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Information on EC 1.1.1.117 - D-arabinose 1-dehydrogenase [NAD(P)+]
for references in articles please use BRENDA:EC1.1.1.117
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EC Tree 1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.117 D-arabinose 1-dehydrogenase [NAD(P)+]
IUBMB Comments
Also acts on L-galactose, 6-deoxy- and 3,6-dideoxy-L-galactose.
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
showSynonyms
ARA1, D-arabinose dehydrogenase, dehydrogenase, D-arabinose (nicotinamide adenine dinucleotide (phosphate)), more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
dehydrogenase, D-arabinose (nicotinamide adenine dinucleotide (phosphate))
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
D-arabinose + NAD(P)+ = D-arabinono-1,4-lactone + NAD(P)H + H+
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-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
D-arabinose:NAD(P)+ 1-oxidoreductase
Also acts on L-galactose, 6-deoxy- and 3,6-dideoxy-L-galactose.
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CAS REGISTRY NUMBER
COMMENTARY
37250-48-9
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
D-arabinose + NAD+
D-arabinono-1,4-lactone + NADH + H+
-
Substrates: -
Products: -
Products: -
r
D-arabinose + NADP+
D-arabinono-1,4-lactone + NADPH + H+
Substrates: -
Products: -
Products: -
?
L-colitose + NAD(P)+
3,6-dideoxy-L-galactono-1,5-lactone + NAD(P)H
-
Substrates: i.e. 3,6-dideoxy-L-galactose
Products: -
Products: -
?
D-arabinose + NAD(P)+
D-arabino-1,4-lactone + NAD(P)H
-
Substrates: -
Products: -
Products: -
?
D-arabinose + NAD(P)+
D-arabino-1,4-lactone + NAD(P)H
-
Substrates: -
Products: -
Products: -
?
D-arabinose + NAD(P)+
D-arabino-1,4-lactone + NAD(P)H
-
Substrates: alpha-anomer preferred
Products: -
Products: -
?
D-arabinose + NAD(P)+
D-arabino-1,4-lactone + NAD(P)H
-
Substrates: specific for sugars of the optical configuration of L-galactose
Products: -
Products: -
?
D-arabinose + NAD(P)+
D-arabino-1,4-lactone + NAD(P)H
-
Substrates: -
Products: -
Products: -
?
D-arabinose + NAD(P)+
D-arabino-1,4-lactone + NAD(P)H
-
Substrates: -
Products: -
Products: -
?
L-fucose + NADP+
6-deoxy-L-galactono-1,4-lactone + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
L-fucose + NADP+
6-deoxy-L-galactono-1,4-lactone + NADPH + H+
-
Substrates: i.e. 6-deoxy-L-galactose
Products: -
Products: -
?
L-galactose + NADP+
L-galactono-1,4-lactone + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
L-galactose + NADP+
L-galactono-1,4-lactone + NADPH + H+
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Substrates: beta-anomer preferred
Products: -
Products: -
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
D-arabinose + NADP+
D-arabinono-1,4-lactone + NADPH + H+
Substrates: -
Products: -
Products: -
?
D-arabinose + NAD(P)+
D-arabino-1,4-lactone + NAD(P)H
-
Substrates: -
Products: -
Products: -
?
D-arabinose + NAD(P)+
D-arabino-1,4-lactone + NAD(P)H
-
Substrates: -
Products: -
Products: -
?
D-arabinose + NAD(P)+
D-arabino-1,4-lactone + NAD(P)H
-
Substrates: specific for sugars of the optical configuration of L-galactose
Products: -
Products: -
?
D-arabinose + NAD(P)+
D-arabino-1,4-lactone + NAD(P)H
-
Substrates: -
Products: -
Products: -
?
D-arabinose + NAD(P)+
D-arabino-1,4-lactone + NAD(P)H
-
Substrates: -
Products: -
Products: -
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
Highest Expressing Human Cell Lines
Cell Line LinksPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
-
a double mutant DELATbdh1 and DELTA ara1 strain still produces (2S,3S)-2,3-butanediol and meso-2,3-butanediol suggesting only a minor role of Ara1p in the production of 2,3-butanediol
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). ARA1_YEAST
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
344
0
38884
Swiss-Prot
other Location (Reliability: 1)
A0A1S7UL89_ROSNE
330
0
37048
TrEMBL
other Location (Reliability: 2)
W1Q7N1_OGAPD
Ogataea parapolymorpha (strain ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1)
311
0
35433
TrEMBL
other Location (Reliability: 1)
A0A084FV16_PSEDA
325
0
36940
TrEMBL
other Location (Reliability: 3)
A0A0B2PE94_GLYSO
70
0
7584
TrEMBL
other Location (Reliability: 2)
A0A8J5BDP7_9ASCO
313
0
34835
TrEMBL
other Location (Reliability: 2)
B9WC89_CANDC
Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841)
326
0
37361
TrEMBL
other Location (Reliability: 1)
Q97YM2_SACS2
Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
349
0
37879
TrEMBL
-
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PDB
SCOP
CATH
UNIPROT
ORGANISM
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
20000
-
x * 20000, sedimentation analysis in 4.2 M guanidinium chloride, presence of subunits of unequal size might be possible
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
?
-
x * 20000, sedimentation analysis in 4.2 M guanidinium chloride, presence of subunits of unequal size might be possible
?
-
x * 20000, sedimentation analysis in 4.2 M guanidinium chloride, presence of subunits of unequal size might be possible
-
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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
apo and NADPH-complexed enzyme forms, hanging drop vapor diffusion method, using 25% (w/v) polyethylene glycol 3350, 0.1 M HEPES pH 7.5
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
58
-
half-life of 20 s is increased to 80 s in presence of cofactor, in both cases biphasic inactivation curve
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, acetone-dried cells retain full activity for extended periods of time
-
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kim, S.T.; Huh, W.K.; Kim, J.Y.; Hwang, S.W.; Kang, S.O.
D-Arabinose dehydrogenase and biosynthesis of erythroascorbic acid in Candida albicans
Biochim. Biophys. Acta
1297
1-8
1996
Candida albicans
brenda
Cline, A.L.; Hu, A.S.L.
The isolation of three sugar dehydrogenases from a pseudomonad
J. Biol. Chem.
240
4488-4492
1965
Pseudomonas sp., Pseudomonas sp. G6
brenda
Cline, A.L.; Hu, A.S.L.
Enzymatic characterization and comparison of three sugar dehydrogenases from a pseudomonad
J. Biol. Chem.
240
4493-4497
1965
Pseudomonas sp., Pseudomonas sp. G6
brenda
Cline, A.L.; Hu, A.S.L.
Some physical properties of three sugar dehydrogenases from a pseudomonad
J. Biol. Chem.
240
4498-4502
1965
Pseudomonas sp., Pseudomonas sp. G6
brenda
Metzger, R.P.; Wick, A.N.
Partial purification of rat liver D-arabinose dehydrogenase
Biochem. Biophys. Res. Commun.
26
742-747
1967
Rattus norvegicus
brenda
Hu, X.Q.; Guo, P.C.; Ma, J.D.; Li, W.F.
Structures of Saccharomyces cerevisiae D-arabinose dehydrogenase Ara1 and its complex with NADPH: implications for cofactor-assisted substrate recognition
Acta Crystallogr. Sect. F
69
1190-1195
2013
Saccharomyces cerevisiae (P38115)
brenda
EXTERNAL LINKS (specific for EC-Number 1.1.1.117)
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