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shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+
shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+

-
-
-
-
shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+
active site structure, reaction and kinetic mechanisms
-
shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+
conserved residues Asp103 and Lys67 are important for catalysis in all three paralogues, kinetic mechanism of paralogue HI0607 and substrate binding site
-
shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+
active-site base is K92. After the binding of quinate and NAD+, the oxygen of the C3-OH of quinate forms a hydrogen bond to the side chain of the conserved T88 and K92 functions as the active-site base to remove the proton on the C3-OH. Simultaneously,a hydride is transferred from C3 of quinate to NAD+
shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+
steady-state ordered bi-bi kinetic mechanism. The hydride transferred from NADPH and protons transferred from the solvent in the catalytic cycle are not significantly rate limiting in the overall reaction. Both hydride and proton transfers are concerted, and acid/base chemistry takes place in catalysis and substrate binding
shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+
the active enzyme for dehydrogenation of shikimate contains a deprotonated K70 residue, a deprotonated D106, and a protonated Y216. The hydride transfer and the deprotonation of the 3-hydroxyl group of shikimate proceed in a concerted manner. K70 functions as a general base and becomes protonated in the dehydrogenation reaction. The proton is then transferred to the bulk solvent via the short proton-conducting wire. D106 plays a critical role in the transfer of the proton to the bulk solvent
shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+
the pro-R hydrogen of the nicotinamide C4 is 3.35 A from the C3 of shikimate. The catalytic K385 and D423 residues are proximal to the C3-hydroxyl of shikimate, which is deprotonated in the oxidation reaction. The enzyme adopts a concave architecture that places the active sites in a face-to-face arrangement
-
shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+
catalytic mechanism, residue Lys69 plays a catalytic role and is not involved in substrate binding, overview
shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+
the enzyme catalysis follows a sequential random mechanism, enzyme catalysis depends on acid-basic amino acids
-
shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+
steady-state ordered bi-bi kinetic mechanism. The hydride transferred from NADPH and protons transferred from the solvent in the catalytic cycle are not significantly rate limiting in the overall reaction. Both hydride and proton transfers are concerted, and acid/base chemistry takes place in catalysis and substrate binding
-
shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+
the enzyme catalysis follows a sequential random mechanism, enzyme catalysis depends on acid-basic amino acids
-
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3-dehydroquinate
3-dehydroshikimate + H2O
3-dehydroquinate + NADH + H+
quinate + NAD+
3-dehydroquinate + NADPH + H+
quinate + NADP+
3-dehydroshikimate + NAD(P)H + H+
shikimate + NAD(P)+
3-dehydroshikimate + NADH
shikimate + NAD+
-
SDH reaction, very low activity with NAD+
-
r
3-dehydroshikimate + NADH + H+
shikimate + NAD+
3-dehydroshikimate + NADPH
?
3-dehydroshikimate + NADPH
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
shikimate + NADP+
L-quinate + NADP+
3-dehydroquinate + NADPH + H+
-
-
r
quinate + NAD(P)+
3-dehydroquinate + NAD(P)H + H+
-
-
?
quinate + NAD+
3-dehydroquinate + NADH + H+
quinate + NADP+
3-dehydroquinate + NADPH + H+
shikimate + NAD(P)+
3-dehydroshikimate + NAD(P)H + H+
shikimate + NAD+
3-dehydroshikimate + NADH + H+
shikimate + NADP+
3-dehydroshikimate + NADPH
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
additional information
?
-
3-dehydroquinate

3-dehydroshikimate + H2O
-
-
-
r
3-dehydroquinate
3-dehydroshikimate + H2O
-
DQD reaction
-
r
3-dehydroquinate
3-dehydroshikimate + H2O
-
-
-
r
3-dehydroquinate + NADH + H+

quinate + NAD+
-
-
r
3-dehydroquinate + NADH + H+
quinate + NAD+
-
-
r
3-dehydroquinate + NADPH + H+

quinate + NADP+
-
-
r
3-dehydroquinate + NADPH + H+
quinate + NADP+
-
-
r
3-dehydroshikimate + NAD(P)H + H+

shikimate + NAD(P)+
-
-
r
3-dehydroshikimate + NAD(P)H + H+
shikimate + NAD(P)+
fourth enzyme involved in the shikimate pathway
-
r
3-dehydroshikimate + NAD(P)H + H+
shikimate + NAD(P)+
-
-
r
3-dehydroshikimate + NAD(P)H + H+
shikimate + NAD(P)+
fourth enzyme involved in the shikimate pathway
-
r
3-dehydroshikimate + NADH + H+

shikimate + NAD+
less than 1% of the rate with 3-dehydroquinate
-
r
3-dehydroshikimate + NADH + H+
shikimate + NAD+
less than 1% of the rate with 3-dehydroquinate
-
r
3-dehydroshikimate + NADPH

?
-
enzyme of shikimic acid biosynthesis
-
r
3-dehydroshikimate + NADPH
?
-
pathway of biosynthesis of aromatic amino acids
-
r
3-dehydroshikimate + NADPH

shikimate + NADP+
-
-
-
r
3-dehydroshikimate + NADPH
shikimate + NADP+
-
-
r
3-dehydroshikimate + NADPH
shikimate + NADP+
-
-
-
r
3-dehydroshikimate + NADPH
shikimate + NADP+
-
NADH may substitute for NADPH
-
r
3-dehydroshikimate + NADPH
shikimate + NADP+
-
-
-
r
3-dehydroshikimate + NADPH
shikimate + NADP+
-
-
?
3-dehydroshikimate + NADPH
shikimate + NADP+
-
-
?
3-dehydroshikimate + NADPH
shikimate + NADP+
-
-
?
3-dehydroshikimate + NADPH
shikimate + NADP+
-
-
-
r
3-dehydroshikimate + NADPH
shikimate + NADP+
-
SDH reaction
-
r
3-dehydroshikimate + NADPH + H+

shikimate + NADP+
-
structure of the enzyme is a compact alpha/beta sandwich with two distinct domains, responsible for binding substrate and NADP cofactor, respectively
-
?
3-dehydroshikimate + NADPH + H+
shikimate + NADP+
-
-
r
3-dehydroshikimate + NADPH + H+
shikimate + NADP+
-
-
r
3-dehydroshikimate + NADPH + H+
shikimate + NADP+
-
-
-
?
3-dehydroshikimate + NADPH + H+
shikimate + NADP+
-
-
r
3-dehydroshikimate + NADPH + H+
shikimate + NADP+
catalytic mechanism, residue Lys69 plays a catalytic role and is not involved in substrate binding
-
r
quinate + NAD+

