Reference on EC 1.1.1.145 - 3beta-hydroxy-DELTA5-steroid dehydrogenase and Organism(s) Homo sapiens
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Thomas, J.L.; Strickler, R.C.; Myers, R.P.; Covey, D.F
Affinity labeling of human placental 3beta-hydroxy-DELTA5-steroid dehydrogenase and steroid delta-isomerase: evidence for bifunctional catalysis by a different conformation of the same protein for each enzyme activity
Biochemistry
31
5522-5527
1992
Homo sapiens
Rabe, T.; Brandstetter, K.; Kellermann, J.; Runnebaum, B.
Partial characterization of placental 3beta-hydroxysteroid dehydrogenase (EC 1.1.1.145), delta 4-5isomerase (EC 5.3.3.1) in human term placental mitochondria
J. Steroid Biochem.
17
427-433
1982
Homo sapiens
Huang, Y.W.; Lu, M.L.; Qi, H.; Lin, S.X.
Membrane-bound human 3beta-hydroxysteroid dehydrogenase: overexpression with his-tag using a baculvirus system and single-step purification
Protein Expr. Purif.
18
169-174
2000
Homo sapiens
Thomas, J.L.; Mason, J.I.; Blanco, G.; Veisaga, M.L.
The engineered, cytosolic form of human type I 3beta-hydroxysteroid dehydrogenase/isomerase: purification, characterization and crystallization
J. Mol. Endocrinol.
27
77-83
2001
Homo sapiens
Thomas, J.L.; Evans, B.W.; Blanco, G.; Mason, J.I.; Strickler, R.C.
Creation of a fully active, cytosolic form of human type I 3beta-hydroxysteroid dehydrogenase/isomerase by the deletion of a membrane-spanning domain
J. Mol. Endocrinol.
23
231-239
1999
Homo sapiens
Riley, S.C.; Dupont, E.; Walton, J.C.; Luu-The, V.; Labrie, F.; Pelletier, G.; Challis, J.R.
Immunohistochemical localization of 3beta-hydroxy-5-ene-steroid dehydrogenase/DELTA5-DELTA4 isomerase in human placenta and fetal membranes throughout gestation
J. Clin. Endocrinol.
75
956-961
1992
Homo sapiens
Suzuki, T.; Sasana, H.; Andersson, S.; Mason, J.I.
3beta-Hydroxysteroid dehydrogenase/DELTA5---4-isomerase activity associated with the human 17beta-hydroxysteroid dehydrogenase type 2 isoform
J. Clin. Endocrinol.
85
3669-3672
2000
Homo sapiens
Labrie, F.; Simard, J.; Luu-The, V.; Pelletier, G.; Belanger, A.; Lachance, Y.; Zhao, H.F.; Labrie, C.; Breton, N.; de Launoit, Y.; et al.
Structure and tissue-specific expression of 3beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase genes in human and rat classical and peripheral steroidogenic tissues
J. Steroid Biochem. Mol. Biol.
41
421-435
1992
Homo sapiens, Rattus norvegicus
Nash, W.E.; Mercer, R.W.; Blanco, G.; Strickler, R.C.; Mason, J.I.; Thomas, J.L.
Over-expression of human type I (placental) 3beta-hydroxy-5-ene-steroid dehydrogenase/isomerase in insect cells infected with recombinant baculovirus
J. Steroid Biochem. Mol. Biol.
50
235-240
1994
Homo sapiens
Thomas, J.L.; Mason, J.I.; Brandt, S.; Norris, W.
Differences in substrate and inhibitor kinetics of human type 1 and type 2 3beta-hydroxysteroid dehydrogenase are explained by the type 1 mutant, H156Y
Endocr. Res.
28
471-475
2002
Homo sapiens
Thomas, J.L.; Mason, J.I.; Brandt, S.; Spencer, B.R., Jr.; Norris, W.
Structure/function relationships responsible for the kinetic differences between human type 1 and type 2 3beta-hydroxysteroid dehydrogenase and for the catalysis of the type 1 activity
J. Biol. Chem.
277
42795-42801
2002
Homo sapiens, Homo sapiens (P14060), Homo sapiens (P26439)
Thomas, J.L.; Duax, W.L.; Addlagatta, A.; Scaccia, L.A.; Frizzell, K.A.; Carloni, S.B.
