Information on EC 1.1.1.135 - GDP-6-deoxy-D-talose 4-dehydrogenase

for references in articles please use BRENDA:EC1.1.1.135
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

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EC NUMBER
COMMENTARY hide
1.1.1.135
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RECOMMENDED NAME
GeneOntology No.
GDP-6-deoxy-D-talose 4-dehydrogenase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
GDP-6-deoxy-alpha-D-talose + NAD(P)+ = GDP-4-dehydro-alpha-D-rhamnose + NAD(P)H + H+
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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-
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redox reaction
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-
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reduction
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
GDP-6-deoxy-D-talose biosynthesis
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Fructose and mannose metabolism
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Amino sugar and nucleotide sugar metabolism
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SYSTEMATIC NAME
IUBMB Comments
GDP-6-deoxy-alpha-D-talose:NAD(P)+ 4-oxidoreductase
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CAS REGISTRY NUMBER
COMMENTARY hide
37250-66-1
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
expression in Escherichia coli
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Manually annotated by BRENDA team
gram-negative motile strain GS isolated from soil
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Manually annotated by BRENDA team
enzyme is identical to 3-hydroxyacyl-CoA dehydrogenase type II
Swissprot
Manually annotated by BRENDA team
enzyme is identical to 3-hydroxyacyl-CoA dehydrogenase type II
Uniprot
Manually annotated by BRENDA team
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
GDP-4-dehydro-6-deoxy-D-talose + NAD(P)H
GDP-6-deoxy-D-talose + NAD(P)+
show the reaction diagram
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
GDP-4-dehydro-6-deoxy-D-talose + NAD(P)H
GDP-6-deoxy-D-talose + NAD(P)+
show the reaction diagram
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-
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ir
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADH
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NADPH
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-
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
cultured skin fibroblast
Manually annotated by BRENDA team
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
28000
x * 28000, SDS-PAGE
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SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 28000, SDS-PAGE
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
partial
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
L122C
missence mutation found in patient with inborn error of isoleucine degradation, almost complete loss of enzyme activity
R130C
missence mutation found in patient with inborn error of isoleucine degradation, almost complete loss of enzyme activity
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
L122C and R130C are missence mutations found in patients with inborn error of isoleucine degradation, almost complete loss of enzyme activity
synthesis
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use of enzyme for synthesis of GDP-deoxyhexoses
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LINKS TO OTHER DATABASES (specific for EC-Number 1.1.1.135)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)