Information on EC 1.1.1.111 - 3-(imidazol-5-yl)lactate dehydrogenase

for references in articles please use BRENDA:EC1.1.1.111
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The expected taxonomic range for this enzyme is: Delftia acidovorans

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EC NUMBER
COMMENTARY hide
1.1.1.111
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RECOMMENDED NAME
GeneOntology No.
3-(imidazol-5-yl)lactate dehydrogenase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(S)-3-(imidazol-5-yl)lactate + NAD(P)+ = 3-(imidazol-5-yl)pyruvate + NAD(P)H + H+
show the reaction diagram
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-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
imidazole-lactate degradation
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-
L-histidine degradation IV
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histidine metabolism
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-
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SYSTEMATIC NAME
IUBMB Comments
(S)-3-(imidazol-5-yl)lactate:NAD(P)+ oxidoreductase
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CAS REGISTRY NUMBER
COMMENTARY hide
37250-42-3
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(S)-3-(imidazol-5-yl)lactate + NAD(P)+
3-(imidazol-5-yl)pyruvate + NAD(P)H
show the reaction diagram
-
imidazoyl-lactate formation is favoured
-
r
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(S)-3-(imidazol-5-yl)lactate + NAD(P)+
3-(imidazol-5-yl)pyruvate + NAD(P)H
show the reaction diagram
-
imidazoyl-lactate formation is favoured
-
r
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NAD(P)+
-
58% enzyme activity with NADH compared to NADPH
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7
-
in crude extracts, cofactor NADH
12
-
in crude extracts, cofactor NADPH
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LINKS TO OTHER DATABASES (specific for EC-Number 1.1.1.111)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)