Serine 124 completes the Tyr, Lys and Ser triad responsible for the catalysis of human type 1 3beta-hydroxysteroid dehydrogenase
J. Mol. Endocrinol.
33
253-261
2004
Homo sapiens
Ohno, S.; Matsumoto, N.; Watanabe, M.; Nakajin, S.
Flavonoid inhibition of overexpressed human 3beta-hydroxysteroid dehydrogenase type II
J. Steroid Biochem. Mol. Biol.
88
175-182
2004
Homo sapiens
Thomas, J.L.; Duax, W.L.; Addlagatta, A.; Kacsoh, B.; Brandt, S.E.; Norris, W.B.
Structure/function aspects of human 3beta-hydroxysteroid dehydrogenase
Mol. Cell. Endocrinol.
215
73-82
2004
Homo sapiens
Thomas, J.L.; Boswell, E.L.; Scaccia, L.A.; Pletnev, V.; Umland, T.C.
Identification of key amino acids responsible for the substantially higher affinities of human type 1 3beta-hydroxysteroid dehydrogenase/isomerase (3b-HSD1) for substrates, coenzymes, and inhibitors relative to human 3b-HSD2
J. Biol. Chem.
280
21321-21328
2005
Homo sapiens (P14060), Homo sapiens (P26439), Homo sapiens
Nakamura, Y.; Suzuki, T.; Inoue, T.; Tazawa, C.; Moriya, T.; Saito, H.; Ishibashi, T.; Takahashi, S.; Yamada, S.; Sasano, H.
3beta-hydroxysteroid dehydrogenase in human aorta
Endocr. J.
52
111-115
2005
Homo sapiens
Martin, L.J.; Tremblay, J.J.
The human 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4 isomerase type 2 promoter is a novel target for the immediate early orphan nuclear receptor Nur77 in steroidogenic cells
Endocrinology
146
861-869
2005
Homo sapiens
Pletnev, V.Z.; Thomas, J.L.; Rhaney, F.L.; Holt, L.S.; Scaccia, L.A.; Umland, T.C.; Duax, W.L.
Rational proteomics V: structure-based mutagenesis has revealed key residues responsible for substrate recognition and catalysis by the dehydrogenase and isomerase activities in human 3beta-hydroxysteroid dehydrogenase/isomerase type 1
J. Steroid Biochem. Mol. Biol.
101
50-60
2006
Homo sapiens (P14060), Homo sapiens
Lacey, M.; Bohday, J.; Fonseka, S.M.; Ullah, A.I.; Whitehead, S.A.
Dose-response effects of phytoestrogens on the activity and expression of 3beta-hydroxysteroid dehydrogenase and aromatase in human granulosa-luteal cells
J. Steroid Biochem. Mol. Biol.
96
279-286
2005
Homo sapiens
Matsunaga, T.; Endo, S.; Maeda, S.; Ishikura, S.; Tajima, K.; Tanaka, N.; Nakamura, K.T.; Imamura, Y.; Hara, A.
Characterization of human DHRS4: An inducible short-chain dehydrogenase/reductase enzyme with 3beta-hydroxysteroid dehydrogenase activity
Arch. Biochem. Biophys.
477
339-347
2008
Homo sapiens
Welzel, M.; Wuestemann, N.; Simic-Schleicher, G.; Doerr, H.G.; Schulze, E.; Shaikh, G.; Clayton, P.; Groetzinger, J.; Holterhus, P.M.; Riepe, F.G.
Carboxyl-terminal mutations in 3beta-hydroxysteroid dehydrogenase type II cause severe salt-wasting congenital adrenal hyperplasia
J. Clin. Endocrinol. Metab.
93
1418-1425
2008
Homo sapiens
Thomas, J.L.; Huether, R.; Mack, V.L.; Scaccia, L.A.; Stoner, R.C.; Duax, W.L.
