EC 1.1.1.381: 3-hydroxy acid dehydrogenase

This is an abbreviated version!
For detailed information about 3-hydroxy acid dehydrogenase, go to the full flat file.

Reaction

Synonyms

ydfG, YMR226c

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.381 3-hydroxy acid dehydrogenase

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All data fields related to EC 1.1.1.381

Results	in table
2602	AA Sequence
2	Cloned(Commentary)
2	Cofactor
15	kcat/KM [mM/s]
16	KM Value [mM]
3	Organism
2	Pathway
2	pH Optimum
2	pH Stability
2	Purification (Commentary)
3	Reaction
3	Reference
2	Specific Activity [micromol/min/mg]
20	Substrates and Products (Substrate)
4	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
2	Temperature Stability [°C]
15	Turnover Number [1/s]

Systematic Name

Systematic Name on EC 1.1.1.381 - 3-hydroxy acid dehydrogenase

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SYSTEMATIC NAME

IUBMB Comments

L-allo-threonine:NADP+ 3-oxidoreductase

The enzyme, purified from the bacterium Escherichia coli and the yeast Saccharomyces cerevisiae, shows activity with a range of 3- and 4-carbon 3-hydroxy acids. The highest activity is seen with L-allo-threonine and D-threonine. The enzyme from Escherichia coli also shows high activity with L-serine, D-serine, (S)-3-hydroxy-2-methylpropanoate and (R)-3-hydroxy-2-methylpropanoate. The enzyme has no activity with NAD+ or L-threonine (cf. EC 1.1.1.103, L-threonine 3-dehydrogenase).