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EC Tree
IUBMB Comments The enzyme from Pseudomonas acts equally well on NAD+ or NADP+, while that from Erwinia chrysanthemi and Escherichia coli is more specific for NAD+.
The enzyme appears in viruses and cellular organisms
Synonyms
2-dehydro-3-deoxy-d-gluconate 5-dehydrogenase,
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2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase
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2-keto-3-deoxy-D-gluconate (3-deoxy-D-glycero-2,5-hexodiulosonic acid) dehydrogenase
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2-keto-3-deoxy-D-gluconate dehydrogenase
2-keto-3-deoxygluconate (nicotinamide adenine dinucleotide (phosphate)) dehydrogenase
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2-keto-3-deoxygluconate 5-dehydrogenase
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2-keto-3-deoxy-D-gluconate dehydrogenase
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2-keto-3-deoxy-D-gluconate dehydrogenase
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2-dehydro-3-deoxy-D-gluconate + NAD+ = (4S)-4,6-dihydroxy-2,5-dioxohexanoate + NADH + H+
The enzyme from Pseudomas acts equally well on NAD+ or NADP+, while that from Erwinia chrysanthemi and E. coli is more specific for NAD+
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2-dehydro-3-deoxy-D-gluconate:NAD+ 5-oxidoreductase
The enzyme from Pseudomonas acts equally well on NAD+ or NADP+, while that from Erwinia chrysanthemi and Escherichia coli is more specific for NAD+.
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2,5-didehydro-3-deoxy-D-gluconate + NADH + H+
2-dehydro-3-deoxy-D-gluconate + NAD+
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2,5-didehydro-3-deoxy-D-gluconate + NADPH + H+
2-dehydro-3-deoxy-D-gluconate + NADP+
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2-dehydro-3-deoxy-D-gluconate + NAD+
(4S)-4,6-dihydroxy-2,5-dioxohexanoate + NADH
pyruvate + NAD+
? + NADH
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10% of the activity compared to 2-dehydro-3-deoxy-D-gluconate
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2-dehydro-3-deoxy-D-gluconate + NAD+
(4S)-4,6-dihydroxy-2,5-dioxohexanoate + NADH
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involved in pectinolysis by some phytopathogenic bacteria
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2-dehydro-3-deoxy-D-gluconate + NAD+
(4S)-4,6-dihydroxy-2,5-dioxohexanoate + NADH
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irreversible at pH 7.0
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ir
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2,5-didehydro-3-deoxy-D-gluconate + NADH + H+
2-dehydro-3-deoxy-D-gluconate + NAD+
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2,5-didehydro-3-deoxy-D-gluconate + NADPH + H+
2-dehydro-3-deoxy-D-gluconate + NADP+
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?
2-dehydro-3-deoxy-D-gluconate + NAD+
(4S)-4,6-dihydroxy-2,5-dioxohexanoate + NADH
2-dehydro-3-deoxy-D-gluconate + NAD+
(4S)-4,6-dihydroxy-2,5-dioxohexanoate + NADH
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involved in pectinolysis by some phytopathogenic bacteria
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r
2-dehydro-3-deoxy-D-gluconate + NAD+
(4S)-4,6-dihydroxy-2,5-dioxohexanoate + NADH
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irreversible at pH 7.0
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ir
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NAD+
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NADH
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NADH
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the enzyme utilizes both NADH and NADPH
NADP+
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NADP+
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53% lower activity than with NAD+
NADPH
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62% lower activity than with NADH
NADPH
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the enzyme utilizes both NADH and NADPH
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Ca2+
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20% activation at 1 mM
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Ag+
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72% inhibition at 0.01 mM
ATP
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30% inhibition for both reduction and oxidation reaction at 1 mM
p-chloromercuribenzoate
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50% inhibition at 0.02 mM
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0.34
(4S)-4,6-dihydroxy-2,5-dioxohexanoate
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7.7
2-dehydro-3-deoxy-D-gluconate
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0.005
NADPH
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at pH 7.2 and 45°C
0.0021
NADH
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at pH 7.2 and 45°C
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0.024
NADH
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at pH 7.2 and 45°C
0.021
NADPH
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at pH 7.2 and 45°C
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7 - 7.5
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reduction reaction
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brenda
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brenda
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brenda
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brenda
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brenda
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25000
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4 * 25000, SDS-PAGE
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homotetramer
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4 * 25000, SDS-PAGE
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in complex with NAD+, hanging drop vapor diffusion method, using 5% (w/v) polyethylene glycol 4000, and 10% (v/v) isopropanol
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the enzyme shows more than 70% activity at 40°C for 5 min
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half-life: 10 min, NADH increases thermal stability
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1 mM NAD+ or NADP+ increase stability
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-20°C, 2 mM DTT, 6 months
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0-3°C, 1 mM NAD+ or NADP+, 50-67% retaining activity after 5 weeks
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to homogeneity, 2step chromatography
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Toyopearl DEAE-650 M column chromatography, Toyopearl butyl-650 M column chromatography, Q-Sepharose column chromatography, and Superdex 200 pg gel filtration
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expressed in Escherichia coli BL21(DE3) cells
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Condemine, G.; Hugouvieux-Cotte-Pattat, N.; Robert-Baudouy, J.
An enzyme in the pectinolytic pathway of Erwinia chrysanthemi: 2-Keto-3-deoxygluconate oxidoreductase
J. Gen. Microbiol.
130
2839-2844
1984
Dickeya chrysanthemi
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brenda
Preiss, J.; Ashwell, G.
Polygalacturonic acid metabolism in bacteria. II. Formation and metabolism of 3-deoxy-D-glycero-2,5-hexodiulosonic acid
J. Biol. Chem.
238
1577-1583
1963
Pseudomonas sp.
brenda
Takase, R.; Maruyama, Y.; Oiki, S.; Mikami, B.; Murata, K.; Hashimoto, W.
Structural determinants in bacterial 2-keto-3-deoxy-D-gluconate dehydrogenase KduD for dual-coenzyme specificity
Proteins
84
934-947
2016
Pectobacterium carotovorum subsp. carotovorum
brenda
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