EC Number   |
General Information |
Reference |
|---|
   3.4.21.B39 | malfunction |
kallikrein 5 induces atopic dermatitis-like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome, phenotype, overview |
709319 |
| 3.4.21.B39 | malfunction |
KLK5 and KLK7 are underexpressed in parallel, potentially with the same regulation pathways, in breast malignancies, which might contribute to the carcinogenesis and development of breast cancer |
707996 |
| 3.4.21.B39 | malfunction |
KLK5 knockdown in normal cultured human epidermal keratinocytes results in higher levels of profilaggrin |
732104 |
| 3.4.21.B39 | malfunction |
knockdown of kallikrein-5 expression reduces processing of desmoglein 1 |
717868 |
| 3.4.21.B39 | malfunction |
Netherton syndrome is a rare and debilitating severe autosomal recessive genetic skin disease with high mortality rates particularly in neonates. NS is caused by loss-of-function SPINK5 mutations leading to unregulated kallikrein 5 and kallikrein 7 activity |
753016 |
| 3.4.21.B39 | malfunction |
the role of skin pH in the pathogenesis of atopic dermatitis is explored using the NC/Tnd murine atopic dermatitis model. Alterations in skin pH directly modulate kallikrein 5 activity leading to skin barrier dysfunction, itch, and dermatitis via the protease-activated receptor 2 thymic stromal lymphopoietin pathway |
754353 |
| 3.4.21.B39 | metabolism |
KLK5 is part of an original biological cascade in which unregulated KLK5 directly activates proteinase-activated receptor 2 and induces nuclear factor kappaB-mediated overexpression of TSLP, intercellular adhesion molecule 1, tumor necrosis factor alpha, and IL8. This proinflammatory and proallergic pathway is independent of the primary epithelial failure and is activated under basal conditions in NS keratinocytes |
709319 |
| 3.4.21.B39 | more |
potential role of endogenous KLK5 expression in supporting CaP cells to cope with the cytostatic phenomena induced by chemotherapeutic agents practiced in standard first-line CaP chemotherapy |
707624 |
| 3.4.21.B39 | physiological function |
kallikrein 5 is implicated in the destruction of corneodesomosomes |
717412 |
| 3.4.21.B39 | physiological function |
kallikrein-5 promotes metastatic dissemination of oral squamous cell carcinoma cells by promoting loss of junctional integrity through cleavage of desmoglein 1 |
717868 |
