EC 1.1.1.441: polyprenol dehydrogenase [NAD(P)H]
This is an abbreviated version!
For detailed information about polyprenol dehydrogenase [NAD(P)H], go to the full flat file.
Reaction
Synonyms
chDHRSX, DHRSX, dolichal reductase
ECTree
1.1.1.441 polyprenol dehydrogenase [NAD(P)H]Advanced search results
results (
results (| Results | in table |
|---|---|
| 576 | AA Sequence |
| 2 | Cloned(Commentary) |
| 4 | Cofactor |
| 3 | General Information |
| 2 | Inhibitors |
| 12 | KM Value [mM] |
| 1 | Localization |
| 6 | Natural Substrates/ Products (Substrates) |
| 2 | Organism |
| 2 | Purification (Commentary) |
| 2 | Reaction |
| 2 | Reference |
| 2 | Source Tissue |
| 18 | Substrates and Products (Substrate) |
| 4 | Synonyms |
| 1 | Systematic Name |
| 12 | Turnover Number [1/s] |
General Information
General Information on EC 1.1.1.441 - polyprenol dehydrogenase [NAD(P)H]
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GENERAL INFORMATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
malfunction
physiological function
the enzyme catalyzes two nonconsecutive steps in dolichol synthesis pathway using different cofactor. The enzyme catalyses the oxidation of of polyprenol using NAD+ as the electron acceptor, and the reduction of dolichal using NADPH as the electron donors
malfunction
-
absence of the dolichol synthesis gene DHRSX leads to N-glycosylation defects in Lec5 and Lec9 Chinese hamster ovary cells
malfunction
DHRSX deficiency leads to defective N-glycosylation by disrupting dolichol synthesis. Patients with missense variants in DHRSX (DHRSX-CDG) show a pseudoautosomal-recessive disease presenting as a congenital disorder of glycosylation