3-dehydroquinate + NADH + H+
-
-
r
quinate + NAD+
3-dehydroquinate + NADH + H+
in contrast to shikimate, quinate may form a hydrogen bond to the NAD+, and the hydroxyl group of a active-site threonine hydrogen bonds to quinate more effectively than shikimate resulting in a lower Michaelis constant and higher catalytic efficiency for quinate
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?
quinate + NAD+
3-dehydroquinate + NADH + H+
-
-
r
quinate + NAD+
3-dehydroquinate + NADH + H+
the fourth enzyme in the shikimate pathway
-
r
quinate + NAD+
3-dehydroquinate + NADH + H+
the fourth enzyme in the shikimate pathway
-
r
quinate + NADP+

3-dehydroquinate + NADPH + H+
-
reversible activity of YdiB, no activity with paralogue HI0607
-
r
quinate + NADP+
3-dehydroquinate + NADPH + H+
-
-
r
quinate + NADP+
3-dehydroquinate + NADPH + H+
-
-
r
shikimate + NAD(P)+

3-dehydroshikimate + NAD(P)H + H+
-
-
?
shikimate + NAD(P)+
3-dehydroshikimate + NAD(P)H + H+
-
-
?
shikimate + NAD+

3-dehydroshikimate + NADH + H+
-
-
-
r
shikimate + NAD+
3-dehydroshikimate + NADH + H+
-
-
?
shikimate + NAD+
3-dehydroshikimate + NADH + H+
-
-
r
shikimate + NAD+
3-dehydroshikimate + NADH + H+
-
-
r
shikimate + NAD+
3-dehydroshikimate + NADH + H+
-
-
r
shikimate + NAD+
3-dehydroshikimate + NADH + H+
-
-
r
shikimate + NAD+
3-dehydroshikimate + NADH + H+
-
-
r
shikimate + NAD+
3-dehydroshikimate + NADH + H+
-
-
r
shikimate + NAD+
3-dehydroshikimate + NADH + H+
-
-
r
shikimate + NADP+

3-dehydroshikimate + NADPH
-
assay at 24°C, pH 9.0
-
?
shikimate + NADP+
3-dehydroshikimate + NADPH
-
SDH reaction
-
r
shikimate + NADP+

3-dehydroshikimate + NADPH + H+
-
-
?
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
?
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
Bambusa sp.
-
-
-
?
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
?
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
?
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
?
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
?
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
?
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
analysis of the 3-dehydroshikimate binding site
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
reversible activity of YdiB and AroE, paralogue HI0607 catalyzes the oxidative reaction with low activity
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
A0A1K3RIC7
-
-
?
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
A0A1K3RIC7
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
?
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
A0A1K3RIC7
-
-
?
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
?
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
?
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
?
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
?
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
the fourth enzyme in the shikimate pathway
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
the fourth enzyme in the shikimate pathway
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
?
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
?
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
?
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
?
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
?
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
r
additional information

?
-
-
the bifunctional enzyme performs dehydroquinate dehydratase and shikimate dehydrogenase activities, metabolic channeling
-
?
additional information
?
-
-
the bifunctional enzyme performs dehydroquinate dehydratase and shikimate dehydrogenase activities
-
?
additional information
?
-
The bifunctional enzyme also catalyzes dehydration of 3-dehydroquinate to 3-dehydroshikimate
-
?
additional information
?
-
The bifunctional enzyme also catalyzes dehydration of 3-dehydroquinate to 3-dehydroshikimate
-
?
additional information
?
-
-
The bifunctional enzyme also catalyzes dehydration of 3-dehydroquinate to 3-dehydroshikimate
-
?
additional information
?
-
no activity with quinate
-
?
additional information
?
-
no activity with quinate
-
?
additional information
?
-
usage of recombinant shikimate dehydrogenase as sensor reaction for determination of the cytosolic NADPH/NADP ratio in Saccharomyces cerevisiae, quantitative measurements of physiological variables in the cytosolic compartment by GC-MS/MS, cytosolic NADPH/NADP ratio in batch experiments, method, overview
-
?
additional information
?
-
-
no activity with quinate
-
?
additional information
?
-
-
fourth enzyme in the shikimate biosynthetic pathway
-
?
additional information
?
-
-
the cytosolic shikimate synthesis cannot complement loss of the plastidial pathway
-
?
additional information
?
-
the cytosolic shikimate synthesis cannot complement loss of the plastidial pathway
-
?
additional information
?
-
the cytosolic shikimate synthesis cannot complement loss of the plastidial pathway
-
?
additional information
?
-
-
the enzyme also shows 3-dehydroquinate dehydratase activity, EC 4.2.1.10
-
?
additional information
?
-
the enzyme also shows 3-dehydroquinate dehydratase activity, EC 4.2.1.10
-
?
additional information
?
-
the enzyme also shows 3-dehydroquinate dehydratase activity, EC 4.2.1.10
-
?
additional information
?
-
-
the bifunctional enzyme dehydroquinate dehydratase/shikimate dehydrogenase (DQD/SDH cf. EC 4.2.1.10 and EC 1.1.1.25) catalyzes the the conversion of 3-dehydroquinate to shikimate via 3-dehydroshikimate
-
?
additional information
?
-
-
the bifunctional enzyme dehydroquinate dehydratase/shikimate dehydrogenase (DQD3/SDH cf. EC 4.2.1.10 and EC 1.1.1.25) catalyzes the the conversion of 3-dehydroquinate to shikimate via 3-dehydroshikimate
-
?
additional information
?
-
-
The bifunctional enzyme also catalyzes dehydration of 3-dehydroquinate to 3-dehydroshikimate
-
?
additional information
?
-
-
The bifunctional enzyme also catalyzes dehydration of 3-dehydroquinate to 3-dehydroshikimate. Under saturating conditions, Poptr5 displays strong activity with shikimate but no detectable activity with quinate even at elevated enzyme concentrations. The isozyme shows no quinate hydrolyase activity
-
?
additional information
?
-
-
under saturating conditions, Poptr1 displays strong activity with shikimate but no detectable activity with quinate even at elevated enzyme concentrations. The isozyme shows no quinate hydrolyase activity
-
?
additional information
?
-
-
the bifunctional enzyme dehydroquinate dehydratase/shikimate dehydrogenase (DQD/SDH cf. EC 4.2.1.10 and EC 1.1.1.25) catalyzes the the conversion of 3-dehydroquinate to shikimate via 3-dehydroshikimate
-
?
additional information
?
-
-
the bifunctional enzyme dehydroquinate dehydratase/shikimate dehydrogenase (DQD3/SDH cf. EC 4.2.1.10 and EC 1.1.1.25) catalyzes the the conversion of 3-dehydroquinate to shikimate via 3-dehydroshikimate
-
?
additional information
?
-
-
The bifunctional enzyme also catalyzes dehydration of 3-dehydroquinate to 3-dehydroshikimate. Under saturating conditions, Poptr5 displays strong activity with shikimate but no detectable activity with quinate even at elevated enzyme concentrations. The isozyme shows no quinate hydrolyase activity
-
?
additional information
?
-
-
under saturating conditions, Poptr1 displays strong activity with shikimate but no detectable activity with quinate even at elevated enzyme concentrations. The isozyme shows no quinate hydrolyase activity
-
?
additional information
?
-
no activity with quinate
-
?
additional information
?
-
no activity with quinate
-
?
additional information
?
-
broad extent to which the SDH enzyme superfamily has diversified. 5 evolutionarily distinct SDH homologs in the genome of the common soil-inhabiting bacterium, Pseudomonas putida KT2440
-
?
additional information
?
-
broad extent to which the SDH enzyme superfamily has diversified. 5 evolutionarily distinct SDH homologs in the genome of the common soil-inhabiting bacterium, Pseudomonas putida KT2440
-
?
additional information
?
-
no activity with quinate
-
?
additional information
?
-
no activity with quinate
-
?
additional information
?
-
even in the presence of a high concentration of quinate (4 mM), SDH displays no activity using either NADP+ or NAD+ as a cofactor
-
?
additional information
?
-
the SDH domain from the Toxoplasma gondii is part of the AROM complex. No activity with quinate
-
?
additional information
?
-
isozyme VvSDH1 also produces gallate from shikimate with NADP+
-
?
additional information
?
-
isozyme VvSDH1 also produces gallate from shikimate with NADP+
-
?
additional information
?
-
isozyme VvSDH1 also produces gallate from shikimate with NADP+
-
?
additional information
?
-
isozyme VvSDH1 also produces gallate from shikimate with NADP+
-
?
additional information
?
-
isozyme VvSDH2 does not produce gallate from shikimate
-
?
additional information
?
-
isozyme VvSDH2 does not produce gallate from shikimate
-
?
additional information
?
-
isozyme VvSDH2 does not produce gallate from shikimate
-
?
additional information
?
-
isozyme VvSDH2 does not produce gallate from shikimate
-
?
additional information
?
-
isozyme VvSDH3 also produces gallate from shikimate with NADP+ with low activity
-
?
additional information
?
-
isozyme VvSDH3 also produces gallate from shikimate with NADP+ with low activity
-
?
additional information
?
-
isozyme VvSDH3 also produces gallate from shikimate with NADP+ with low activity
-
?
additional information
?
-
isozyme VvSDH3 also produces gallate from shikimate with NADP+ with low activity
-
?
additional information
?
-
isozyme VvSDH4 also produces gallate from shikimate with NADP+ with low activity
-
?
additional information
?
-
isozyme VvSDH4 also produces gallate from shikimate with NADP+ with low activity
-
?
additional information
?
-
isozyme VvSDH4 also produces gallate from shikimate with NADP+ with low activity
-
?
additional information
?
-
isozyme VvSDH4 also produces gallate from shikimate with NADP+ with low activity
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
3-dehydroquinate
3-dehydroshikimate + H2O
3-dehydroshikimate + NAD(P)H + H+
shikimate + NAD(P)+
3-dehydroshikimate + NADPH
?
3-dehydroshikimate + NADPH
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
shikimate + NADP+
-
-
-
r
L-quinate + NADP+
3-dehydroquinate + NADPH + H+
-
-
-
r
quinate + NAD+
3-dehydroquinate + NADH + H+
quinate + NADP+
3-dehydroquinate + NADPH + H+
-
reversible activity of YdiB, no activity with paralogue HI0607
-
-
r
shikimate + NAD+
3-dehydroshikimate + NADH + H+
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
additional information
?
-
3-dehydroquinate

