Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

EC 1.1.5.12: D-lactate dehydrogenase (quinone)

This is an abbreviated version!
For detailed information about D-lactate dehydrogenase (quinone), go to the full flat file.

Reaction

Show molfile
(R)-lactate
+
Show molfile
a quinone
=
Show molfile
pyruvate
 +
Show molfile
a quinol

Synonyms

Cg1027, D-iLDH, DLD, Dld2, pp4737, quinone-dependent D-lactate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.5 With a quinone or similar compound as acceptor
                EC 1.1.5.121.1.5.12 D-lactate dehydrogenase (quinone)

Inhibitors

Inhibitors on EC 1.1.5.12 - D-lactate dehydrogenase (quinone)

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-hydroxy-3-butynoic acid
-
inactivation
Cd2+
complete inhibition
Co2+
complete inhibition
Cu2+
complete inhibition
cyanide
-
stimulates D-lactate dehydrogenase activity at neutral pH, though it inhibits the activity at alkaline pH. At 1.5 mM, 50% inhibition at pH 9.3
EDTA
partial inhibition
Fe2+
complete inhibition
Mn2+
complete inhibition
Zn2+
complete inhibition
additional information
-
not inhibited by 4-chloromercuribenzoate, N-ethylmaleimide, or 5,5'-dithiobis(2-nitrobenzoic acid)
-