CARP3_CANAL

(Candidapepsin from Candida albicans (strain SC5314 / ATCC MYA-2876); EC 3.4.23.24)

Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave Leu15-Tyr, Tyr16-Leu and Phe24-Phe of insulin B chain. Activates trypsinogen, and degrades keratin

Accession Code:P0CY29
Organism:Candida albicans (strain SC5314 / ATCC MYA-2876)
Number of AA:398
Molecular Weight:42806
Source:Swiss-Prot
Sequences with same EC No.:


Sequence: ->fasta
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0  MFLKNIFIAL AIALLADATP TTFNNSPGFV ALNFDVIKTH KNVTGPQGEI NTNVNVKRQT
60  VPVKLINEQV SYASDITVGS NKQKLTVVID TGSSDLWVPD SQVSCQAGQG QDPNFCKNEG
120  TYSPSSSSSS QNLNSPFSIE YGDGTTSQGT WYKDTIGFGG ISITKQQFAD VTSTSVDQGI
180  LGIGYKTHEA EGNYDNVPVT LKNQGIISKN AYSLYLNSRQ ATSGQIIFGG VDNAKYSGTL
240  IALPVTSDNE LRIHLNTVKV AGQSINADVD VLLDSGTTIT YLQQGVADQV ISAFNGQETY
300  DANGNLFYLV DCNLSGSVDF AFDKNAKISV PASEFTAPLY TEDGQVYDQC QLLFGTSDYN
360  ILGDNFLRSA YIVYDLDDNE ISLAQVKYTT ASNIAALT

Data linked to the same EC Number and organism:
PDB ID: 10

Sequence related references:
Sequence ReferenceAuthorsTitleJournalVolumePagesYearLink to PubMed
73162Jones T.,Federspiel N.A.,Chibana H.,Dungan J.,Kalman S.,Magee B.B.,Newport G.,Thorstenson Y.R.,Agabian N.,Magee P.T.,Davis R.W.,Scherer S.The diploid genome sequence of Candida albicans.Proc. Natl. Acad. Sci. U.S.A.1017329 - 73342004 PubMed
73163Smolenski G.,Sullivan P.A.,Cutfield S.M.,Cutfield J.F.Analysis of secreted aspartic proteinases from Candida albicans: purification and characterization of individual Sap1, Sap2 and Sap3 isoenzymes.Microbiology143349 - 3561997 PubMed
73164Borelli C.,Ruge E.,Schaller M.,Monod M.,Korting H.C.,Huber R.,Maskos K.The crystal structure of the secreted aspartic proteinase 3 from Candida albicans and its complex with pepstatin A.Proteins68738 - 7482007 PubMed