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Information on EC 1.1.1.243 - carveol dehydrogenase
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EC Tree
1.1.1.243 carveol dehydrogenaseSpecify your search results
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
carveol dehydrogenase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Cdh
dehydrogenase, (-)-trans-carveol
-
-
-
-
Cdh
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
(-)-trans-carveol + NADP+ = (-)-carvone + NADPH + H+
-
-
-
-
(-)-trans-carveol + NADP+ = (-)-carvone + NADPH + H+
steroselective conversion of (6S)-carveol stereomers from a diastereomeric mixture of (4R)- or (4S)-carveol
-
(-)-trans-carveol + NADP+ = (-)-carvone + NADPH + H+
steroselective conversion of (6S)-carveol stereomers from a diastereomeric mixture of (4R)- or (4S)-carveol
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
redox reaction
-
-
-
-
reduction
-
-
-
-
oxidation
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
KEGG
-
-
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SYSTEMATIC NAME
IUBMB Comments
(-)-trans-carveol:NADP+ oxidoreductase
-
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CAS REGISTRY NUMBER
COMMENTARY
122653-66-1
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(1R,2R,4S)-limonene-1,2-diol + NAD+
?
-
15% of activity with (4S,6S)-trans-carveol, enzyme uses dichlorophenolindophenol as artificial electron acceptor
-
ir
(1S,2S,4R)-limonene-1,2-diol + NAD+
?
-
25% of activity with (4S,6S)-trans-carveol, enzyme uses dichlorophenolindophenol as artificial electron acceptor
-
ir
(4R,6S)-dihydrocarveol + NAD+
(4R)-carvone + NADH
-
20% of activity with (4S,6S)-trans-carveol, enzyme uses dichlorophenolindophenol as artificial electron acceptor
-
ir
(4S,6S)-dihydrocarveol + NAD+
(4S)-carvone + NADH
-
20% of activity with (4S,6S)-trans-carveol, enzyme uses dichlorophenolindophenol as artificial electron acceptor
-
ir
(R)-indanol + NAD+
indanone + NADH
-
13% of activity with (4S,6S)-trans-carveol, enzyme uses dichlorophenolindophenol as artificial electron acceptor
-
ir
(S)-indanol + NAD+
indanon + NADH
-
30% of activity with (4S,6S)-trans-carveol, enzyme uses dichlorophenolindophenol as artificial electron acceptor
-
ir
2-ethylcyclohexanol + NAD+
2-ethylcyclohexanone + NADH
-
110% of activity with (4S,6S)-trans-carveol, enzyme uses dichlorophenolindophenol as artificial electron acceptor
-
ir
2-methylcyclohexanol + NAD+
2-methylcyclohexanone + NADH
-
100% of activity with (4S,6S)-trans-carveol, enzyme uses dichlorophenolindophenol as artificial electron acceptor
-
ir
3,3,5,5-tetramethylcyclohexanol + NAD+
3,3,5,5-tetramethylcyclohexanone + NADH
-
55% of activity with (4S,6S)-trans-carveol, enzyme uses dichlorophenolindophenol as artificial electron acceptor
-
ir
3,5,5-trimethylcyclohex-2-en-1-ol + NAD+
3,5,5-trimethylcyclohex-2-en-1-one + NADH
-
115% of activity with (4S,6S)-trans-carveol, enzyme uses dichlorophenolindophenol as artificial electron acceptor
-
ir
4-ethylcyclohexanol + NAD+
4-ethylcyclohexanone + NADH
-
40% of activity with (4S,6S)-trans-carveol, enzyme uses dichlorophenolindophenol as artificial electron acceptor
-
ir
4-methylcyclohexanol + NAD+
4-methylcyclohexanone + NADH
-
35% of activity with (4S,6S)-trans-carveol, enzyme uses dichlorophenolindophenol as artificial electron acceptor
-
ir
cyclohex-2-ene-1-ol + NAD+
cyclohex-2-ene-1-one + NADH
-
10% of activity with (4S,6S)-trans-carveol, enzyme uses dichlorophenolindophenol as artificial electron acceptor
-
ir
sobrerol + NAD+
?
-
20% of activity with (4S,6S)-trans-carveol, enzyme uses dichlorophenolindophenol as artificial electron acceptor
-
ir
(-)-trans carveol + NAD+
(-)-carvone + NADH
-
stereospecific for the trans-form
-
-
?
(-)-trans carveol + NAD+
(-)-carvone + NADH
-
stereospecific for the trans-form
-
-
?
(-)-trans carveol + NADP+
(-)-carvone + NADPH
-
last step of (-)-carvone biosynthesis
-
-
?
(-)-trans carveol + NADP+
(-)-carvone + NADPH
-
last step of (-)-carvone biosynthesis
-
-
?
(-)-trans carveol + NADP+
(-)-carvone + NADPH
-
last step of (-)-carvone biosynthesis
-
-
?
