EC Explorer

2.1.2.2

phosphoribosylglycinamide formyltransferase 1

10-formyltetrahydrofolate + N¹-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N²-formyl-N¹-(5-phospho-D-ribosyl)glycinamide

2-amino-N-ribosylacetamide 5′-phosphate transformylase, GAR formyltransferase, GAR transformylase, glycinamide ribonucleotide transformylase, GAR TFase, 5,10-methenyltetrahydrofolate:2-amino-N-ribosylacetamide ribonucleotide transformylase, purN (gene name), ADE8 (gene name), GART (gene name), 5′-phosphoribosylglycinamide transformylase, phosphoribosylglycinamide formyltransferase (ambiguous)

10-formyltetrahydrofolate:5′-phosphoribosylglycinamide N-formyltransferase

9032-02-4

Two enzymes are known to catalyse the third step in de novo purine biosynthesis. This enzyme utilizes 10-formyltetrahydrofolate as the formyl donor, while the other enzyme, EC 6.3.1.21, phosphoribosylglycinamide formyltransferase 2, utilizes formate. In vertebrates this activity is catalysed by a trifunctional enzyme that also catalyses the activities of EC 6.3.4.13, phosphoribosylamine—glycine ligase and EC 6.3.3.1, phosphoribosylformylglycinamidine cyclo-ligase.

created 1961, modified 2000, modified 2021