3-dehydroshikimate + H2O
-
-
-
-
r
3-dehydroquinate
3-dehydroshikimate + H2O
-
-
-
-
r
3-dehydroshikimate + NAD(P)H + H+

shikimate + NAD(P)+
fourth enzyme involved in the shikimate pathway
-
-
r
3-dehydroshikimate + NAD(P)H + H+
shikimate + NAD(P)+
fourth enzyme involved in the shikimate pathway
-
-
r
3-dehydroshikimate + NADPH

?
-
enzyme of shikimic acid biosynthesis
-
-
r
3-dehydroshikimate + NADPH
?
-
pathway of biosynthesis of aromatic amino acids
-
-
r
3-dehydroshikimate + NADPH

shikimate + NADP+
-
-
-
-
r
3-dehydroshikimate + NADPH
shikimate + NADP+
-
-
-
r
3-dehydroshikimate + NADPH
shikimate + NADP+
-
-
-
-
r
3-dehydroshikimate + NADPH
shikimate + NADP+
-
-
-
-
r
3-dehydroshikimate + NADPH
shikimate + NADP+
-
-
-
-
r
quinate + NAD+

3-dehydroquinate + NADH + H+
the fourth enzyme in the shikimate pathway
-
-
r
quinate + NAD+
3-dehydroquinate + NADH + H+
the fourth enzyme in the shikimate pathway
-
-
r
shikimate + NAD+

3-dehydroshikimate + NADH + H+
-
-
-
r
shikimate + NAD+
3-dehydroshikimate + NADH + H+
-
-
-
r
shikimate + NAD+
3-dehydroshikimate + NADH + H+
-
-
-
r
shikimate + NADP+

3-dehydroshikimate + NADPH + H+
-
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
Bambusa sp.
-
-
-
-
?
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
-
?
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
-
?
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
-
?
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
-
?
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
-
?
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
reversible activity of YdiB and AroE, paralogue HI0607 catalyzes the oxidative reaction with low activity
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
A0A1K3RIC7
-
-
-
?
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
A0A1K3RIC7
-
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
A0A1K3RIC7
-
-
-
?
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
-
?
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
-
?
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
the fourth enzyme in the shikimate pathway
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
the fourth enzyme in the shikimate pathway
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
-
?
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
-
?
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
-
?
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
-
?
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
-
?
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
-
-
-
r
additional information

