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Results 1 - 7 of 7

EC Number	Substrates	Commentary Substrates	Organism	Products	Commentary (Products)	Reversibility
3.1.27.8	more	endonuclease Vs are inosine-specific nucleases that cleave at the second phosphodiester bond 3' to inosine. The human enzyme is most active towards ssRNA but is much less active towards other substrates	Homo sapiens	?	-	?
3.1.27.8	more	the human endonuclease V ribonuclease is specific for inosine-containing RNA, it preferentially binds to RNA and efficiently hydrolyses the second phosphodiester bond located 3' to the inosine in unpaired inosine-containing ssRNA regions in dsRNA, at 5'-IIUI-3' and 5'-UIUU-3'. But hEndoV can also cleave ssDNA substrates containing deoxyinosine. RNA is preferred to DNA by the enzyme as a substrate	Homo sapiens	?	-	?
3.1.27.8	more	32P-labelled 30mer ssDNA containing deoxyinosine and/or 21mer ssRNA containing inosine are used as substrates, as well as 32P-labelled 30mer ssDNA containing deoxyinosine	Homo sapiens	?	-	?
3.1.27.8	more	single-stranded deoxyinosine-containing DNA (5'-GCTCGGCTICGGACCGAG-3') and inosine-containing RNA (5'-CUGACUICGGAUCAGGGCC-3') oligonucleotides are synthesized and used as substrates. Substrate-recognition specificity, overview	Homo sapiens	?	-	?
3.1.27.8	Poly(A) + H2O	-	Bos taurus	3'-AMP	-	?
3.1.27.8	Poly(U) + H2O	-	Bos taurus	3'-UMP	-	?
3.1.27.8	rRNA + H2O	-	Bos taurus	?	-	?

Results 1 - 7 of 7

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Release 2023.1 (January 2023)