Structure/function of human type 1 3beta-hydroxysteroid dehydrogenase: An intrasubunit disulfide bond in the Rossmann-fold domain and a Cys residue in the active site are critical for substrate and coenzyme utilization
J. Steroid Biochem. Mol. Biol.
107
80-87
2007
Homo sapiens
Wang, L.; Salavaggione, E.; Pelleymounter, L.; Eckloff, B.; Wieben, E.; Weinshilboum, R.
Human 3beta-hydroxysteroid dehydrogenase types 1 and 2: Gene sequence variation and functional genomics
J. Steroid Biochem. Mol. Biol.
107
88-99
2007
Homo sapiens
Thomas, J.L.; Mack, V.L.; Glow, J.A.; Moshkelani, D.; Terrell, J.R.; Bucholtz, K.M.
Structure/function of the inhibition of human 3beta-hydroxysteroid dehydrogenase type 1 and type 2 by trilostane
J. Steroid Biochem. Mol. Biol.
111
66-73
2008
Homo sapiens
Hu, G.X.; Zhou, H.Y.; Li, X.W.; Chen, B.B.; Xiao, Y.C.; Lian, Q.Q.; Liang, G.; Kim, H.H.; Zheng, Z.Q.; Hardy, D.O.; Ge, R.S.
The (+)- and (-)-gossypols potently inhibit both 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase 3 in human and rat testes
J. Steroid Biochem. Mol. Biol.
115
14-19
2009
Homo sapiens, Rattus norvegicus
Thomas, J.L.; Bucholtz, K.M.; Sun, J.; Mack, V.L.; Kacsoh, B.
Structural basis for the selective inhibition of human 3beta-hydroxysteroid dehydrogenase 1 in human breast tumor MCF-7 cells
Mol. Cell. Endocrinol.
301
174-182
2009
Homo sapiens
Nittono, H.; Takei, H.; Unno, A.; Shimizu, T.; Kobayashi, M.; Koike, M.; Murai, T.; Kurosawa, T.; Thoma, M.
3?-hydroxy-??-C??-steroid dehydrogenase/isomerase deficiency in a patient who underwent oral bile acid therapy for 10 years and delivered two healthy infants.
Pediatr. Internat.
52
e192-e195
2010
Homo sapiens
Rajapaksha, M.; Thomas, J.L.; Streeter, M.; Prasad, M.; Whittal, R.M.; Bell, J.D.; Bose, H.S.
Lipid-mediated unfolding of 3beta-hydroxysteroid dehydrogenase 2 is essential for steroidogenic activity
Biochemistry
50
11015-11024
2011
Homo sapiens (P26439)
Prasad, M.; Thomas, J.L.; Whittal, R.M.; Bose, H.S.
Mitochondrial 3beta-hydroxysteroid dehydrogenase enzyme activity requires reversible pH-dependent conformational change at the intermembrane space
J. Biol. Chem.
287
9534-9546
2012
Homo sapiens (P26439)
Zhao, Y.; Xiao, J.
Homology modeling and molecular dynamics simulation studies of human type 1 3beta-hydroxysteroid dehydrogenase: Toward the understanding of cofactor specificity
J. Comput. Chem.
32
33-42
2011
Homo sapiens (P14060), Homo sapiens
Thomas, J.L.; Mack, V.L.; Sun, J.; Terrell, J.R.; Bucholtz, K.M.
The functions of key residues in the inhibitor, substrate and cofactor sites of human 3beta-hydroxysteroid dehydrogenase type 1 are validated by mutagenesis
J. Steroid Biochem. Mol. Biol.
120
192-199
2010
Homo sapiens (P14060), Homo sapiens (P26439)
Nakamura, Y.; Xing, Y.; Hui, X.G.; Kurotaki, Y.; Ono, K.; Cohen, T.; Sasano, H.; Rainey, W.E.
Human adrenal cells that express both 3?-hydroxysteroid dehydrogenase type 2 (HSD3B2) and cytochrome b5 (CYB5A) contribute to adrenal androstenedione production
J. Steroid Biochem. Mol. Biol.
123
122-126
2011
Homo sapiens
Thomas, J.; Bucholtz, K.; Kacsoh, B.
