EC 1.1.1.280: (S)-3-hydroxyacid-ester dehydrogenase

This is an abbreviated version!
For detailed information about (S)-3-hydroxyacid-ester dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.280

1.1.1.280

branched-chain

transaminase

glioblastoma

neoplasia

non-neoplastic

invasiveness

hypermethylation

synthesis

Reaction

Show molfile — ethyl (S)-3-hydroxyhexanoate

Synonyms

2-methyl-3-oxobutanoate reductase, 3-oxo ester (S)-reductase, EC 1.2.1.56, reductase, 3-oxo ester (S)-

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.280 (S)-3-hydroxyacid-ester dehydrogenase

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All data fields related to EC 1.1.1.280
Results	in table
2	Application
1	CAS Registry Number
2	Cofactor
8	Inhibitors
6	KM Value [mM]
1	Localization
4	Molecular Weight [Da]
3	Organism
3	pH Optimum
1	pH Stability
2	Purification (Commentary)
1	Reaction
3	Reaction Type
3	Reference
1	Specific Activity [micromol/min/mg]
16	Substrates and Products (Substrate)
3	Subunits
4	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]

Substrates Products

Substrates Products on EC 1.1.1.280 - (S)-3-hydroxyacid-ester dehydrogenase

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2-methyl-3-oxobutanoate + NADPH + H+

(2R,3S)-3-hydroxy-2-methylbutanoate + NADP+

Klebsiella pneumoniae

639094

Substrates: -
Products: -

4-oxopentanoate + NADPH

(S)-4-hydroxypentanoate + NADP+

Saccharomyces cerevisiae

639092

Substrates: -
Products: -

5-oxohexanoate + NADPH

(S)-5-hydroxyhexanoate + NADP+

Saccharomyces cerevisiae

639092

Substrates: -
Products: -

benzyl 2-methyl-3-oxobutanoate + NADPH

benzyl (2R,3S)-3-hydroxy-2-methylbutanoate + NADP+

2 entries

ethyl 2-methyl-3-oxobutanoate + NADPH

ethyl (2R,3S)-3-hydroxy-2-methylbutanoate + NADP+

2 entries

ethyl 2-oxocyclohexanecarboxylate + NADPH

ethyl (1R,2S)-2-hydroxycyclohexanecarboxylate + NADP+

2 entries

ethyl 2-oxocyclopentanecarboxylate + NADPH

ethyl (1R,2S)-2-hydroxycyclopentanecarboxylate + NADP+

2 entries

ethyl 3-oxobutyrate + NADPH

ethyl (S)-3-hydroxybutyrate + NADP+

3 entries

ethyl 3-oxohexanoate + NADPH

ethyl (S)-3-hydroxyhexanoate + NADP+

Saccharomyces cerevisiae

639092

Substrates: -
Products: -

additional information

Klebsiella pneumoniae

639094

Substrates: ethyl (2R,3S)-3-hydroxy-2-methylbutanoate is a useful starting material for the synthesis of ferroelectric liquid crystal compounds and various other biologically active substances
Products: -