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IUBMB CommentsThe enzyme from Corynebacterium cyclohexanicum is highly specific for the trans-4-hydroxy derivative.
The enzyme appears in viruses and cellular organisms
Synonyms
4-hydroxycyclohexanecarboxylate dehydrogenase,
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trans-4-hydroxycyclohexanecarboxylate dehydrogenase
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trans-4-hydroxycyclohexanecarboxylate + NAD+ = 4-oxocyclohexanecarboxylate + NADH + H+
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trans-4-hydroxycyclohexanecarboxylate:NAD+ 4-oxidoreductase
The enzyme from Corynebacterium cyclohexanicum is highly specific for the trans-4-hydroxy derivative.
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trans-4-hydroxycyclohexanecarboxylate + NAD+
4-oxocyclohexanecarboxylate + NADH
trans-4-hydroxycyclohexanecarboxylate + NAD+
4-oxocyclohexanecarboxylate + NADH
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trans-4-hydroxycyclohexanecarboxylate + NAD+
4-oxocyclohexanecarboxylate + NADH
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enzyme of the oxidative branch of the 2-hydroxy-4-carboxymucoic semialdehyde-cleaving pathway
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trans-4-hydroxycyclohexanecarboxylate + NAD+
4-oxocyclohexanecarboxylate + NADH
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trans-4-hydroxycyclohexanecarboxylate + NAD+
4-oxocyclohexanecarboxylate + NADH
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enzyme of the oxidative branch of the 2-hydroxy-4-carboxymucoic semialdehyde-cleaving pathway
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trans-4-hydroxycyclohexanecarboxylate + NAD+
4-oxocyclohexanecarboxylate + NADH
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trans-4-hydroxycyclohexanecarboxylate + NAD+
4-oxocyclohexanecarboxylate + NADH
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higher specific activities assayed for reverse reaction
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trans-4-hydroxycyclohexanecarboxylate + NAD+
4-oxocyclohexanecarboxylate + NADH
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highly specific for trans isomer
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trans-4-hydroxycyclohexanecarboxylate + NAD+
4-oxocyclohexanecarboxylate + NADH
trans-4-hydroxycyclohexanecarboxylate + NAD+
4-oxocyclohexanecarboxylate + NADH
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enzyme of the oxidative branch of the 2-hydroxy-4-carboxymucoic semialdehyde-cleaving pathway
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trans-4-hydroxycyclohexanecarboxylate + NAD+
4-oxocyclohexanecarboxylate + NADH
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enzyme of the oxidative branch of the 2-hydroxy-4-carboxymucoic semialdehyde-cleaving pathway
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trans-4-hydroxycyclohexanecarboxylate + NAD+
4-oxocyclohexanecarboxylate + NADH
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NAD+
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very specific, no activity with NADP+
NAD+
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very specific, no activity with NADP+
NADH
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very specific, no activity with NADPH
NADH
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very specific, no activity with NADPH
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iodoacetamide
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slight inhibition
iodoacetic acid
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slight inhibition
N-bromosuccinimide
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strong inhibition
p-hydroxymercuribenzoate
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slight inhibition
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0.5
4-Oxocyclohexanecarboxylate
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0.51
trans-4-hydroxycyclohexanecarboxylate
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1.48
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crude extract, NADH oxidation
104.1
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purified enzyme, NADH oxidation
40
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purified enzyme, NAD reduction
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5.8 - 7.2
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NADH oxidation, depending on the buffer system
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brenda
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brenda
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brenda
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dimer
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2 * 27600, gel filtration, SDS-PAGE
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Obata, H.; Uebayasi, M.; Kaneda, T.
Purification and properties of 4-hydroxycyclohexanecarboxylate dehydrogenase from Corynebacterium cyclohexanicum
Eur. J. Biochem.
174
451-458
1988
Corynebacterium cyclohexanicum
brenda
Taylor, D.G.; Trudgill, P.
Metabolism of cyclohexane caroxylic acid by Alcaligenes strain W1
J. Bacteriol.
5
401-411
1978
Alcaligenes sp., Alcaligenes sp. W1
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brenda
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1.1.1.226 4-hydroxycyclohexanecarboxylate dehydrogenase
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