EC 1.1.1.441: polyprenol dehydrogenase [NAD(P)H]

This is an abbreviated version!
For detailed information about polyprenol dehydrogenase [NAD(P)H], go to the full flat file.

Reaction

Show molfile — a ditrans,polycis-polyprenol

Synonyms

chDHRSX, DHRSX, dolichal reductase

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.441 polyprenol dehydrogenase [NAD(P)H]

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All data fields related to EC 1.1.1.441
Results	in table
576	AA Sequence
2	Cloned(Commentary)
4	Cofactor
3	General Information
2	Inhibitors
12	KM Value [mM]
1	Localization
6	Natural Substrates/ Products (Substrates)
2	Organism
2	Purification (Commentary)
2	Reaction
2	Reference
2	Source Tissue
18	Substrates and Products (Substrate)
4	Synonyms
1	Systematic Name
12	Turnover Number [1/s]

Cofactor

Cofactor on EC 1.1.1.441 - polyprenol dehydrogenase [NAD(P)H]

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NAD+

Homo sapiens

Q8N5I4

the enzyme works equally well with NAD+ and NADP+, but due to the cellular ratios of NAD+/NADH and NADP+/NADPH, the enzyme catalyses the oxidation of of polyprenol using NAD+ as the electron acceptor, and the reduction of dolichal using NADPH as the electron donor

NADH

NADP+

NADPH