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EC 4.3.1.17 Details
EC number
4.3.1.17
Accepted name
L-serine ammonia-lyase
Reaction
L-serine = pyruvate + NH3 (overall reaction);;(1a) L-serine = 2-aminoprop-2-enoate + H2O;;(1b) 2-aminoprop-2-enoate = 2-iminopropanoate (spontaneous);;(1c) 2-iminopropanoate + H2O = pyruvate + NH3 (spontaneous)
Other name(s)
serine deaminase, L-hydroxyaminoacid dehydratase, L-serine deaminase, L-serine dehydratase, L-serine hydro-lyase (deaminating)
Systematic name
L-serine ammonia-lyase (pyruvate-forming)
CAS registry number
9014-27-1
Comment
Most enzymes that catalyse this reaction are pyridoxal-phosphate-dependent, although some enzymes contain an iron-sulfur cluster instead [6]. The reaction catalysed by both types of enzymes involves the initial elimination of water to form an enamine intermediate (hence the enzyme’s original classification as EC 4.2.1.13, L-serine dehydratase), followed by tautomerization to an imine form and hydrolysis of the C-N bond. The latter reaction, which can occur spontaneously, is also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. This reaction is also carried out by EC 4.3.1.19, threonine ammonia-lyase, from a number of sources.
History
created 1961 as EC 4.2.1.13, transferred 2001 to EC 4.3.1.17, modified 2014
EC Tree
4.3.1.8 created 1972, modified 1982, modified 1989, deleted 2003
4.3.1.21 created 1965 as EC 4.2.1.26, transferred 2002 to EC 4.3.1.21, deleted 2004