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IUBMB Comments Si -specific with respect to NADPH. Also reduces 8-oxodeoxy-coformycin to the nucleoside antibiotic deoxycoformycin.
Synonyms
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8-ketodCF reductase
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8-ketodeoxycoformycin reductase
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coformycin + NADP+ = 8-oxocoformycin + NADPH + H+
coformycin + NADP+ = 8-oxocoformycin + NADPH + H+
possible mechanism
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coformycin + NADP+ = 8-oxocoformycin + NADPH + H+
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coformycin:NADP+ 8-oxidoreductase
Si-specific with respect to NADPH. Also reduces 8-oxodeoxy-coformycin to the nucleoside antibiotic deoxycoformycin.
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8-ketocoformycin + NADPH
coformycin + NADP+
8-ketodeoxycoformycin + NADPH
2'-deoxycoformycin + NADP+
8-ketocoformycin + NADPH
coformycin + NADP+
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Substrates: stereospecifically reduces the 8-keto group of the ketonucleoside substrate to a hydroxyl group with the R configuration at C-8
r
8-ketocoformycin + NADPH
coformycin + NADP+
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Substrates: production of the antibiotic coformycin
r
8-ketodeoxycoformycin + NADPH
2'-deoxycoformycin + NADP+
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Substrates: stereospecifically reduces the 8-keto group of the ketonucleoside substrate to a hydroxyl group with the R configuration at C-8
r
8-ketodeoxycoformycin + NADPH
2'-deoxycoformycin + NADP+
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Substrates: production of the antibiotic 2'-deoxycoformycin
r
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8-ketocoformycin + NADPH
coformycin + NADP+
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Substrates: production of the antibiotic coformycin
r
8-ketodeoxycoformycin + NADPH
2'-deoxycoformycin + NADP+
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Substrates: production of the antibiotic 2'-deoxycoformycin
r
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NADH
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NADPH is 25-fold higher active than NADH
NADPH
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B-specific with respect to NADPH, 25-fold higher activity than with NADH
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0.15
8-Ketocoformycin
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0.25
8-Ketodeoxycoformycin
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Highest Expressing Human Cell Lines
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C0RMG6_BRUMB
Brucella melitensis biotype 2 (strain ATCC 23457)
234
0
26671
TrEMBL
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C0GB02_9HYPH
234
0
26671
TrEMBL
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C4IWI1_BRUAO
234
0
26671
TrEMBL
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Hanvey, J.C.; Hawkins, E.S.; Baker, D.C.; Suhadolnik, R.J.
8-Ketodeoxycoformycin and 8-ketocoformycin as intermediates in the biosynthesis of 2-deoxycoformycin and coformycin
Biochemistry
27
5790-5795
1988
Streptomyces antibioticus
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