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EC 3.2.2.9 Details
EC number
3.2.2.9
Accepted name
adenosylhomocysteine nucleosidase
Reaction
(1) S-adenosyl-L-homocysteine + H2O = S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine;;(2) 5′-deoxyadenosine + H2O = 5-deoxy-D-ribose + adenine;;(3) S-methyl-5′-thioadenosine + H2O = 5-(methylsulfanyl)-D-ribose + adenine
Other name(s)
S-adenosylhomocysteine hydrolase (ambiguous), S-adenosylhomocysteine nucleosidase, 5′-methyladenosine nucleosidase, S-adenosylhomocysteine/5′-methylthioadenosine nucleosidase, AdoHcy/MTA nucleosidase, MTN2 (gene name), mtnN (gene name)
Systematic name
S-adenosyl-L-homocysteine homocysteinylribohydrolase
CAS registry number
9055-10-1
Comment
This enzyme, found in bacteria and plants, acts on three different substrates. It is involved in the S-adenosyl-L-methionine (SAM, AdoMet) cycle, which recycles S-adenosyl-L-homocysteine back to SAM, and in salvage pathways for 5′-deoxyadenosine and S-methyl-5′-thioadenosine, which are produced from SAM during the action of many enzymes. cf. the plant enzyme EC 3.2.2.16, methylthioadenosine nucleosidase.
History
created 1972, modified 2004, modified 2020
EC Tree
3.2.2.18 created 1984, deleted 1989