(4R,6S)-trans-carveol + NAD+
(4R)-carvone + NADH
-
95% of activity with (4S,6S)-trans-carveol, enzyme uses dichlorophenolindophenol as artificial electron acceptor
-
ir
(4R,6S)-trans-carveol + NAD+
(4R)-carvone + NADH
-
enzyme uses dichlorophenolindophenol as artificial electron acceptor, physiological acceptor not known
-
ir
(4R,6S)-trans-carveol + NAD+
(4R)-carvone + NADH
-
95% of activity with (4S,6S)-trans-carveol, enzyme uses dichlorophenolindophenol as artificial electron acceptor
-
ir
(4R,6S)-trans-carveol + NAD+
(4R)-carvone + NADH
-
enzyme uses dichlorophenolindophenol as artificial electron acceptor, physiological acceptor not known
-
ir
(4R,6S)-trans-carveol + NADP+
(4R)-carvone + NADPH
-
monoterpene synthesis in mints
-
?
(4S,6RS)-carveol + NAD+
(4S)-carvone + NADH
-
enzyme uses dichlorophenolindophenol as artificial electron acceptor
-
ir
(4S,6RS)-carveol + NAD+
(4S)-carvone + NADH
-
enzyme uses dichlorophenolindophenol as artificial electron acceptor
-
ir
3-methylcyclohexanol + NAD+
3-methylcyclohexanone + NADH
-
165% of activity with (4S,6S)-trans-carveol, enzyme uses dichlorophenolindophenol as artificial electron acceptor
-
ir
3-methylcyclohexanol + NAD+
3-methylcyclohexanone + NADH
-
165% of activity with (4S,6S)-trans-carveol, enzyme uses dichlorophenolindophenol as artificial electron acceptor
-
ir
cyclohexanol + NAD+
cyclohexanone + NADH
-
15% of activity with (4S,6S)-trans-carveol, enzyme uses dichlorophenolindophenol as artificial electron acceptor
-
ir
cyclohexanol + NAD+
cyclohexanone + NADH
-
15% of activity with (4S,6S)-trans-carveol, enzyme uses dichlorophenolindophenol as artificial electron acceptor
-
ir
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(4R,6S)-trans-carveol + NADP+
(4R)-carvone + NADPH
-
monoterpene synthesis in mints
-
?
(-)-trans carveol + NADP+
(-)-carvone + NADPH
-
last step of (-)-carvone biosynthesis
-
-
?
(-)-trans carveol + NADP+
(-)-carvone + NADPH
-
last step of (-)-carvone biosynthesis
-
-
?
(-)-trans carveol + NADP+
(-)-carvone + NADPH
-
last step of (-)-carvone biosynthesis
-
-
?
(4R,6S)-trans-carveol + NAD+
(4R)-carvone + NADH
-
enzyme uses dichlorophenolindophenol as artificial electron acceptor, physiological acceptor not known
-
ir
(4R,6S)-trans-carveol + NAD+
(4R)-carvone + NADH
-
enzyme uses dichlorophenolindophenol as artificial electron acceptor, physiological acceptor not known
-
ir
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
NAD+
-
each monomer of carveol dehydrogenase contains one tightly bound NAD(H) molecule
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Cyclohexanol
-
induction during growth, slightly more effective than (+)-limonene
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
0.002
0.005
0.009
-
NAD+-dependent (4S)-carveol dehydrogenase, activity in extracts of cells grown on (4R)-limonene
0.014
0.017
-
NAD+-dependent (4R)-carveol dehydrogenase, activity in extracts of cells grown on (4R)-limonene
0.021
-
NAD+-dependent(4S)-carveol dehydrogenase, activity in extracts of cells grown on (4R)-carveol
0.026
-
activity in whole cells grown on limonene, biphasic assay system consisting of 20 ml phosphate buffer and 4 ml iso-octane
0.045
-
NAD+-dependent (4R)-carveol dehydrogenase, activity in extracts of cells grown on (4R)-carveol
0.09
-
dichlorophenolindophenol-dependent(4R)-carveol dehydrogenase, activity in extracts of cells grown on (4R)-limonene
0.105
-
dichlorophenolindophenol+-dependent (4S)-carveol dehydrogenase, activity in extracts of cells grown on (4R)-limonene
0.002
-
NADP+-dependent (4R)-carveol dehydrogenase, activity in extracts of cells grown on (4R)-limonene
0.002
-
NADP+-dependent (4S)-carveol dehydrogenase, activity in extracts of cells grown on (4R)-carveol
0.005
-
NADP+-dependent (4S)-carveol dehydrogenase, activity in extracts of cells grown on (4R)-limonene
0.005
-
NADP+-dependent (4R)-carveol dehydrogenase, activity in extracts of cells grown on (4R)-carveol
0.014
-
