EC 1.1.1.368: 6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase

This is an abbreviated version!
For detailed information about 6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase, go to the full flat file.

Reaction

Synonyms

HAD, ThaADH

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.368 6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase

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All data fields related to EC 1.1.1.368

Results	in table
1	AA Sequence
2	Cloned(Commentary)
2	Cofactor
2	Expression
3	General Information
1	Inhibitors
1	KM Value [mM]
2	Metals/Ions
2	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
2	Organism
6	Pathway
4	PDB ID
3	pH Optimum
1	pH Range
2	Purification (Commentary)
1	Reaction
2	Reference
1	Source Tissue
1	Specific Activity [micromol/min/mg]
6	Substrates and Products (Substrate)
2	Subunits
2	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Turnover Number [1/s]

Substrates Products

Substrates Products on EC 1.1.1.368 - 6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase

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SUBSTRATE

PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

LITERATURE

COMMENTARY

Reversibility
r=reversible
ir=irreversible
?=not specified

1,2-cyclohexanedione + NADH + H+

? + NAD+

Thauera aromatica

-

741556

Substrates: -
Products: -

?

1,3-cyclopentanedione + NADH + H+

? + NAD+

Thauera aromatica

-

741556

Substrates: -
Products: -

?

6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD+

6-oxocyclohex-1-ene-1-carbonyl-CoA + NADH + H+

3 entries

additional information

?

-

Thauera aromatica

-

741556

Substrates: the enzyme exhibits a substrate specificity with highest activities on cyclic alpha- and beta-diketones including 1,2-cyclohexanedione and 1,3-cyclopentanedione, enzyme activity with 1,2-cyclohexanedione, 1,3-cyclohexanedione, and 1,3-cyclopentanedione as well as with 2,3/pentanedione, ethyl pyruvate, and cyclohexanone, but ThaADH converts neither acetophenone nor benzaldehyde which are both preferred substrates of many known zinc-dependent ADHs. The enzyme actually prefers substrates with the reactive carbonyl function being located inside a cyclohexyl or cyclopentyl structure
Products: -

?

6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD+

6-oxocyclohex-1-ene-1-carbonyl-CoA + NADH + H+

Thauera aromatica

O87871

724904

Substrates: the enzyme participates in the central benzoyl-CoA degradation pathway of some anaerobic bacteria
Products: -

ir

6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD+

6-oxocyclohex-1-ene-1-carbonyl-CoA + NADH + H+

Thauera aromatica

O87871

724904

Substrates: the enzyme is specific for NAD+, no activity with NADP+. The enzyme is specific for 6-hydroxycyclohex-1-ene-1-carbonyl-CoA, no activity with 2-hydroxycyclohexane-1-carbonyl-CoA
Products: -

ir

6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD+

6-oxocyclohex-1-ene-1-carbonyl-CoA + NADH + H+

Thauera aromatica

-

741556

Substrates: -
Products: -

?