?
-
-
the bifunctional enzyme performs dehydroquinate dehydratase and shikimate dehydrogenase activities, metabolic channeling
-
-
?
additional information
?
-
-
fourth enzyme in the shikimate biosynthetic pathway
-
-
?
additional information
?
-
-
the cytosolic shikimate synthesis cannot complement loss of the plastidial pathway
-
-
?
additional information
?
-
the cytosolic shikimate synthesis cannot complement loss of the plastidial pathway
-
-
?
additional information
?
-
the cytosolic shikimate synthesis cannot complement loss of the plastidial pathway
-
-
?
additional information
?
-
-
the bifunctional enzyme dehydroquinate dehydratase/shikimate dehydrogenase (DQD/SDH cf. EC 4.2.1.10 and EC 1.1.1.25) catalyzes the the conversion of 3-dehydroquinate to shikimate via 3-dehydroshikimate
-
-
?
additional information
?
-
-
the bifunctional enzyme dehydroquinate dehydratase/shikimate dehydrogenase (DQD3/SDH cf. EC 4.2.1.10 and EC 1.1.1.25) catalyzes the the conversion of 3-dehydroquinate to shikimate via 3-dehydroshikimate
-
-
?
additional information
?
-
-
the bifunctional enzyme dehydroquinate dehydratase/shikimate dehydrogenase (DQD/SDH cf. EC 4.2.1.10 and EC 1.1.1.25) catalyzes the the conversion of 3-dehydroquinate to shikimate via 3-dehydroshikimate
-
-
?
additional information
?
-
-
the bifunctional enzyme dehydroquinate dehydratase/shikimate dehydrogenase (DQD3/SDH cf. EC 4.2.1.10 and EC 1.1.1.25) catalyzes the the conversion of 3-dehydroquinate to shikimate via 3-dehydroshikimate
-
-
?
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1,2,4-triazolo[3,4-b][1,3,4]thiadiazole
A0A1K3RIC7
half-maximal inhibition at 0.023 mg/ml
2,2'-bithiophene-5-carboxylic acid
-
the inhibitor is identified by virtual screeening, 87% inhibition at 0.2 mM, competitive versus shikimate, uncompetitive versus NADP+. Flexible docking studies reveal that the inhibitor molecule makes interactions with catalytic residues
2,2-bisepigallocatechin gallate
about 50% inhibition at 0.0025 mM
2,4-Dichlorophenoxyacetic acid
-
-
2-([2-([2-([2-(2,3-dimethylanilino)-2-oxoethyl]sulfanyl)-1,3-benzothiazol-6-yl]amino)2-oxoethyl]sulfanyl)-N-(2-naphthyl)acetamide
IC50: 0.0029 mM, competitive inhibition with respect to shikimate, noncompetitive to NADP+, potent antibacterial activity
2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-4-carboxylic acid
2-[methyl[3-(trifluoromethyl)naphthalen-1-yl]amino]ethan-1-ol
3,5-Dihydroxybenzoate
-
moderate
3-(2-naphthyloxy)-4-oxo-2-(trifluoromethyl)-4H-chromen-7-yl 3-chlorobenzoate
IC50: 0.0039 mM, noncompetitive inhibition with respect to shikimate, competitive to NADP+
3-(3-fluoropyridin-4-yl)-6-(phenoxymethyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole
A0A1K3RIC7
-
3-(4-bromophenyl)-6-((2,4-dichlorophenoxy)methyl)-[1,2,4]-triazolo[3,4-b][1,3,4]thiadiazole
A0A1K3RIC7
half-maximal inhibition at 0.0396 mg/ml
3-(4-bromophenyl)-6-((2-methyl-4-chlorophenoxy)methyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
A0A1K3RIC7
half-maximal inhibition at 0.0216 mg/ml
3-(4-bromophenyl)-6-((4-chlorophenoxy)methyl)-[1,2,4]triazolo-[3,4-b][1,3,4]thiadiazole
A0A1K3RIC7
half-maximal inhibition at 0.0363 mg/ml
3-(4-bromophenyl)-6-((4-fluorophenoxy)methyl)-[1,2,4]triazolo-[3,4-b][1,3,4]thiadiazole
A0A1K3RIC7
half-maximal inhibition at 0.0795 mg/ml
3-(4-bromophenyl)-6-((4-methoxyphenoxy)methyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
A0A1K3RIC7
half-maximal inhibition at 0.0120 mg/ml
3-(4-bromophenyl)-6-((4-nitrophenoxy)methyl)-[1,2,4]triazolo-[3,4-b][1,3,4]thiadiazole
A0A1K3RIC7
half-maximal inhibition at 0.0586 mg/ml
3-(4-chlorophenyl)-6-((2-naphthyloxy)methyl)-[1,2,4]triazolo-[3,4-b][1,3,4]thiadiazole
A0A1K3RIC7
half-maximal inhibition at 0.168 mg/ml
3-(4-chlorophenyl)-6-((4-fluorophenoxy)methyl)-[1,2,4]triazolo-[3,4-b][1,3,4]thiadiazole
A0A1K3RIC7
half-maximal inhibition at 5.052 mg/ml
3-(4-chlorophenyl)-6-((4-nitrophenoxy)methyl)-[1,2,4]triazolo-[3,4-b][1,3,4]thiadiazole
A0A1K3RIC7
half-maximal inhibition at 0.00937 mg/ml
3-(4-fluorophenyl)-6-((2-naphthyloxy)methyl)-[1,2,4]triazolo-[3,4-b][1,3,4]thiadiazole
A0A1K3RIC7
-
3-(4-fluorophenyl)-6-((4-methoxyphenoxy)methyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
A0A1K3RIC7
half-maximal inhibition at 0.0663 mg/ml
3-(beta-naphthylmethyl)-6-((4-nitrophenoxy)methyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
A0A1K3RIC7
half-maximal inhibition at 0.0407 mg/ml
3-ethyl-3,4-dihydro-2H-1-benzopyran
4-[(morpholin-4-yl)methyl]benzoic acid
5-(hex-1-yn-1-yl)furan-2-carboxylic acid
6-((2,4-dichlorophenoxy)methyl)-3-(3-fluoropyridin-4-yl)-[1,2,4]-triazolo[3,4-b][1,3,4]thiadiazole
A0A1K3RIC7
-
6-((4-bromophenoxy)methyl)-3-(4-bromophenyl)-[1,2,4]triazolo-[3,4-b][1,3,4]thiadiazole
A0A1K3RIC7
half-maximal inhibition at 0.0144 mg/ml
6-((4-bromophenoxy)methyl)-3-(4-chlorophenyl)-[1,2,4]triazolo-[3,4-b][1,3,4]thiadiazole
A0A1K3RIC7
half-maximal inhibition at 0.00682 mg/ml
6-((4-fluorophenoxy)methyl)-3-(beta-naphthylmethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
A0A1K3RIC7
half-maximal inhibition at 0.0277 mg/ml
6-hydroxy-2,3-dihydrobenzo[b]furan-3-one
-
the inhibitor is identified by virtual screeening, 99% inhibition at 0.2 mM, mixed-type inhibition versus shikimate, uncompetitive versus NADP+. Flexible docking studies reveal that the inhibitor molecule makes interactions with catalytic residues
7-hydroxy-2,2,8-trimethyl-2,3-dihydro-4H-chromen-4-one
-
the inhibitor is identified by virtual screeening, 87% inhibition at 0.2 mM, competitive versus shikimate, uncompetitive versus NADP+. Flexible docking studies reveal that the inhibitor molecule makes interactions with catalytic residues
aurintricarboxylic acid
lower inhibitry potency, about 25% inhibition at 0.0025 mM
baicalein
about 25% inhibition at 0.0025 mM
butyl 2-([3-(2-naphthyloxy)4-oxo-2-(trifluoromethyl)4H-chromen-7-yl]oxy)propanoate
IC50: 0.0134 mM, noncompetitive inhibition with respect to shikimate, competitive to NADP+, potent antibacterial activity
cardiolipin
lower inhibitry potency, about 25% inhibition at 0.0025 mM
dianthrol
about 50% inhibition at 0.0025 mM
-
diethylenetriamine pentaacetic acid
lower inhibitry potency, about 25% inhibition at 0.0025 mM
ebselen
lower inhibitry potency, about 25% inhibition at 0.0025 mM
ellagic acid
about 50% inhibition at 0.0025 mM
epigallocatechin-3,5-digallate
about 50% inhibition at 0.0025 mM
epitheaflavin monogallate
about 50% inhibition at 0.0025 mM
HgCl2
-
complete inhibition at concentration 0.05 mM
hydroquinone
lower inhibitry potency, about 25% inhibition at 0.0025 mM
maesaquinone diacetate
IC50: 0.0035 mM, noncompetitive inhibition with respect to shikimate and NADP+
merbromin
lower inhibitry potency, about 25% inhibition at 0.0025 mM
methyl 3-hydroxy-1-benzothiophene-2-carboxylate
NADP+
product inhibition, competitive versus NADPH, noncompetitive versus 3-dehydroshikimate
nordihydroguaiaretic acid
lower inhibitry potency, about 25% inhibition at 0.0025 mM
p-hydroxymercuribenzoate
-
moderate
purpurogallin
about 50% inhibition at 0.0025 mM
pyridoxine
lower inhibitry potency, about 25% inhibition at 0.0025 mM
pyrogallin
about 50% inhibition at 0.0025 mM
quercetin
about 25% inhibition at 0.0025 mM
SDS
-
nearly complete inactivation of AroE at 0.02%
taxifolin
about 25% inhibition at 0.0025 mM
theaflavanin
about 25% inhibition at 0.0025 mM
theaflavin monogallate
about 50% inhibition at 0.0025 mM
theaflavin-3,3-digallate
about 25% inhibition at 0.0025 mM
[2-[2-(dimethylamino)ethoxy]phenyl]methanol
2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-4-carboxylic acid

