EC Number   |
Protein Variants |
Reference |
|---|
   3.4.21.B27 | C699A |
site-directed mutagenesis, the mutant activity with substrate transferrin receptor 1 is unaltered compared to the wild-type enzyme |
731888 |
| 3.4.21.B27 | C704A |
site-directed mutagenesis, the mutant activity with substrate transferrin receptor 1 is unaltered compared to the wild-type enzyme |
731888 |
| 3.4.21.B27 | D188G |
site-directed mutagenesis, the autocatalytic processing of the PC7 zymogen is severely impaired leading to accumulation of the inactive pro-enzyme |
731888 |
| 3.4.21.B27 | more |
generation of a frameshift fsL506P enzyme mutant. Construction of an enzyme PC7 chimera, in which the transmembrane domain and the cytosolic tail are replaced by that of the convertase furin, the mutant loses its ability to cleave the transferrin receptor. Identification of the KTECER100;LA cleavage site by site-directed mutagenesis |
731888 |
| 3.4.21.B27 | more |
knockout mice, significant change in the architecture of the thymus and spleen |
673911 |
| 3.4.21.B27 | more |
proprotein convertase PC7 can rescue proActivin-A cleavage in furin-depleted B16-F1 melanoma cells |
753199 |
| 3.4.21.B27 | R316C |
site-directed mutagenesis, the autocatalytic processing of the PC7 zymogen is severely impaired leading to accumulation of the inactive pro-enzyme |
731888 |
