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The enzyme appears in viruses and cellular organisms
Synonyms
ddgdh, 2-keto-3-deoxy-d-gluconate dehydrogenase, more
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2-keto-3-deoxy-D-gluconate dehydrogenase
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2-keto-3-deoxygluconate dehydrogenase
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ketodeoxygluconate dehydrogenase
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NAD-dependent 3-dehydro-2-deoxy-D-gluconate dehydrogenase
DDGDH
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NAD-dependent 3-dehydro-2-deoxy-D-gluconate dehydrogenase
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NAD-dependent 3-dehydro-2-deoxy-D-gluconate dehydrogenase
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2-dehydro-3-deoxy-D-gluconate + NADP+ = (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + NADPH + H+
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MetaCyc
alginate degradation
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2-dehydro-3-deoxy-D-gluconate:NADP+ 6-oxidoreductase
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(4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + NADPH
2-dehydro-3-deoxy-D-gluconate + NADP+
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Substrates: irreversible at pH 7.0, 1% reversibility at pH 10.0
Products: -
ir
2-dehydro-3-deoxy-D-gluconate + NAD+
(4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + NADH + H+
2-dehydro-3-deoxy-D-gluconate + NAD+
(4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + NADH + H+
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Substrates: -
Products: -
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2-dehydro-3-deoxy-D-gluconate + NAD+
(4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + NADH + H+
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Substrates: -
Products: -
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(4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + NADPH
2-dehydro-3-deoxy-D-gluconate + NADP+
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Substrates: irreversible at pH 7.0, 1% reversibility at pH 10.0
Products: -
ir
2-dehydro-3-deoxy-D-gluconate + NAD+
(4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + NADH + H+
2-dehydro-3-deoxy-D-gluconate + NAD+
(4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + NADH + H+
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Substrates: -
Products: -
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2-dehydro-3-deoxy-D-gluconate + NAD+
(4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + NADH + H+
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Substrates: -
Products: -
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NAD+
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this enzyme prefers NAD+ as the physiological cofactor
NADH
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7.2% of the rate compared to NADPH
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p-hydroxymercuribenzoate
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26% inhibition at 0.1 mM
Tris-HCl
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67% inhibition at pH 7.5, 50 mM
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0.36
(4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate
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alginate-adapted
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brenda
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brenda
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brenda
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inducible enzyme synthesis by growth in alginate-containing medium
brenda
Highest Expressing Human Cell Lines
Cell Line Links
Gene Links
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D6RU56_9SPHN
258
0
26948
TrEMBL
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homotetramer
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X-ay crystallography
homotetramer
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X-ay crystallography
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in complex with NAD+, sitting drop vapor diffusion method, using 0.1 M bicine pH 9.0, 2% (w/v) dioxane, 10% (w/v) PEG 20 000
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unstable in the absence of NADP+
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0-3°C, 1 mM NADP+, 90% retaining activity after 3 weeks
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Super Q Toyopearl 650M column chromatography, Resource Q column chromatography, Bio-Scale CHT20-I column chromatography, and Superdex 75 gel filtration
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to homogeneity, chromatography techniques
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Preiss, J.; Ashwell, G.
Alginic acid metabolism in bacteria. II. The enzymatic reduction of 4-deoxy-L-erythro-5-hexoseulose uronic acid to 2-keto-3-deoxy-D-gluconic acid
J. Biol. Chem.
237
317-321
1962
Pseudomonas sp.
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Pampa, K.J.; Lokanath, N.K.; Kunishima, N.; Rai, R.V.
The first crystal structure of NAD-dependent 3-dehydro-2-deoxy-D-gluconate dehydrogenase from Thermus thermophilus HB8
Acta Crystallogr. Sect. D
70
994-1004
2014
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
brenda
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