A0A1K3RIC7
31% inhibition at 0.2 mM
2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-4-carboxylic acid
-
31% inhibition at 0.2 mM
2-[methyl[3-(trifluoromethyl)naphthalen-1-yl]amino]ethan-1-ol

A0A1K3RIC7
49% inhibition at 0.2 mM
2-[methyl[3-(trifluoromethyl)naphthalen-1-yl]amino]ethan-1-ol
-
49% inhibition at 0.2 mM
3-ethyl-3,4-dihydro-2H-1-benzopyran

A0A1K3RIC7
31% inhibition at 0.2 mM
3-ethyl-3,4-dihydro-2H-1-benzopyran
-
31% inhibition at 0.2 mM
4-[(morpholin-4-yl)methyl]benzoic acid

A0A1K3RIC7
31% inhibition at 0.2 mM
4-[(morpholin-4-yl)methyl]benzoic acid
-
31% inhibition at 0.2 mM
5-(hex-1-yn-1-yl)furan-2-carboxylic acid

A0A1K3RIC7
29% inhibition at 0.2 mM
5-(hex-1-yn-1-yl)furan-2-carboxylic acid
-
29% inhibition at 0.2 mM
Cu2+

-
-
curcumin

IC50: 0.0154 mM, noncompetitive inhibition with respect to shikimate and NADP+
curcumin
-
a noncompetitive inhibitor
epicatechin gallate

inhibits the AroE domain of the bifunctional dehydroquinate dehydratase-shikimate dehydrogenase (DHQ-SDH) from Arabidopsis thaliana
epicatechin gallate
over 75% inhibition at 0.0025 mM
epigallocatechin gallate

inhibits the AroE domain of the bifunctional dehydroquinate dehydratase-shikimate dehydrogenase (DHQ-SDH) from Arabidopsis thaliana
epigallocatechin gallate
over 75% inhibition at 0.0025 mM
epigallocatechin gallate
-
-
Hg2+

-
-
iodoacetate

-
-
methyl 3-hydroxy-1-benzothiophene-2-carboxylate

A0A1K3RIC7
33% inhibition at 0.2 mM
methyl 3-hydroxy-1-benzothiophene-2-carboxylate
-
33% inhibition at 0.2 mM
p-chloromercuribenzoate

-
-
p-chloromercuribenzoate
-
biphasic inhibition: first rapid inhibition leading to loss of 70% activity, then within 5 min loss of the remaining 30% activity, inhibition can be partially hindered by thiols and chloride
p-chloromercuribenzoate
-
-
p-chloromercuribenzoate
-
-
p-chloromercuribenzoate
-
-
p-chloromercuribenzoate
-
-
protocatechuic acid

-
competitive inhibition
protocatechuic acid
-
moderate
shikimate

shikimate synthesis decreases with increasing shikimate concentration. The relative activity halves at about 1.4 mM shikimate; shikimate synthesis decreases with increasing shikimate concentration. The relative activity halves at about 1.4 mM shikimate
shikimate
product inhibition, noncompetitive versus NADPH, competitive versus 3-dehydroshikimate
Zn2+

-
-
[2-[2-(dimethylamino)ethoxy]phenyl]methanol

A0A1K3RIC7
45% inhibition at 0.2 mM
[2-[2-(dimethylamino)ethoxy]phenyl]methanol
-
45% inhibition at 0.2 mM
additional information

screening for polyphenolc enzyme inhibitors, overview
-
additional information
-
screening for polyphenolc enzyme inhibitors, overview
-
additional information
not inhibitory: quinate; not inhibitory: quinate
-
additional information
not inhibitory: quinate; not inhibitory: quinate
-
additional information
-
not inhibitory: quinate; not inhibitory: quinate
-
additional information
-
no inhibition of paralogue HI0607 by EDTA
-
additional information
antibacterial activity of inhibitors, overview
-
additional information
-
antibacterial activity of inhibitors, overview
-
additional information
-
inhibitor screening
-
additional information
A0A1K3RIC7
structure-activity relationship studies on 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles as inhibitors of shikimate dehydrogenase, 3,6-disubstituted triazolothiadiazoles synthesis, overview. The compounds exhibit cytotoxicity against Vero and Hep-G2 cellss, IC50 and MIC values
-
additional information
screening for polyphenolc enzyme inhibitors, overview. No inhibition by gallic acid, epigallocatechin and epicatechin
-
additional information
-
screening for polyphenolc enzyme inhibitors, overview. No inhibition by gallic acid, epigallocatechin and epicatechin
-
additional information
-
no inhibition by curcumin
-
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0.00036 - 0.42
3-dehydroquinate
0.029 - 186
3-dehydroshikimate
0.05 - 0.087
shikimic acid
additional information
additional information
-
0.00036
3-dehydroquinate

pH 7.0, 30°C
0.42
3-dehydroquinate
pH 7.0, 30°C
0.029
3-dehydroshikimate

-
-
0.029
3-dehydroshikimate
wild-type enzyme, pH 7.3, 25°C
0.031
3-dehydroshikimate
pH 7.0, 25°C, recombinant AroE
0.031
3-dehydroshikimate
A0A1K3RIC7
pH 7.0, 25°C, with NADPH
0.044
3-dehydroshikimate
25°C, pH 7.3
0.046
3-dehydroshikimate
pH 7.0, 30°C, recombinant isozyme VvSDH3
0.076
3-dehydroshikimate
mutant K69A, pH 7.3, 25°C
0.157
3-dehydroshikimate
pH 7.0, 30°C, recombinant isozyme VvSDH1
0.2
3-dehydroshikimate
pH 7.0, 30°C
0.272
3-dehydroshikimate
pH 9.0, 30°C
0.272
3-dehydroshikimate
with NADPH, pH 8.6, 30°C
186
3-dehydroshikimate
pH 7.0, 30°C, recombinant isozyme VvSDH4
0.572
NAD+

pH 8.8, presence of 2 mM shikimate
1.083
NAD+
pH 8.8, presence of 2 mM quinate
2.9
NAD+
pH 8.0, 60°C, recombinant enzyme
5.4
NAD+
pH 8.8, presence of 2 mM shikimate
5.43
NAD+
pH 8.8, presence of 2 mM shikimate
5.43
NAD+
in the presence of shikimate
0.007
NADP+

