EC Number   |
General Information |
Reference |
|---|
   3.4.22.56 | evolution |
caspase-3 is an executioner caspase |
717272 |
| 3.4.22.56 | evolution |
caspases-3 is a member of the cysteine-aspartic acid protease (caspase) family, fish caspase-3 subgroup. Lyccasp3 exhibits a conserved caspase-3 architecture including a prodomain, a large subunit and a small subunit. Several residues critical in the caspase-3 catalytic centre and binding pocket, as well as the active-site pentapeptide motif Q172ACRG176, are present in the deduced Lyccasp3 sequence, phylogenetic tree, overview |
717617 |
| 3.4.22.56 | malfunction |
caspase-3-specific inhibition augments RANKL-induced osteoclast differentiation in RAW264 cells and mouse bone marrow macrophages |
731594 |
| 3.4.22.56 | malfunction |
in mice with a muscle wasting condition, chronic kidney disease, occurs cleavage of subunits Rpt2 and Rpt6 and stimulation of proteasome activity |
717792 |
| 3.4.22.56 | malfunction |
mutations disrupting the cleavage activity or the p3 recognition site cause a defect in the nuclear entry of active caspase-3 |
717462 |
| 3.4.22.56 | metabolism |
the intrinsic apoptotic pathway, which is initiated by caspase-9 and executed by caspase-3, is activated during the immune response induced by poly(I:C) or bacterial vaccine in the fish |
717617 |
| 3.4.22.56 | metabolism |
the stage of muscle cell differentiation determines not only the caspase-3-induced subunit cleavage patterns but also the changes in proteasome activity |
717792 |
| 3.4.22.56 | metabolism |
tumour necrosis factor, TNF, induced ceramide production by endosomal acid sphingomyelinase, A-SMase, couples to apoptosis signalling via activation of cathepsin D and cleavage of Bid, resulting in caspase-9 and caspase-3 activation |
717539 |
| 3.4.22.56 | more |
active caspase-3 does not colocalize with internalized TNF-R1 receptosomes |
717539 |
| 3.4.22.56 | more |
tichothecin induces apoptosis of HepG2 cells via caspase-9 mediated activation of the mitochondrial death pathway. Trichothecin increases caspase-9 expression and caspase-3 activity |
718432 |