Selective inhibition of human 3beta-hydroxysteroid dehydrogenase type 1 as a potential treatment for breast cancer
J. Steroid Biochem. Mol. Biol.
125
57-65
2011
Homo sapiens (P14060), Homo sapiens (P26439)
Yang, G.; Dou, J.; Zhang, X.; Gu, W.; Lv, Z.; DU, J.; Ba, J.; Mu, Y.; Lu, J.
Increased 3beta-hydroxysteroid dehydrogenase 2 and 17beta-hydroxylase activities in a virilized adolescent female with adrenal adenoma: A case report
Exp. Ther. Med.
11
530-534
2016
Homo sapiens
Thomas, J.L.; Bose, H.S.
Regulation of human 3-beta-hydroxysteroid dehydrogenase type-2 (3betaHSD2) by molecular chaperones and the mitochondrial environment affects steroidogenesis
J. Steroid Biochem. Mol. Biol.
151
74-84
2015
Homo sapiens
Ota, T.; Doi, M.; Yamazaki, F.; Yarimizu, D.; Okada, K.; Murai, I.; Hayashi, H.; Kunisue, S.; Nakagawa, Y.; Okamura, H.
Angiotensin II triggers expression of the adrenal gland zona glomerulosa-specific 3beta-hydroxysteroid dehydrogenase isoenzyme through de novo protein synthesis of the orphan nuclear receptors NGFIB and NURR1
Mol. Cell. Biol.
34
3880-3894
2014
Homo sapiens (P14060), Homo sapiens
Konosu-Fukaya, S.; Nakamura, Y.; Satoh, F.; Felizola, S.J.; Maekawa, T.; Ono, Y.; Morimoto, R.; Ise, K.; Takeda, K.; Katsu, K.; Fujishima, F.; Kasajima, A.; Watanabe, M.; Arai, Y.; Gomez-Sanchez, E.P.; Gomez-Sanchez, C.E.; Doi, M.; Okamura, H.; Sasano, H.
3beta-Hydroxysteroid dehydrogenase isoforms in human aldosterone-producing adenoma
Mol. Cell. Endocrinol.
408
205-212
2015
Homo sapiens, Homo sapiens (P26439)
Louw-du Toit, R.; Perkins, M.S.; Snoep, J.L.; Storbeck, K.H.; Africander, D.
Fourth-generation progestins inhibit 3beta-hydroxysteroid dehydrogenase type 2 and modulate the biosynthesis of endogenous steroids
PLoS ONE
11
e0164170
2016
Homo sapiens
Ando, T.; Nishiyama, T.; Takizawa, I.; Ishizaki, F.; Miyashiro, Y.; Takeda, K.; Hara, N.; Tomita, Y.
Dihydrotestosterone synthesis pathways from inactive androgen 5alpha-androstane-3beta,17beta-diol in prostate cancer cells: Inhibition of intratumoural 3beta-hydroxysteroid dehydrogenase activities by abiraterone
Sci. Rep.
6
32198
2016
Homo sapiens
Zhang, S.; Mo, J.; Wang, Y.; Ni, C.; Li, X.; Zhu, Q.; Ge, R.S.
Endocrine disruptors of inhibiting testicular 3beta-hydroxysteroid dehydrogenase
Chem. Biol. Interact.
303
90-97
2019
Homo sapiens (P26439), Homo sapiens
Kordus, R.J.; Hossain, A.; Corso, M.C.; Chakraborty, H.; Whitman-Elia, G.F.; LaVoie, H.A.
Cumulus cell pappalysin-1, luteinizing hormone/choriogonadotropin receptor, amphiregulin and hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 mRNA levels associate with oocyte developmental competence and embryo outcomes
J. Assist. Reprod. Genet.
36
1457-1469
2019
Homo sapiens (P26439), Homo sapiens
Pham, J.H.; Will, C.M.; Mack, V.L.; Halbert, M.; Conner, E.A.; Bucholtz, K.M.; Thomas, J.L.
Structure-function relationships for the selective inhibition of human 3beta-hydroxysteroid dehydrogenase type 1 by a novel androgen analog
J. Steroid Biochem. Mol. Biol.
174
257-264
2017
Homo sapiens (P14060), Homo sapiens (P26439)