-
-
0.0073
NADP+
pH 8.8, presence of 2 mM shikimate
0.0091
NADP+
-
pH 8.8, temperature not specified in the publication
0.0091
NADP+
pH 8.8, 25°C, with shikimate
0.0135
NADP+
with shikimate, pH 7.0, 25°C
0.017
NADP+
-
pH 7.5, 22°C, mutant K385A
0.022
NADP+
pH 7.0, 25°C, recombinant AroE
0.022
NADP+
-
pH 7.5, 22°C, mutant K385N/D423N
0.022
NADP+
A0A1K3RIC7
pH 7.0, 25°C, with shikimate
0.023
NADP+
pH 7.0, 30°C, recombinant isozyme VvSDH3
0.0295
NADP+
-
pH 9.0, 25°C
0.038
NADP+
pH 9.0, 30°C, recombinant isozyme VvSDH3
0.0424
NADP+
25°C, pH 9.0
0.0424
NADP+
with shikimate, pH 9.0, 25°C
0.04255
NADP+
-
pH not specified in the publication, 25°C
0.0426
NADP+
-
pH not specified in the publication, 25°C, with shikimate
0.053
NADP+
-
pH 7.5, 22°C, mutant K385N
0.0538
NADP+
pH 9.0, 30°C, recombinant isozyme VvSDH4
0.055
NADP+
pH 8.8, 25°C, with shikimate
0.056
NADP+
-
with shikimate, pH 9.0, 20°C
0.062
NADP+
-
mutant T381S, 22°C
0.063
NADP+
A0A1K3RIC7
pH 9.0, 25°C, with shikimate
0.068
NADP+
-
mutant H335A, 22°C
0.079
NADP+
-
pH 7.5, 22°C, mutant D423N
0.0928
NADP+
-
mutant T381A, 22°C
0.1
NADP+
pH 7.0, 25°C, with shikimate
0.107
NADP+
-
mutant T422S, 22°C
0.112
NADP+
pH 8.8, presence of 2 mM shikimate
0.112
NADP+
in the presence of shikimate
0.114
NADP+
-
pH 7.5, 22°C, mutant S338A
0.114
NADP+
pH 9.0, 30°C, recombinant isozyme VvSDH1
0.131
NADP+
-
pH 7.5, 22°C, wild-type DELTA88DHQ-SDH enzyme variant
0.131
NADP+
-
wild-type, 22°C
0.131
NADP+
pH 8.8, 22°C, with shikimate
0.132
NADP+
-
pH 7.5, 22°C, mutant Y550F
0.152
NADP+
-
pH 7.5, 22°C, mutant S336A
0.156
NADP+
-
mutant T407A, 22°C
0.157
NADP+
-
pH 7.5, 22°C, mutant Y550A
0.159
NADP+
-
mutant Q78L, 22°C
0.182
NADP+
pH 8.0, 60°C, recombinant enzyme
0.182
NADP+
-
with shikimate, pH 8.0, 25°C
0.19
NADP+
-
87°C, pH 7.3
0.19
NADP+
with shikimate, pH 7.3, 87°C
0.217
NADP+
pH 7.0, 30°C, recombinant isozyme VvSDH1
0.01
NADPH

pH 7.0, 25°C, recombinant AroE
0.011
NADPH
wild-type enzyme, pH 7.3, 25°C
0.03
NADPH
mutant K69A, pH 7.3, 25°C
0.031
NADPH
A0A1K3RIC7
pH 7.0, 25°C, with 3-dehydroshikimate
0.783
quinate

