EC 1.1.1.238: 12beta-hydroxysteroid dehydrogenase

This is an abbreviated version!
For detailed information about 12beta-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

Synonyms

12beta-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.238 12beta-hydroxysteroid dehydrogenase

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All data fields related to EC 1.1.1.238

Results	in table
1	Application
1	CAS Registry Number
2	Cofactor
1	General Stability
9	KM Value [mM]
1	Localization
1	Molecular Weight [Da]
1	Organism
2	Pathway
2	pH Optimum
1	pH Range
1	pH Stability
1	Reaction
3	Reaction Type
1	Reference
2	Specific Activity [micromol/min/mg]
1	Storage Stability
8	Substrates and Products (Substrate)
1	Synonyms
1	Systematic Name
3	Temperature Stability [°C]

Substrates Products

Substrates Products on EC 1.1.1.238 - 12beta-hydroxysteroid dehydrogenase

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SUBSTRATE

PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

LITERATURE

COMMENTARY

Reversibility
r=reversible
ir=irreversible
?=not specified

3,12-dioxo-5beta-cholanoate + NADPH

12beta-hydroxy-3-oxo-5beta-cholanoate + NADP+

Clostridium paraputrificum

-

286353

Substrates: -
Products: -

?

3,7,12-trioxo-5beta-cholanoate + NADPH

12beta-hydroxy-3,7-dioxo-5beta-cholanoate + NADP+

Clostridium paraputrificum

-

286353

Substrates: -
Products: -

?

3,7,12-trioxotaureate + NADPH

12beta-hydroxy-3,7-dioxotaureate + NADP+

Clostridium paraputrificum

-

286353

Substrates: -
Products: -

?

3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanoate + NADPH

3alpha,7alpha,12beta-trihydroxy-5beta-cholanoate + NADP+

Clostridium paraputrificum

-

286353

Substrates: -
Products: -

?

3alpha-hydroxy-12-oxo-5beta-cholanoate + NADPH

3alpha,12beta-dihydroxy-5beta-cholanoate + NADP+

Clostridium paraputrificum

-

286353

Substrates: reverse reaction 10% the rate of forward reaction
Products: -

r

3alpha-hydroxy-7,12-dioxo-5beta-cholanoate + NADPH

3alpha,12beta-dihydroxy-7-oxo-5beta-cholanoate + NADP+

Clostridium paraputrificum

-

286353

Substrates: -
Products: -

?

7,12-dioxo-5beta-cholanoate + NADPH

12beta-hydroxy-7-oxo-5beta-cholanoate + NADP+

Clostridium paraputrificum

-

286353

Substrates: -
Products: -

?

7alpha-hydroxy-3,12-dioxo-5beta-cholanoate + NADPH

7alpha,12beta-dihydroxy-3-oxo-5beta-cholanoate + NADP+

Clostridium paraputrificum

-

286353

Substrates: -
Products: -

?