EC Number   |
Specific Activity Minimum [µmol/min/mg] |
Specific Activity Maximum [µmol/min/mg] |
Reference |
|---|
    4.4.1.5 | -999 |
- |
- |
37422, 37429, 37456 |
| 4.4.1.5 | -999 |
- |
23 U/mg protein wild type, 19 U/mg protein ectopic control mutant Gox1-2 |
664682 |
| 4.4.1.5 | -999 |
- |
40 nmol/min/mg Leishmania major extract, trypanothione, pH 7.0, 27°C. Below 5 nmol/min/mg Leishmania major extract, pH 7.0, 27°C |
666709 |
| 4.4.1.5 | -999 |
- |
8fold higher activity than in non-cancerous cells |
654009 |
| 4.4.1.5 | -999 |
- |
activity of glyoxalase I in Pisum sativum shows linear progression with development of shoots and roots of seedlings, cell division and proliferation further modulate the activity |
692050 |
| 4.4.1.5 | -999 |
- |
determined spectrophotometrically at 240 nm, glyoxalase I activities for 2-methyl-4-dimethylaminoazobenzene-fed rats (10 weeks fed) are 1.7times higher than that of control animals |
690300 |
| 4.4.1.5 | -999 |
- |
determined spectrophotometrically at 240 nm, glyoxalase I activities for 3'-methyl-4-dimethylaminoazobenzene-fed rats (10 weeks fed) are 1.6times higher than that of control animals |
690300 |
| 4.4.1.5 | -999 |
- |
determined spectrophotometrically at 240 nm, glyoxalase I activities for 4'-methyl-4-dimethylaminoazobenzene-fed rats (10 weeks fed) are 1.5times higher than that of control animals |
690300 |
| 4.4.1.5 | -999 |
- |
enzyme activity decreases significantly from 0.2 U/single Caenorhabditis elegans at day 1 to 0.02 U/single Caenorhabditis elegans at day 12. In contrast mRNA expression of the homologue, CeGly did not decrease at day 12 but slightly increase, suggesting that post-transciptional modification of glyoxalase-1 protein, rather than decrease transcription, accounted for the age-related decrease in enzyme activity. The glyoxalase-1 homologue CeGly is subcloned into a Green Fluorescent Protein (GFP) vector under control of its native promotor. Enzymatic activity of CeGly in cultures of age-synchronized 1-day-old transgenic Caenorhabditis elegans overexpressing CeGly is ca. 200fold higher than in the wild-type strain. Increased enzymatic activity in transgenic animals results in a significant reduction of both methylglyoxal and methylglyoxal-derived arginine- and lysine-derived adducts. Increased glyxalase-1 activity significantly prolongs lifespan. Mean lifespan increases in transgenic animals from 13.3 days to 17.2 days and maximum lifespan from 28 days to 37 days |
690310 |
| 4.4.1.5 | -999 |
- |
ischemia/reperfusion induces the reduction of GLO I activity in the kidney, which is asssociated with morphological damage and renal dysfunction |
690439 |