pH 8.8, presence of 2 mM NAD+
10.2
quinate
pH 9.0, 30°C
0.0046
shikimate

pH 8.8, presence of 2 mM NADP+
0.027
shikimate
pH 9.0, 30°C, recombinant isozyme VvSDH3
0.03
shikimate
A0A1K3RIC7
pH 9.0, 25°C, with NADP+
0.03746
shikimate
-
pH not specified in the publication, 25°C
0.0375
shikimate
-
pH not specified in the publication, 25°C, with NADP+
0.0424
shikimate
25°C, pH 9.0
0.0425
shikimate
with NADP+, pH 9.0, 25°C
0.05
shikimate
pH 7.0, 25°C, recombinant AroE
0.0502
shikimate
A0A1K3RIC7
pH 7.0, 25°C, with NADP+
0.0527
shikimate
-
pH 8.8, temperature not specified in the publication
0.0527
shikimate
pH 8.8, 25°C, with NADP+
0.063
shikimate
-
pH 9.0, 25°C
0.065
shikimate
-
with NADP+, pH 9.0, 20°C
0.07
shikimate
pH 9.0, 30°C, recombinant isozyme VvSDH1
0.073
shikimate
wild-type
0.073
shikimate
pH 7.0, 25°C, with NADP+
0.0786
shikimate
pH 8.8, presence of 2 mM NAD+
0.0786
shikimate
in the presence of 2 mM NAD+
0.105
shikimate
pH 8.8, presence of 2 mM NADP+
0.105
shikimate
in the presence of 2 mM NADP+
0.13
shikimate
22°C, pH 9.0
0.131
shikimate
-
pH 7.5, 22°C, mutant K385N/D423N
0.14
shikimate
pH 9.0, 30°C
0.14
shikimate
with NADP+, pH 9.0, 30°C
0.1468
shikimate
pH 9.0, 30°C, recombinant isozyme VvSDH4
0.148
shikimate
pH 8.0, 60°C, recombinant enzyme
0.148
shikimate
-
with NADP+, pH 8.0, 25°C
0.155
shikimate
pH 7.0, 30°C, recombinant isozyme VvSDH1
0.17
shikimate
-
87°C, pH 7.3
0.17
shikimate
with NADP+, pH 7.3, 87°C
0.178
shikimate
pH 8.8, 25°C, with NADP+
0.187
shikimate
pH 7.0, 30°C
0.19 - 0.28
shikimate
-
-
0.22
shikimate
-
2 KM-values
0.223
shikimate
-
pH 8.5, 22°C, with NADP+, isozyme Poptr1
0.223
shikimate
-
with NADP+, pH 8.5, 22°C, recombinant His-tagged Poptr1
0.227
shikimate
mutant Y211F
0.263
shikimate
-
pH 7.5, 22°C, mutant K385A
0.311
shikimate
with NADP+, pH 7.0, 25°C
0.321
shikimate
-
with NADP+, pH 8.5, 22°C, recombinant His-tagged Poptr1
0.346
shikimate
-
pH 8.5, 22°C, with NADP+, isozyme Poptr5
0.346
shikimate
-
with NAD+, pH 8.5, 22°C, recombinant His-tagged Poptr1
0.351
shikimate
pH 8.8, presence of 2 mM NAD+
0.422
shikimate
pH 7.0, 30°C, recombinant isozyme VvSDH3
0.427
shikimate
-
with NAD+, pH 8.5, 22°C, recombinant His-tagged Poptr1
0.459
shikimate
-
mutant T381S, 22°C
0.47
shikimate
-
pH 7.5, 22°C, mutant K385N
0.555
shikimate
-
pH 7.5, 22°C, mutant D423N
0.556
shikimate
-
mutant T381A, 22°C
0.626
shikimate
-
mutant H335A, 22°C
0.685
shikimate
-
pH 7.5, 22°C, wild-type DELTA88DHQ-SDH enzyme variant
0.685
shikimate
-
wild-type, 22°C
0.685
shikimate
pH 8.8, 22°C, with NADP+
0.91
shikimate
-
2 KM-values
0.92
shikimate
-
mutant Q78L, 22°C
1.022
shikimate
-
mutant T407A, 22°C
1.03
shikimate
-
pH 7.5, 22°C, mutant Y550A
1.06
shikimate
-
pH 7.5, 22°C, mutant Y550F
1.09
shikimate
-
mutant T422S, 22°C
4.2
shikimate
pH 8.8, presence of 2 mM NAD+
4.466
shikimate
-
mutant Q582L, 22°C
6.2
shikimate
-
pH 7.5, 22°C, mutant S338A
7.12
shikimate
-
mutant N406A, 22°C
8.74
shikimate
-
pH 7.5, 22°C, mutant S336A
46.6
shikimate
pH 10.0, 30°C
0.05
shikimic acid

-
NADP+
0.087
shikimic acid
-
NADP+
additional information
additional information

-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
Michaelis-Menten kinetics
-
additional information
additional information
-
kinetic profile of the recombinant AroE, overview
-
additional information
additional information
steady-state kinetics of recombinant AroE
-
additional information
additional information
-
steady-state kinetics of recombinant AroE
-
additional information
additional information
no measurable activity with NAD+
-
additional information
additional information
no measurable activity with NAD+
-
additional information
additional information
no measurable activity with NAD+
-
additional information
additional information
no measurable activity with NAD+
-
additional information
additional information
no measurable activity with NAD+
-
additional information
additional information
no measurable activity with NADH+
-
additional information
additional information
no measurable activity with NADH+
-
additional information
additional information
no measurable activity with NADH+
-
additional information
additional information
no measurable activity with NADH+
-
additional information
additional information
no measurable activity with NADH+
-
additional information
additional information
no measurable activity with quinate
-
additional information
additional information
no measurable activity with quinate
-
additional information
additional information
no measurable activity with quinate
-
additional information
additional information
no measurable activity with quinate
-
additional information
additional information
no measurable activity with quinate
-
additional information
additional information
no measurable activity with shikimate
-
additional information
additional information
no measurable activity with shikimate
-
additional information
additional information
no measurable activity with shikimate
-
additional information
additional information
no measurable activity with shikimate
-
additional information
additional information
no measurable activity with shikimate
-
additional information
additional information
steady-state kinetics of wild-type and mutant enzymes, overview
-
additional information
additional information
-
steady-state kinetics of wild-type and mutant enzymes, overview
-
additional information
additional information
-
the enzyme shows Michaelis-Menten kinetics toward both substrates shikimate and NADP+, kinetic analysis, sequential random mechanism, overview
-
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0.36 - 114
3-dehydroquinate
0.078 - 329
3-dehydroshikimate
additional information
additional information
-
0.36
3-dehydroquinate

pH 7.0, 30°C
114
3-dehydroquinate
pH 7.0, 30°C
0.078
3-dehydroshikimate

25°C, pH 7.3
0.73
3-dehydroshikimate
mutant K69A, pH 7.3, 25°C
8.62
3-dehydroshikimate
pH 7.0, 30°C, recombinant isozyme VvSDH3
49
3-dehydroshikimate
pH 7.0, 25°C, recombinant AroE
49
3-dehydroshikimate
A0A1K3RIC7
pH 7.0, 25°C, with NADPH
50
3-dehydroshikimate
wild-type enzyme, pH 7.3, 25°C
95.85
3-dehydroshikimate
pH 7.0, 30°C, recombinant isozyme VvSDH1
118
3-dehydroshikimate
pH 9.0, 30°C
118
3-dehydroshikimate
with NADPH, pH 8.6, 30°C
329
3-dehydroshikimate
pH 7.0, 30°C
5.2
NAD+

pH 8.0, 60°C, recombinant enzyme
6.72
NAD+
pH 8.8, presence of 2 mM shikimate
6.72
NAD+
in the presence of shikimate
40.7
NAD+
pH 8.8, presence of 2 mM quinate
61.1
NAD+
pH 8.8, presence of 2 mM shikimate
97.1
NAD+
pH 8.8, presence of 2 mM shikimate
97.1
NAD+
in the presence of shikimate
0.008
NADP+

