EC Number   |
Protein Variants |
Reference |
|---|
   2.8.2.2 | A261T |
polymorphism of SULT2A1. The SULT2A1 SNP Ala261Thr has an allele frequency of 13% in African-American populations and is located within the dimerization motif, where it prevents formation of SULT2A1 dimers. But Ala261Thr still has 93% of the wild-type enzyme activity |
761169 |
| 2.8.2.2 | A63P |
polymorphism of SULT2A1. The SULT2A1 SNP Ala63Pro has an allele frequency of 5% in African-American populations |
761169 |
| 2.8.2.2 | D176N |
naturally occuring polymorphism in SULT2B1a |
675604 |
| 2.8.2.2 | L36S |
naturally occuring polymorphism in SULT2B1a |
675604 |
| 2.8.2.2 | M137I |
site-directed mutagenesis, substrate binding structure, the Ki for androsterone is increased 28.6fold compared to the wild-type enzyme, overview |
694259 |
| 2.8.2.2 | M137K |
site-directed mutagenesis, inactive mutant |
694259 |
| 2.8.2.2 | M137K/Y238A |
site-directed mutagenesis, inactive mutant |
694259 |
| 2.8.2.2 | M137V |
site-directed mutagenesis, substrate binding structure, the Ki for androsterone is increased 5fold and for dehydroepiandrosterone 9fold compared to the wild-type enzyme, overview |
694259 |
| 2.8.2.2 | M137V/Y238A |
site-directed mutagenesis, the mutant shows no substrate inhibition by dehydroepiandrosterone |
694259 |
| 2.8.2.2 | M137W |
site-directed mutagenesis, substrate binding structure, the Ki for androsterone is increased 11.1fold compared to the wild-type enzyme, overview |
694259 |
