PNMT_RAT

(phenylethanolamine N-methyltransferase from Rattus norvegicus; EC 2.1.1.28)

S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine

Accession Code:P10937
Organism:Rattus norvegicus
Number of AA:285
Molecular Weight:31670
Source:Swiss-Prot
Sequences with same EC No.:


Sequence: ->fasta
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0  MDRGSDPKHT AGMDSDSDPG QAEVALAYQR FEPRAYLRNN YAPPRGDLSN PDGVGPWKLR
60  CMAQVFATGE VSGQVLIDIG SGPTIYQLLS ACAHFEDITM TDFLEVNRQE LGLWLREEPG
120  AFDWSVYSQH VCLIEDKGES WQEKERQLRA RVKRVLPIDV HKPQPLGASG LAPLPADALV
180  SAFCLEAVSP DLPSFRQALY HITTLLRPGG NLLFIGALEE SWYLAGEARL SVVPVSEEEV
240  REALVCSGYE VRDLRTYIMP AHLRTGVDDV KGIFFAWAQK IEVQV

Data linked to the same EC Number and organism:
Application: 1
Inhibitors: 17
Ligands: 37
Natural Substrates/ Products (Substrates): 3
Product: 3
Purification (Commentary): 1
Reference by Title: 13
Source Tissue: 6
Specific Activity [micromol/min/mg]: 1
Substrate: 3
Substrates and Products (Substrate): 4
Synonyms: 1
Temperature Optimum [°C]: 1
Temperature Stability [°C]: 1
pH Optimum: 2
Cofactor: 1
Ki Value [mM]: 3
Natural Substrate: 3
Natural Product: 3
Organism_taxonomy_ncbi_term: 2
Application (protein specific): 1
Cofactor (protein specific): 1
Inhibitors (protein specific): 17
Ki Value [mM] (protein specific): 3
Natural Substrates/ Products (Substrates) (protein specific): 3
Purification (Commentary) (protein specific): 1
Reference by Title (protein specific): 13
Source Tissue (protein specific): 6
Specific Activity [micromol/min/mg] (protein specific): 1
Substrates and Products (Substrate) (protein specific): 4
Temperature Optimum [°C] (protein specific): 1
Temperature Stability [°C] (protein specific): 1
pH Optimum (protein specific): 2

Sequence related references:
Sequence ReferenceAuthorsTitleJournalVolumePagesYearLink to PubMed
54092Suh Y.H.,Chun Y.S.,Lee I.S.,Kim S.S.,Choi W.,Chong Y.H.,Hong L.,Kim S.H.,Park C.W.,Kim C.G.Complete nucleotide sequence and tissue-specific expression of the rat phenylethanolamine N-methyltransferase gene.J. Neurochem.631603 - 16081994 PubMed
54093Koike G.,Jacob H.J.,Krieger J.E.,Szpirer C.,Hoehe M.R.,Horiuchi M.,Dzau V.J.Investigation of the phenylethanolamine N-methyltransferase gene as a candidate gene for hypertension.Hypertension26595 - 6011995 PubMed
54094Weisberg E.P.,Baruchin A.,Stachowiak M.K.,Stricker E.M.,Zigmond M.J.,Kaplan B.B.Isolation of a rat adrenal cDNA clone encoding phenylethanolamine N-methyltransferase and cold-induced alterations in adrenal PNMT mRNA and protein.Brain Res. Mol. Brain Res.6159 - 1661989 PubMed
54095Mezey E.Cloning of the rat adrenal medullary phenylethanolamine-N-methyltransferase.Nucleic Acids Res.172125 - 21251989 PubMed