-
pH 7.5, 22°C, mutant K385A
0.036
NADP+
-
pH 7.5, 22°C, mutant K385N/D423N
0.066
NADP+
-
pH 7.5, 22°C, mutant K385N
0.077
NADP+
in the presence of quinate
0.092
NADP+
-
pH 7.5, 22°C, mutant D423N
1.86
NADP+
-
pH 7.5, 22°C, mutant Y550A
2.77
NADP+
pH 8.8, 25°C, with shikimate
3.11
NADP+
-
pH 7.5, 22°C, mutant Y550F
4.51
NADP+
-
mutant Q78L, 22°C
5.3
NADP+
pH 8.8, presence of 2 mM shikimate
5.3
NADP+
in the presence of shikimate
5.9
NADP+
pH 7.0, 25°C, recombinant AroE
5.9
NADP+
A0A1K3RIC7
pH 7.0, 25°C, with shikimate
7.1
NADP+
pH 8.0, 60°C, recombinant enzyme
7.1
NADP+
-
with shikimate, pH 8.0, 25°C
11.2
NADP+
-
pH 7.5, 22°C, mutant S338A
15.1
NADP+
-
mutant T381A, 22°C
19.78
NADP+
pH 7.0, 30°C, recombinant isozyme VvSDH3
22.8
NADP+
pH 7.0, 25°C, with shikimate
26.11
NADP+
pH 9.0, 30°C, recombinant isozyme VvSDH3
28.89
NADP+
pH 9.0, 30°C, recombinant isozyme VvSDH4
30.7
NADP+
pH 7.0, 30°C, recombinant isozyme VvSDH1
34
NADP+
-
mutant H335A, 22°C
43.3
NADP+
-
mutant T422S, 22°C
52.1
NADP+
-
mutant T407A, 22°C
52.9
NADP+
-
pH 7.5, 22°C, mutant S336A
55.5
NADP+
with shikimate, pH 9.0, 25°C
105
NADP+
-
mutant T381S, 22°C
146.2
NADP+
-
pH not specified in the publication, 25°C
146.2
NADP+
-
pH not specified in the publication, 25°C, with shikimate
237
NADP+
-
with shikimate, pH 9.0, 20°C
239
NADP+
pH 9.0, 30°C, recombinant isozyme VvSDH1
261.5
NADP+
pH 8.8, presence of 2 mM shikimate
261.5
NADP+
in the presence of shikimate
302
NADP+
pH 8.8, 25°C, with shikimate
390
NADP+
with shikimate, pH 7.3, 87°C
399
NADP+
-
pH 7.5, 22°C, wild-type DELTA88DHQ-SDH enzyme variant
399
NADP+
-
wild-type, 22°C
399
NADP+
pH 8.8, 22°C, with shikimate
399
NADP+
A0A1K3RIC7
pH 9.0, 25°C, with shikimate
45
NADPH

pH 7.0, 25°C, recombinant AroE
45
NADPH
A0A1K3RIC7
pH 7.0, 25°C, with 3-dehydroshikimate
0.16
quinate

in the presence of 2 mM NADP+
37.7
quinate
pH 8.8, presence of 2 mM NAD+
61.9
quinate
pH 9.0, 30°C
0.013
shikimate

-
pH 7.5, 22°C, mutant K385A
0.043
shikimate
-
pH 7.5, 22°C, mutant K385N/D423N
0.063
shikimate
-
pH 7.5, 22°C, mutant K385N
0.066
shikimate
mutant Y211F
0.121
shikimate
-
pH 7.5, 22°C, mutant D423N
0.174
shikimate
-
mutant N406A, 22°C
0.346
shikimate
-
mutant Q582L, 22°C
1.5
shikimate
with NADP+, pH 7.0, 25°C
1.99
shikimate
pH 8.8, presence of 2 mM NAD+
1.99
shikimate
in the presence of 2 mM NAD+
2.1
shikimate
-
pH 7.5, 22°C, mutant Y550A
2.78
shikimate
pH 8.8, 25°C, with NADP+
2.78
shikimate
-
pH 8.8, temperature not specified in the publication
3.9
shikimate
-
pH 7.5, 22°C, mutant Y550F
5.16
shikimate
pH 9.0, 30°C, recombinant isozyme VvSDH3
5.8
shikimate
pH 8.8, presence of 2 mM NADP+
5.8
shikimate
in the presence of 2 mM NADP+
7.3
shikimate
-
mutant Q78L, 22°C
7.56
shikimate
pH 7.0, 30°C, recombinant isozyme VvSDH3
7.7
shikimate
pH 8.0, 60°C, recombinant enzyme
7.7
shikimate
-
with NADP+, pH 8.0, 25°C
8.2
shikimate
pH 7.0, 25°C, recombinant AroE
8.2
shikimate
A0A1K3RIC7
pH 7.0, 25°C, with NADP+
11.72
shikimate
pH 7.0, 30°C, recombinant isozyme VvSDH1
16.8
shikimate
-
mutant T381A, 22°C
22.8
shikimate
pH 7.0, 25°C, with NADP+
26.12
shikimate
pH 9.0, 30°C, recombinant isozyme VvSDH4
31
shikimate
pH 7.0, 30°C
31.2
shikimate
pH 8.8, presence of 2 mM NAD+
31.2
shikimate
in the presence of 2 mM NAD+
33.2
shikimate
-
pH 7.5, 22°C, mutant S338A
42
shikimate
-
mutant H335A, 22°C
46.3
shikimate
-
mutant T422S, 22°C
55
shikimate
25°C, pH 9.0
55.5
shikimate
with NADP+, pH 9.0, 25°C
55.7
shikimate
pH 8.8, presence of 2 mM NAD+
66.6
shikimate
-
mutant T407A, 22°C
85.2
shikimate
pH 10.0, 30°C
94.55
shikimate
pH 9.0, 30°C, recombinant isozyme VvSDH1
114
shikimate
-
mutant T381S, 22°C
135.8
shikimate
-
pH not specified in the publication, 25°C
135.8
shikimate
-
pH not specified in the publication, 25°C, with NADP+
140
shikimate
-
pH 7.5, 22°C, mutant S336A
234
shikimate
pH 9.0, 30°C
234
shikimate
with NADP+, pH 9.0, 30°C
237
shikimate
-
with NADP+, pH 9.0, 20°C
266.2
shikimate
pH 8.8, presence of 2 mM NADP+
266.2
shikimate
in the presence of 2 mM NADP+
307
shikimate
pH 8.8, 25°C, with NADP+
399
shikimate
-
pH 9.0, 25°C
399
shikimate
A0A1K3RIC7
pH 9.0, 25°C, with NADP+
428
shikimate
-
pH 7.5, 22°C, wild-type DELTA88DHQ-SDH enzyme variant
428
shikimate
-
wild-type, 22°C
428
shikimate
pH 8.8, 22°C, with NADP+
additional information
additional information

no measurable activity with NAD+
-
additional information
additional information
no measurable activity with NAD+
-
additional information
additional information
no measurable activity with NAD+
-
additional information
additional information
no measurable activity with NAD+
-
additional information
additional information
no measurable activity with NAD+
-
additional information
additional information
no measurable activity with NADH
-
additional information
additional information
no measurable activity with NADH
-
additional information
additional information
no measurable activity with NADH
-
additional information
additional information
no measurable activity with NADH
-
additional information
additional information
no measurable activity with NADH
-
additional information
additional information
no measurable activity with NADH+
-
additional information
additional information
no measurable activity with NADH+
-
additional information
additional information
no measurable activity with NADH+
-
additional information
additional information
no measurable activity with NADH+
-
additional information
additional information
no measurable activity with NADH+
-
additional information
additional information
no measurable activity with quinate
-
additional information
additional information
no measurable activity with quinate
-
additional information
additional information
no measurable activity with quinate
-
additional information
additional information
no measurable activity with quinate
-
additional information
additional information
no measurable activity with quinate
-
additional information
additional information
no measurable activity with shikimate
-
additional information
additional information
no measurable activity with shikimate
-
additional information
additional information
no measurable activity with shikimate
-
additional information
additional information
no measurable activity with shikimate
-
additional information
additional information
no measurable activity with shikimate
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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