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Information on EC 1.1.1.219 - dihydroflavonol 4-reductase

for references in articles please use BRENDA:EC1.1.1.219

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IUBMB Comments

This plant enzyme, involved in the biosynthesis of anthocyanidins, is known to act on (+)-dihydrokaempferol, (+)-taxifolin, and (+)-dihydromyricetin, although some enzymes may act only on a subset of these compounds. Each dihydroflavonol is reduced to the corresponding cis-flavan-3,4-diol. NAD+ can act instead of NADP+, but more slowly.

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

Synonyms
dihydroflavonol 4-reductase, flavonoid 3'-hydroxylase, dihydroflavonol reductase, dihydroflavonol-4-reductase, csdfr, tadfr, mcdfr, bo9g058630, pgdfr, ibdfr, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a (2R,3S,4S)-leucoanthocyanidin + NADP+ = a (2R,3R)-dihydroflavonol + NADPH + H+
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
leucodelphinidin biosynthesis, leucopelargonidin and leucocyanidin biosynthesis