EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   3.4.22.B71 | (SUMO-1)-Mdm2 conjugate + H2O |
- |
Mus musculus |
SUMO + Mdm2 |
- |
? |
| 3.4.22.B71 | (SUMO-1)-Mdm2 conjugate + H2O |
SUMO conjugation of Mdm2 induces its co-localization and association with SENP2 at the PML bodies. SENP2 catalyzes the desumoylation process of Mdm2. SENP2 mediated regulation of Mdm2 critical for genome integrity in p53-dependent stress responses |
Mus musculus |
SUMO + Mdm2 |
- |
? |
| 3.4.22.B71 | (SUMO-1)-Ran GTPase-activating protein 1 conjugate + H2O |
- |
Homo sapiens |
SUMO-1 + Ran GTPase-activating protein 1 |
- |
? |
| 3.4.22.B71 | (SUMO-2)-Ran GTPase-activating protein 1 conjugate + H2O |
- |
Homo sapiens |
SUMO-2 + Ran GTPase-activating protein 1 |
- |
? |
| 3.4.22.B71 | (SUMO-2/3)-Ran GTPase-activating protein 1 conjugate + H2O |
- |
Homo sapiens |
SUMO-2/3 + Ran GTPase-activating protein 1 |
- |
? |
| 3.4.22.B71 | (SUMO-3)-Ran GTPase-activating protein 1 conjugate + H2O |
- |
Homo sapiens |
SUMO-3 + Ran GTPase-activating protein 1 |
- |
? |
| 3.4.22.B71 | acetyl-QTGG-7-amino-4-trifluoromethylcoumarin + H2O |
- |
Homo sapiens |
acetyl-QTGG + 7-amino-4-trifluoromethylcoumarin |
- |
? |
| 3.4.22.B71 | diSUMO2 + H2O |
- |
Homo sapiens |
2 SUMO2 |
- |
? |
| 3.4.22.B71 | more |
nucleoporin Nup153 binds to SENP2 by interacting with the unique N-terminal domain of Nup153 as well as a specific region within the C-terminal FG-rich region. Nup153 is a substrate for SUMOylation, with this modification kept in check by the SUMO protease |
Homo sapiens |
? |
- |
? |
| 3.4.22.B71 | poly-SUMO-2/3-Aurora-B conjugate + H2O |
specifically deconjugates SUMO from mitotic kinase Aurora-B. Lys202 on human Aurora-B is preferentially modified by SUMO, and enhancement of SUMOylation in cells facilitates Aurora-B autophosphorylation, which is essential for its activation. Conversely, SENP2-mediated deSUMOylation of Aurora-B down-regulates its autophosphorylation in cells and also impairs its re-activation in Aurora inhibitor VX-680-treated mitotic cells. Poly-SUMO-2 conjugation of Aurora-B occurs during the M phase ofthe cell cycle, and both SUMO-2 and PIAS3 are localized adjacent to Aurora-B in the kinetochores in early mitosis. Aurora-B is a mitotic SUMO substrate and its kinase activity is fine-tuned by the SUMO system |
Homo sapiens |
? |
- |
? |
