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EC 1.1.5.12: D-lactate dehydrogenase (quinone)

This is an abbreviated version!
For detailed information about D-lactate dehydrogenase (quinone), go to the full flat file.

Reaction

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(R)-lactate
+
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a quinone
=
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pyruvate
 +
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a quinol

Synonyms

Cg1027, D-iLDH, DLD, Dld2, pp4737, quinone-dependent D-lactate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.5 With a quinone or similar compound as acceptor
                EC 1.1.5.121.1.5.12 D-lactate dehydrogenase (quinone)

Engineering

Engineering on EC 1.1.5.12 - D-lactate dehydrogenase (quinone)

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
F12W
-
increase in activtiy
F176W
-
about 25% of wild-type vmax
F263W
-
loss of activity
F279W
-
loss of activity
F326W
-
loss of activity
F340W
-
about 35% of wild-type vmax
F361W
-
activity similar to wild-type
F39W
-
about 50% of wild-type vmax
F412W
-
loss of activity
F435W
-
about 25% of wild-type vmax
F490W
-
loss of activity
F544W
-
loss of activity
I152W
-
loss of activity
I193W
-
loss of activity
I99W
-
loss of activity
L110W
-
loss of activity
L203W
-
loss of activity
L456W
-
loss of activity
L517W
-
about 50% of wild-type vmax
Y243W
-
activity similar to wild-type
Y309W
-
loss of activity
Y388W
-
about 75% of wild-type vmax