EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.1 | alcohol dehydrogenase |
colon |
low expression level of ADH5 |
722013 |
1.1.1.102 | 3-dehydrosphinganine reductase |
colon |
low expression |
656256 |
1.1.1.105 | all-trans-retinol dehydrogenase (NAD+) |
colon |
- |
761505 |
1.1.1.141 | 15-hydroxyprostaglandin dehydrogenase (NAD+) |
colon |
- |
667147 |
1.1.1.141 | 15-hydroxyprostaglandin dehydrogenase (NAD+) |
colon |
distribution of enzyme expression within the tissue in situ, overview |
-, 670691 |
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase |
colon |
- |
700178, 740917 |
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase |
colon |
colonic tissue from inflammatory bowel disease patients and healthy controls |
760956 |
1.1.1.153 | sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) |
colon |
- |
761589 |
1.1.1.184 | carbonyl reductase (NADPH) |
colon |
- |
697582 |
1.1.1.184 | carbonyl reductase (NADPH) |
colon |
low expression of CBR3 |
697582 |
1.1.1.21 | aldose reductase |
colon |
- |
697266 |
1.1.1.213 | 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific) |
colon |
- |
724719 |
1.1.1.218 | morphine 6-dehydrogenase |
colon |
in male hamsters |
740637 |
1.1.1.239 | 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) |
colon |
- |
724719 |
1.1.1.239 | 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) |
colon |
high expression level of AKR1C27 |
739953 |
1.1.1.239 | 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) |
colon |
high expression level of AKR1C28 |
739953 |
1.1.1.239 | 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) |
colon |
in male hamsters |
740637 |
1.1.1.270 | 3beta-hydroxysteroid 3-dehydrogenase |
colon |
- |
724124 |
1.1.1.278 | 3beta-hydroxy-5alpha-steroid dehydrogenase |
colon |
- |
639086 |
1.1.1.315 | 11-cis-retinol dehydrogenase |
colon |
45% mRNA expression of Rdh5 compared to liver |
690797 |
1.1.1.315 | 11-cis-retinol dehydrogenase |
colon |
45% of the expression in liver |
690797 |
1.1.1.50 | 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) |
colon |
- |
389547 |
1.1.1.51 | 3(or 17)beta-hydroxysteroid dehydrogenase |
colon |
in female and male hamsters |
740637 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
colon |
- |
654934 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
colon |
HSD17B2 is normally expressed in the epithelial cells of the colon lumen, and to a lesser extent in the crypt epithelium small intestine endometrium |
762074 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
colon |
low mRNA expression |
688007 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
colon |
type 7 17beta-hydroxysteroid dehydrogenase is restricted to epithelial cells of the mucosa |
670031 |
1.1.1.64 | testosterone 17beta-dehydrogenase (NADP+) |
colon |
- |
724719 |
1.1.1.B40 | 11beta-hydroxysteroid dehydrogenase (NAD+) |
colon |
- |
285953, 700178 |
1.1.1.B40 | 11beta-hydroxysteroid dehydrogenase (NAD+) |
colon |
high level of expression and activity |
695148 |
1.11.1.12 | phospholipid-hydroperoxide glutathione peroxidase |
colon |
- |
671327 |
1.11.1.7 | peroxidase |
colon |
- |
698048 |
1.11.1.9 | glutathione peroxidase |
colon |
- |
685921, 725056 |
1.11.1.9 | glutathione peroxidase |
colon |
potential for Gpx1 and Gpx2 redundancy in lymphatic tissue, but not in epithelial cells of the colon crypt or in the lamina propria, sub-mucosa, muscularis or serosa |
673632 |
1.13.11.31 | arachidonate 12-lipoxygenase |
colon |
low activity |
395410 |
1.13.11.33 | arachidonate 15-lipoxygenase |
colon |
15-LOX-1 but not 15-LOX-2 |
706877 |
1.13.11.5 | homogentisate 1,2-dioxygenase |
colon |
- |
439387 |
1.13.11.52 | indoleamine 2,3-dioxygenase |
colon |
- |
665457, 671714, 712112 |
1.13.11.63 | beta-carotene 15,15'-dioxygenase |
colon |
- |
713952, 728342 |
1.14.11.1 | gamma-butyrobetaine dioxygenase |
colon |
- |
697453, 699163 |
1.14.11.33 | DNA oxidative demethylase |
colon |
high ABH3 mRNA levels |
723671 |
1.14.11.4 | procollagen-lysine 5-dioxygenase |
colon |
distal |
657744 |
1.14.11.65 | [histone H3]-dimethyl-L-lysine9 demethylase |
colon |
- |
755238 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
colon |
iNOS |
684317 |
1.14.14.115 | 11-oxo-beta-amyrin 30-oxidase |
colon |
- |
716523 |
1.14.14.18 | heme oxygenase (biliverdin-producing) |
colon |
- |
686565 |
1.14.14.29 | 25/26-hydroxycholesterol 7alpha-hydroxylase |
colon |
- |
659660 |
1.14.15.16 | vitamin D3 24-hydroxylase |
colon |
- |
714836 |
1.14.15.18 | calcidiol 1-monooxygenase |
colon |
- |
675686, 712885 |
1.14.15.18 | calcidiol 1-monooxygenase |
colon |
healthy and malignant, high expression level, 1alpha-hydroxylase is present at equal high levels in normal colonic epithelium as in ACFs, polyps, and colorectal cancer irrespective of tumor cell differentiation |
672882 |
1.14.15.18 | calcidiol 1-monooxygenase |
colon |