dichlorphenolindophenol+-dependent(4R)-carveol dehydrogenase, activity in extracts of cells grown on (4R)-carveol
0.014
-
dichlorophenolindophenol-dependent (4S)-carveol dehydrogenase, activity in extracts of cells grown on (4R)-carveol
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
6 - 50
-
gradual increase in specific activity from 0.55 micromol/min mg to 2.85 micromol/min mg
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
enzyme is induced after growth on limonene or carveol
-
-
brenda
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
additional information
additional information
-
growth on (+)-limonene or cyclohexanol induces the enzyme
brenda
additional information
-
growth on (+)-limonene or cyclohexanol induces the enzyme
-
brenda
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). ISPD_MENPI
265
0
27191
Swiss-Prot
Secretory Pathway (Reliability: 4)
A0A259US84_9FIRM
654
0
74078
TrEMBL
-
A0A259UP01_9FIRM
691
0
78477
TrEMBL
-
A0A259USU3_9FIRM
622
0
67462
TrEMBL
-
A0A259UE55_9FIRM
683
0
76771
TrEMBL
-
A0A151AMR8_9CLOT
592
0
67745
TrEMBL
-
A0A259UDF5_9FIRM
687
0
76256
TrEMBL
-
A0A1U7MIU5_9FIRM
601
0
68007
TrEMBL
-
A0A259U760_9FIRM
467
0
52259
TrEMBL
-
A0A259UDI7_9FIRM
476
0
53398
TrEMBL
-
A0A259UWD0_9FIRM
642
0
70999
TrEMBL
-
A0A151B3G4_9CLOT
431
0
49278
TrEMBL
-
A0A251UTJ2_HELAN
271
0
28731
TrEMBL
other Location (Reliability: 2)
A0A259UGG9_9FIRM
511
0
57322
TrEMBL
-
A0A0L6Z7Q9_9CLOT
474
0
53971
TrEMBL
-
A0A259U8N5_9FIRM
633
0
70266
TrEMBL
-
A0A1U7MBW2_9FIRM
638
0
70213
TrEMBL
-
A0A1U7MIS5_9FIRM
618
0
70067
TrEMBL
-
A0A151ALB6_9CLOT
446
0
51062
TrEMBL
-
A0A1U7MIF3_9FIRM
558
0
62938
TrEMBL
-
A0A1J5PPM2_9ZZZZ
168
0
18421
TrEMBL
other Location (Reliability: 3)
A0A259U8U6_9FIRM
695
0
77743
TrEMBL
-
I7FPA9_MYCS2
Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)
295
0
31129
TrEMBL
-
A0A259U4X5_9FIRM
637
0
70718
TrEMBL
-
A0A0L6Z833_9CLOT
486
0
55403
TrEMBL
-
A0A1U7MCR5_9FIRM
637
0
70818
TrEMBL
-
A0A0L6Z6N1_9CLOT
477
0
54405
TrEMBL
-
A0A259UUL8_9FIRM
474
0
54023
TrEMBL
-
A0A1U7MB88_9FIRM
635
0
71335
TrEMBL
-
A0A1U7MB55_9FIRM
627
0
69921
TrEMBL
-
A0A086ZNB2_9BIFI
433
0
46548
TrEMBL
-
A0A0L6Z642_9CLOT
467
0
53231
TrEMBL
-
A0A259UBX6_9FIRM
634
0
70751
TrEMBL
-
A0A259UGW2_9FIRM
641
0
71585
TrEMBL
-
E5AU78_MYCRK
Mycetohabitans rhizoxinica (strain DSM 19002 / CIP 109453 / HKI 454)
274
0
28842
TrEMBL
-
A0A1U7M748_TISCR
583
0
66612
TrEMBL
-
A0A259U8Y6_9FIRM
707
0
80002
TrEMBL
-
A0A0L6Z703_9CLOT
478
0
54757
TrEMBL
-
A0A259UT95_9FIRM
478
0
54204
TrEMBL
-
A0A259U8H2_9FIRM
668
0
74199
TrEMBL
-
A0A259U483_9FIRM
637
0
71729
TrEMBL
-
A0A1U7M8V9_TISCR
435
0
50088
TrEMBL
-
A0A087A5K8_9BIFI
440
1
47169
TrEMBL
-
A0A259UNH7_9FIRM
623
0
68840
TrEMBL
-
A0A259UDW0_9FIRM
714
0
80579
TrEMBL
-
A0A259URT8_9FIRM
600
0
67811
TrEMBL
-
A0A1J5Q123_9ZZZZ
204
0
22453
TrEMBL
other Location (Reliability: 2)
A0A0L6Z6L1_9CLOT
636
0
71325
TrEMBL
-
A0A259UW73_9FIRM
638
0
72020
TrEMBL
-
A0A259UN71_9FIRM
323
0
36551
TrEMBL
-
Show AA Sequence and Transmembrane Helices (104 entries)
Please use the AA Sequence and Transmembrane Helices Search for a specific query.
Please use the AA Sequence and Transmembrane Helices Search for a specific query.
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
tetramer
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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
to 1.95 A resolution. STD-NMR demonstrates binding of the potential substrate carveol, the potential product carvone, the inhibitor tricyclazol, and external redox partner 2,6-dichloroindophenol. The enzyme appears to contain a non-exchangeable NAD cofactor and may rely on an external redox partner, rather than cofactor exchange, for multiple turnover
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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OXIDATION STABILITY
ORGANISM
UNIPROT
LITERATURE
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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CLONED (Commentary)