EC 1.1.5.13: (S)-2-hydroxyglutarate dehydrogenase

This is an abbreviated version!
For detailed information about (S)-2-hydroxyglutarate dehydrogenase, go to the full flat file.

Reaction

Synonyms

L-2-HG dehydrogenase, L-2-hydroxyglutarate dehydrogenase, L-2-hydroxyglutarate oxygenase, L-2HG dehydrogenase, L-2HGDH, L2HG dehydrogenase, L2HG:quinone oxidoreductase, L2HGDH, lhgO, YgaF

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.5 With a quinone or similar compound as acceptor

                1.1.5.13 (S)-2-hydroxyglutarate dehydrogenase

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All data fields related to EC 1.1.5.13

Results	in table
889	AA Sequence
1	Application
3	Cloned(Commentary)
8	Cofactor
3	General Information
3	Inhibitors
4	KM Value [mM]
4	Localization
6	Natural Substrates/ Products (Substrates)
6	Organism
4	Pathway
1	pH Optimum
1	pH Range
6	Protein Variants
4	Purification (Commentary)
1	Reaction
6	Reference
13	Source Tissue
1	Specific Activity [micromol/min/mg]
13	Substrates and Products (Substrate)
3	Subunits
21	Synonyms
1	Systematic Name
2	Turnover Number [1/s]

Substrates Products

Substrates Products on EC 1.1.5.13 - (S)-2-hydroxyglutarate dehydrogenase

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SUBSTRATE

PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

LITERATURE

COMMENTARY

Reversibility
r=reversible
ir=irreversible
?=not specified

D-2-hydroxyglutarate + 2,6-dichlorophenolindophenol

2-oxoglutarate + reduced 2,6-dichlorophenolindophenol

Arabidopsis thaliana

-

741137

Substrates: 3.7% activity compared to L-2-hydroxyglutarate
Products: -

?

L-2-hydroxyglutarate + 2,6-dichlorophenolindophenol

2-oxoglutarate + reduced 2,6-dichlorophenolindophenol

Arabidopsis thaliana

-

741137

Substrates: -
Products: -

?

L-2-hydroxyglutarate + a quinone

2-oxoglutarate + a quinol

3 entries

L-2-hydroxyglutarate + iodonitrotetrazolium

2-oxoglutarate + reduced iodonitrotetrazolium

Homo sapiens

-

657168

Substrates: -
Products: -

?

L-2-hydroxyglutarate + menaquinone-4

2-oxoglutarate + menaquinol-4

Escherichia coli

-

754854

Substrates: -
Products: -

?

L-2-hydroxyglutarate + O2

2-oxoglutarate + H2O2

Escherichia coli

-

754007

Substrates: -
Products: -

?

L-2-hydroxyglutarate + ubiquinone-1

2-oxoglutarate + ubiquinol-1

Escherichia coli

-

754854

Substrates: -
Products: -

?

additional information

?

-

2 entries

L-2-hydroxyglutarate + a quinone

2-oxoglutarate + a quinol

Arabidopsis thaliana

-

741137

Substrates: -
Products: -

?

L-2-hydroxyglutarate + a quinone

2-oxoglutarate + a quinol

Escherichia coli

-

754854

Substrates: -
Products: -

?

L-2-hydroxyglutarate + a quinone

2-oxoglutarate + a quinol

Homo sapiens

-

678483, 753297, 657168

Substrates: -
Products: -

?

additional information

?

-

Arabidopsis thaliana

-

741137

Substrates: the enzyme is not active in the presence of NAD+, NADP+, cytochrome c or O2. No activity with glycolate, L-lactate or D-lactate
Products: -

?

additional information

?

-

Escherichia coli

-

754007

Substrates: no activity with dimethylglycine, sarcosine, butyraldehyde or 3-hydroxybutyric acid. Most 2-hydroxy acids are ineffective as substrates, including L-malic acid, DL-malic acid, DL-lactic acid, L-mandelic acid, D-mandelic acid, and 2-hydroxycaproic acid
Products: -

?