is not a variant of inherited HSD3B2 deficiency.
Primary Ovarian Insufficiency
3beta-hydroxysteroid dehydrogenase autoantibodies are rare in premature ovarian failure.
Human leukocyte antigen-DQB1* genotypes encoding aspartate at position 57 are associated with 3beta-hydroxysteroid dehydrogenase autoimmunity in premature ovarian failure.
Steroid-cell autoantibodies are preferentially expressed in women with premature ovarian failure who have adrenal autoimmunity.
Prostatic Hyperplasia
Pre-receptor regulation of the androgen receptor.
Prostatic Neoplasms
3beta-hydroxysteroid dehydrogenase is a possible pharmacological target in the treatment of castration-resistant prostate cancer.
AKR1C2 and AKR1C3 mediated prostaglandin D2 metabolism augments the PI3K/Akt proliferative signaling pathway in human prostate cancer cells.
Androgen-independent prostate cancer cells acquire the complete steroidogenic potential of synthesizing testosterone from cholesterol.
Human type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells.
Impaired dihydrotestosterone catabolism in human prostate cancer: critical role of AKR1C2 as a pre-receptor regulator of androgen receptor signaling.
In vitro inhibition of AKR1Cs by sulphonylureas and the structural basis.
Modulation of AKR1C2 by curcumin decreases testosterone production in prostate cancer.
Overexpression of aldo-keto reductase 1C2 is associated with disease progression in patients with prostatic cancer.
Role of human type 3 3alpha-hydroxysteroid dehydrogenase (AKR1C2) in androgen metabolism of prostate cancer cells.
Selective reduction of AKR1C2 in prostate cancer and its role in DHT metabolism.
Prostatic Neoplasms, Castration-Resistant
Overexpression of aldo-keto reductase 1C2 is associated with disease progression in patients with prostatic cancer.
Pseudohypoaldosteronism
Epidemiologic study of adrenal gland disorders in Japan.
steroid 11beta-monooxygenase deficiency
Congenital adrenal hyperplasia and P450 oxidoreductase deficiency.
steroid 17alpha-monooxygenase deficiency
Defects of the testosterone biosynthetic pathway in boys with hypospadias.
steroid 21-monooxygenase deficiency
Definitive diagnosis of enzymatic deficiencies of steroidogenesis in at-risk newborns and infants by urinary marker analysis using GC/MS-SIM.
steroid delta-isomerase deficiency
A novel nonstop mutation in the stop codon and a novel missense mutation in the type II 3beta-hydroxysteroid dehydrogenase (3beta-HSD) gene causing, respectively, nonclassic and classic 3beta-HSD deficiency congenital adrenal hyperplasia.
Testicular Neoplasms
Immunohistochemical detection of inhibin-alpha, -betaB, and -betaA chains and 3beta-hydroxysteroid dehydrogenase in canine testicular tumors and normal testes.
Thyroid Cancer, Papillary
Up-Regulated AKR1C2 is correlated with favorable prognosis in thyroid carcinoma.
Thyroid Neoplasms
Up-Regulated AKR1C2 is correlated with favorable prognosis in thyroid carcinoma.
Tuberculosis
Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase.
Urinary Bladder Neoplasms
Cisplatin resistance by induction of aldo-keto reductase family 1 member C2 in human bladder cancer cells.
Overexpression of aldo-keto reductase 1C2 as a high-risk factor in bladder cancer.
Uterine Diseases
Enzymes of the AKR1B and AKR1C Subfamilies and Uterine Diseases.
Expression of human aldo-keto reductase 1C2 in cell lines of peritoneal endometriosis: Potential implications in metabolism of progesterone and dydrogesterone and inhibition by progestins.
In vitro inhibition of AKR1Cs by sulphonylureas and the structural basis.
Vaccinia
Similarity in genome organization between Molluscum contagiosum virus (MCV) and vaccinia virus (VV): identification of MCV homologues of the VV genes for protein kinase 2, structural protein VP8, RNA polymerase 35 kDa subunit and 3beta-hydroxysteroid dehydrogenase.
Virus Diseases
Distribution of 3beta-hydroxysteroid dehydrogenase in the cerebellum in canine distemper virus infection.
Vitamin A Deficiency
Effect of vitamin A deficiency on 3beta-hydroxysteroid dehydrogenase activity and corticosterone in the rat adrenal.
Xanthomatosis
A novel somatic mutation of the 3beta-hydroxysteroid dehydrogenase gene in sporadic cutaneous verruciform xanthoma.