tissue-specific enzyme regulation |
672936 |
1.14.16.4 | tryptophan 5-monooxygenase |
colon |
- |
746550 |
1.14.18.2 | CMP-N-acetylneuraminate monooxygenase |
colon |
- |
711142 |
1.14.18.6 | 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase |
colon |
- |
734146 |
1.14.19.1 | stearoyl-CoA 9-desaturase |
colon |
- |
746444 |
1.14.99.38 | cholesterol 25-monooxygenase |
colon |
- |
700999 |
1.14.99.66 | [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase |
colon |
- |
755238 |
1.17.3.2 | xanthine oxidase |
colon |
- |
689189 |
1.2.1.25 | branched-chain alpha-keto acid dehydrogenase system |
colon |
- |
762596 |
1.2.1.3 | aldehyde dehydrogenase (NAD+) |
colon |
- |
692281, 712435 |
1.2.1.31 | L-aminoadipate-semialdehyde dehydrogenase |
colon |
- |
288202, 675897 |
1.2.1.31 | L-aminoadipate-semialdehyde dehydrogenase |
colon |
mRNA expression |
675897 |
1.21.99.4 | thyroxine 5'-deiodinase |
colon |
low level of activity |
659941 |
1.3.1.38 | trans-2-enoyl-CoA reductase (NADPH) |
colon |
TER mRNA |
656193 |
1.3.1.70 | DELTA14-sterol reductase |
colon |
highest expression |
765069 |
1.3.1.70 | DELTA14-sterol reductase |
colon |
LBR |
672378 |
1.3.1.72 | DELTA24-sterol reductase |
colon |
- |
745890 |
1.3.5.2 | dihydroorotate dehydrogenase (quinone) |
colon |
- |
390925 |
1.4.3.13 | protein-lysine 6-oxidase |
colon |
- |
674712 |
1.4.3.13 | protein-lysine 6-oxidase |
colon |
localization of LOX and LOXL in different tissue areas, LOXL is found in the apical surface of columnar absorbing cells, LOX is located in the submucosa |
659751 |
1.4.3.22 | diamine oxidase |
colon |
ascending, descending and transverse |
656295 |
1.4.3.5 | pyridoxal 5'-phosphate synthase |
colon |
1.2% of the activity in liver detected in ascending colon, 7.9% of the activity in liver is detected in transverse colon, 2.8% of the activity in liver is detected in descending colon |
655483 |
1.5.1.2 | pyrroline-5-carboxylate reductase |
colon |
- |
392066 |
1.5.1.20 | methylenetetrahydrofolate reductase [NAD(P)H] |
colon |
- |
712182 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
colon |
- |
710782, 711688, 742557 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
colon |
Nox1 is most highly expressed in colon epithelium. In colon the cytosolic subunits p47phox and p67phox are not expressed and are replaced by Noxo1 and Noxa1 |
724778 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
colon |
sigmoidal colon, high expression |
671214 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
colon |
the potent anti-inflammatory, cytokine interleukin-10, acts as a down-regulator of the Nox1-based oxidase in the colon, and suggests an important role of ROS derived from Nox1-based oxidase in the initiation of inflammatory responses of the colon |
699287 |
1.6.5.2 | NAD(P)H dehydrogenase (quinone) |
colon |
- |
731541 |
1.7.1.7 | GMP reductase |
colon |
expressed at low levels |
394294 |
1.8.1.8 | protein-disulfide reductase |
colon |
- |
687756 |
1.8.3.1 | sulfite oxidase |
colon |
little expression |
657738 |
1.8.4.12 | peptide-methionine (R)-S-oxide reductase |
colon |
- |
712462 |
1.8.4.12 | peptide-methionine (R)-S-oxide reductase |
colon |
isozymes MsrB3 and MsrB2 |
669008 |
1.8.5.1 | glutathione dehydrogenase (ascorbate) |
colon |
- |
394033 |
1.8.5.4 | bacterial sulfide:quinone reductase |
colon |
- |
742246 |
1.8.5.4 | bacterial sulfide:quinone reductase |
colon |
termination of endogenous H2S signalling in the colonic muscularis externa occurs via catabolism to thiosulfate and sulfate partially via a mechanism involving sulfide:quinone reductase |
724681 |
2.1.1.17 | phosphatidylethanolamine N-methyltransferase |
colon |
- |
485173 |
2.1.1.20 | glycine N-methyltransferase |
colon |
GNMT is expressed in the epithelium of the colon under normal conditions, and with dextran sulfate sodium treatment, its expression is predominant in infiltrated leukocytes of lesions |
734396 |
2.1.1.45 | thymidylate synthase |
colon |
adenocarcinoma |
485395 |
2.1.1.61 | tRNA 5-(aminomethyl)-2-thiouridylate-methyltransferase |
colon |
low level |
671744 |
2.1.1.63 | methylated-DNA-[protein]-cysteine S-methyltransferase |
colon |
- |
673219, 704064, 733613, 734744 |
2.1.1.72 | site-specific DNA-methyltransferase (adenine-specific) |
colon |
- |
719373 |
2.1.1.8 | histamine N-methyltransferase |
colon |
HMT activity comparable to activity in the jejunum |
677114 |
2.3.1.1 | amino-acid N-acetyltransferase |
colon |
- |
486070 |
2.3.1.118 | N-hydroxyarylamine O-acetyltransferase |
colon |
- |
486162 |
2.3.1.118 | N-hydroxyarylamine O-acetyltransferase |
colon |
different phenotypes |
487133 |
2.3.1.15 | glycerol-3-phosphate 1-O-acyltransferase |
colon |
- |
676839, 756106 |
2.3.1.21 | carnitine O-palmitoyltransferase |
colon |
low level of expression of CPT1-C |
659899 |
2.3.1.225 | protein S-acyltransferase |
colon |
DHHC9 |
720174 |