EC Number   |
|---|
   2.4.1.41 | binary complex of UDP and ppGalNAcT-2 in crystal structure PDB: 2FFV |
| 2.4.1.41 | crystals of mppGaNTase-T1 (without maltose-binding protein) are grown by hanging drop vapor diffusion at room temperature |
| 2.4.1.41 | dynamics of loop A dependent on presence of ligand and state of loop B |
| 2.4.1.41 | dynamics of loop B reduced upon UDP-GalNAc (donor) binding but not further reduced by subsequent peptide (acceptor) binding |
| 2.4.1.41 | flexibility of terminal residues of EA2 peptide in EA2-enzyme complex is reduced upon presence of a GalNAc moiety |
| 2.4.1.41 | hanging drop vapor diffusion at room temperature. X-ray crystal structures of the enzyme bound to the product UDP at 2.75 A resolution and to UDP and an acceptor peptide substrate EA2 (PTTDSTTPAPTTK) at 1.64 A resolution |
| 2.4.1.41 | homology modeling of structure |
| 2.4.1.41 | in presence of UDP or UDP and peptide no water molecule-dependent, large conformational changes |
| 2.4.1.41 | low flexibility of EA2 peptide centre in EA2-enzyme complex |
| 2.4.1.41 | PDB: 2FFU incl. substrates versus PDB: 2FFU lacking substrates: flexibility of catalytic and lectin domain independent of each others presence or distance |
