EC Number   |
General Information |
Reference |
|---|
    6.1.1.6 | evolution |
all sequenced strains of Bacillus cereus, except strain AH820, encode both a class I and a class II LysRSs |
-, 714617 |
| 6.1.1.6 | evolution |
multiple genes encode for aminoacyl-tRNA synthetases from Mycobacterium smegmatis, e.g. glutamyl (GluRS), cysteinyl (CysRS), prolyl (ProRS) and lysyl (LysRS) tRNA synthetases. Conditional expression strains of lysyl-tRNA synthetases generated in Mycobacterium smegmatis reveals that the canonical aminoacyl-tRNA synthetase are essential, while the additional ones are not essential for the growth of Mycobacterium smegmatis. The lysyl-tRNA synthetase of Mycobacterium smegmatis belongs to the class II amino acid tRNA synthetases |
-, 746197 |
| 6.1.1.6 | evolution |
the enzyme belongs to the class II amino acyl-tRNA synthetases (aaRS) |
-, 745539 |
| 6.1.1.6 | evolution |
the enzyme belongs to the class II aminoacyl-tRNA synthetases |
744902 |
| 6.1.1.6 | evolution |
the lysyl-tRNA synthetase of Mycobacterium smegmatis belongs to the class II amino acid tRNA synthetases |
-, 744162 |
| 6.1.1.6 | malfunction |
aberrant expression of aminoacyl-tRNA synthetases is associated with various human cancers. Enzyme status and clinicopathological parameters reveal that the enzyme expression is correlated with a shorter overall survival. Enzyme KRS has an oncogenic role, it binds microphthalmia-associated transcription factor (MITF), which is an oncogenic transcriptional activator observed in the development of melanoma |
744045 |
| 6.1.1.6 | malfunction |
congenital visual impairment and progressive microcephaly due to lysyl-transfer RNA synthetase (KARS) mutations, expanding phenotype with severe infantile visual loss, progressive microcephaly, developmental delay, seizures, and abnormal subcortical white matter, overview |
745444 |
| 6.1.1.6 | malfunction |
cytosolic KRS is released from MSC and translocates to the cell membrane, where it binds to p67LR. BC-K01 and YH16899 to KRS abolishes the KRS-LR interaction |
744423 |
| 6.1.1.6 | malfunction |
depletion of KARS with small interfering RNAs suppresses calreticulin exposure on the cell surface induced by anthracyclines or UVC light |
714671 |
| 6.1.1.6 | malfunction |
effects of krs deletion on radial growth, conidiation capacity, and conidial quality. No significant growth defect occurred in the mutant grown on the carbon sources of sucrose and trehalose and the nitrogen sources of ten other amino acids tested. The DELTAkrs mutant exhibits a significant decrease of conidial yield by 47% on day 5 and 15-21% on days 6-8, delayed conidiation is evidenced with transcriptional repression (62-80%) of the conidiation-required genes fluG, brlA, abaA, and wetA compared to control. the hyphal bodies of Dkrs are not present in the insect haemolymph until day 7, indicating a retard of its dimorphic transition in vivo in comparison to the control strains that form abundant hyphal bodies on day 4 after the infection passing or bypassing the insect cuticle |
-, 745017 |
