EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   2.5.1.89 | (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate |
about 35% of the activity with geranylgeranyl diphosphate |
Sulfolobus acidocaldarius |
8 diphosphate + ditrans,octacis-undecaprenyl diphosphate |
- |
? |
| 2.5.1.89 | all-trans-geranylfarnesyl diphosphate + 6 isopentenyl diphosphate |
- |
Aeropyrum pernix |
6 diphosphate + hexatrans,tetracis-undecaprenyl diphosphate |
- |
? |
| 2.5.1.89 | all-trans-geranylfarnesyl diphosphate + 6 isopentenyl diphosphate |
- |
Aeropyrum pernix |
6 diphosphate + hexatrans,tetracis-undecaprenyl diphosphate |
i.e. (Z,Z,Z,Z,Z,Z,E,E,E,E)-UPP [(2Z,6Z,10Z,14Z,18Z,22Z,26E,30E,34E,38E)-3,7,11,15,19,23,27,31,35,39,43-undecamethyl-2,6,10,14,18,22,26,30,34,38,42-tetratetracontaundecaen-1-yl diphosphate] |
? |
| 2.5.1.89 | all-trans-geranylfarnesyl diphosphate + 6 isopentenyl diphosphate |
- |
Aeropyrum pernix DSM 11879 |
6 diphosphate + hexatrans,tetracis-undecaprenyl diphosphate |
- |
? |
| 2.5.1.89 | geranylgeranyl diphosphate + 7 isopentenyl diphosphate |
- |
Sulfolobus acidocaldarius |
7 diphosphate + tritrans,heptacis-undecaprenyl diphosphate |
- |
? |
| 2.5.1.89 | more |
dimethylallyl diphosphate and geranyl diphosphate scarcely react |
Sulfolobus acidocaldarius |
? |
- |
? |
| 2.5.1.89 | more |
the undecaprenyl diphosphate synthase from Aeropyrum pernix that has anomalous substrate specificity, due to the fact that only dimethylallyl diphosphate and geranylfarnesyl diphosphate, both of which are unusual substrates for known cis-prenyltransferases, are likely available as an allylic primer substrate for the archaeal enzyme |
Aeropyrum pernix |
? |
- |
? |
| 2.5.1.89 | more |
the enzyme is a cis-prenyltransferas, determination of substrate specificity, product chain-length, and cofactor requirement, overview. The most preferred allylic substrates are farnesyl diphosphate and geranylfarnesyl diphosphate, the main product is UPP, regardless of the substrate. When the ratio of IPP to geranylfarnesyl diphosphate is decreased to 1, the UPP synthase predominately yields shorter C30-45 products. When the ratio is increased to 100, the main product is C60 dodecaprenyl diphosphate. The chain-length of the product of UPP synthase, which determines the structure of the glycosyl carrier lipid, is variable depending on the substrate ratio in the cells of Aeropyrum pernix. A 10fold increase in the substrate ratio results in a significant rise in the production of all-trans-hexaprenyl diphosphate. No activity with dimethylallyl diphosphate. The enzyme also shows the activity of hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific], EC 2.5.1.82, and of geranylgeranyl diphosphate synthase, EC 2.5.1.29 |
Aeropyrum pernix |
? |
- |
? |
| 2.5.1.89 | more |
the undecaprenyl diphosphate synthase from Aeropyrum pernix that has anomalous substrate specificity, due to the fact that only dimethylallyl diphosphate and geranylfarnesyl diphosphate, both of which are unusual substrates for known cis-prenyltransferases, are likely available as an allylic primer substrate for the archaeal enzyme |
Aeropyrum pernix DSM 11879 |
? |
- |
? |
| 2.5.1.89 | more |
the enzyme is a cis-prenyltransferas, determination of substrate specificity, product chain-length, and cofactor requirement, overview. The most preferred allylic substrates are farnesyl diphosphate and geranylfarnesyl diphosphate, the main product is UPP, regardless of the substrate. When the ratio of IPP to geranylfarnesyl diphosphate is decreased to 1, the UPP synthase predominately yields shorter C30-45 products. When the ratio is increased to 100, the main product is C60 dodecaprenyl diphosphate. The chain-length of the product of UPP synthase, which determines the structure of the glycosyl carrier lipid, is variable depending on the substrate ratio in the cells of Aeropyrum pernix. A 10fold increase in the substrate ratio results in a significant rise in the production of all-trans-hexaprenyl diphosphate. No activity with dimethylallyl diphosphate. The enzyme also shows the activity of hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific], EC 2.5.1.82, and of geranylgeranyl diphosphate synthase, EC 2.5.1.29 |
Aeropyrum pernix DSM 11879 |
? |
- |
? |
