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EC 1.1.1.413: A-factor type gamma-butyrolactone 1'-reductase (1S-forming)

This is an abbreviated version!
For detailed information about A-factor type gamma-butyrolactone 1'-reductase (1S-forming), go to the full flat file.

Reaction

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a (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one
+
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NADP+
=
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a (3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one
+
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NADPH
+
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H+

Synonyms

BARS1, Virginiae butanolide-specific dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                EC 1.1.1.4131.1.1.413 A-factor type gamma-butyrolactone 1'-reductase (1S-forming)

Substrates Products

Substrates Products on EC 1.1.1.413 - A-factor type gamma-butyrolactone 1'-reductase (1S-forming)

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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY hide
Reversibility
r=reversible
ir=irreversible
?=not specified
3-heptanoyl-4-(hydroxymethyl)oxolan-2-one + NADPH + H+
?
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3-hexanoyl-4-(hydroxymethyl)oxolan-2-one + NADPH + H+
?
show the reaction diagram
4-(hydroxymethyl)-3-(6-methylheptanoyl)oxolan-2-one + NADPH + H+
?
show the reaction diagram
-
Substrates: 83.3% activity compared to 6-dehydro-Virginiae butanolide-A
Products: -
?
4-(hydroxymethyl)-3-nonanoyloxolan-2-one + NADPH + H+
?
show the reaction diagram
-
Substrates: 75.3% activity compared to 6-dehydro-Virginiae butanolide-A
Products: -
?
4-(hydroxymethyl)-3-octanoyloxolan-2-one + NADPH + H+
?
show the reaction diagram
-
Substrates: 82.8% activity compared to 6-dehydro-Virginiae butanolide-A
Products: -
?
4-(hydroxymethyl)-3-pentanoyloxolan-2-one + NADPH + H+
?
show the reaction diagram
6-dehydro-Virginiae butanolide-A + NADPH + H+
(2R,3R,6S)-Virginiae butanolide-A + NADP+
show the reaction diagram