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EC 5.4.99.12 Details
EC number
5.4.99.12
Accepted name
tRNA pseudouridine38-40 synthase
Reaction
tRNA uridine38-40 = tRNA pseudouridine38-40
Other name(s)
TruA, tRNA pseudouridine synthase I, PSUI, hisT (gene name)
Systematic name
tRNA-uridine38-40 uracil mutase
CAS registry number
61506-89-6
Comment
The uridylate residues at positions 38, 39 and 40 of nearly all tRNAs are isomerized to pseudouridine. TruA specifically modifies uridines at positions 38, 39, and/or 40 in the anticodon stem loop of tRNAs with highly divergent sequences and structures [1].
History
created 1990, modified 2011
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EC Tree
1 Oxidoreductases
2 Transferases
3 Hydrolases
4 Lyases
5 Isomerases
5.1 Racemases and epimerases
5.2 cis-trans-Isomerases
5.3 Intramolecular oxidoreductases
5.4 Intramolecular transferases
5.4.1 Transferring acyl groups
5.4.2 Phosphotransferases (phosphomutases)
5.4.3 Transferring amino groups
5.4.4 Transferring hydroxy groups
5.4.99 Transferring other groups
5.4.99.1 methylaspartate mutase
5.4.99.2 methylmalonyl-CoA mutase
5.4.99.3 2-acetolactate mutase
5.4.99.4 2-methyleneglutarate mutase
5.4.99.5 chorismate mutase
5.4.99.6 created 1972, deleted 2003
5.4.99.7 lanosterol synthase
5.4.99.8 cycloartenol synthase
5.4.99.9 UDP-galactopyranose mutase
5.4.99.10 created 1984, deleted 1992
5.4.99.11 isomaltulose synthase
5.4.99.12 tRNA pseudouridine38-40 synthase
5.4.99.13 isobutyryl-CoA mutase
5.4.99.14 4-carboxymethyl-4-methylbutenolide mutase
5.4.99.15 (1→4)-α-D-glucan 1-α-D-glucosylmutase
5.4.99.16 maltose α-D-glucosyltransferase
5.4.99.17 squalene—hopene cyclase
5.4.99.18 5-(carboxyamino)imidazole ribonucleotide mutase
5.4.99.19 16S rRNA pseudouridine516 synthase
5.4.99.20 23S rRNA pseudouridine2457 synthase
5.4.99.21 23S rRNA pseudouridine2604 synthase
5.4.99.22 23S rRNA pseudouridine2605 synthase
5.4.99.23 23S rRNA pseudouridine1911/1915/1917 synthase
5.4.99.24 23S rRNA pseudouridine955/2504/2580 synthase
5.4.99.25 tRNA pseudouridine55 synthase
5.4.99.26 tRNA pseudouridine65 synthase
5.4.99.27 tRNA pseudouridine13 synthase
5.4.99.28 tRNA pseudouridine32 synthase
5.4.99.29 23S rRNA pseudouridine746 synthase
5.4.99.30 UDP-arabinopyranose mutase
5.4.99.31 thalianol synthase
5.4.99.32 protostadienol synthase
5.4.99.33 cucurbitadienol synthase
5.4.99.34 germanicol synthase
5.4.99.35 taraxerol synthase
5.4.99.36 isomultiflorenol synthase
5.4.99.37 dammaradiene synthase
5.4.99.38 camelliol C synthase
5.4.99.39 β-amyrin synthase
5.4.99.40 α-amyrin synthase
5.4.99.41 lupeol synthase
5.4.99.42 tRNA pseudouridine31 synthase
5.4.99.43 21S rRNA pseudouridine2819 synthase
5.4.99.44 mitochondrial tRNA pseudouridine27/28 synthase
5.4.99.45 tRNA pseudouridine38/39 synthase
5.4.99.46 shionone synthase
5.4.99.47 parkeol synthase
5.4.99.48 achilleol B synthase
5.4.99.49 glutinol synthase
5.4.99.50 friedelin synthase
5.4.99.51 baccharis oxide synthase
5.4.99.52 α-seco-amyrin synthase
5.4.99.53 marneral synthase
5.4.99.54 β-seco-amyrin synthase
5.4.99.55 δ-amyrin synthase
5.4.99.56 tirucalladienol synthase
5.4.99.57 baruol synthase
5.4.99.58 methylornithine synthase
5.4.99.59 dTDP-fucopyranose mutase
5.4.99.60 cobalt-precorrin-8 methylmutase
5.4.99.61 precorrin-8X methylmutase
5.4.99.62 D-ribose pyranase
5.4.99.63 ethylmalonyl-CoA mutase
5.4.99.64 2-hydroxyisobutanoyl-CoA mutase
5.4.99.65 pre-α-onocerin synthase
5.4.99.66 α-onocerin synthase
5.4.99.67 4-amino-4-deoxychorismate mutase
5.5 Intramolecular lyases
5.6 Isomerases altering macromolecular conformation
5.99 Other isomerases
6 Ligases
7 Translocases