EC Number   |
General Information |
Reference |
|---|
   3.4.21.B27 | evolution |
four of nine conserved proprotein convertases (PCs), including furin, Pace4, PC5A/B, and PC7, cleave substrates after the minimal dibasic recognition motif (K/R)-(X)n-(K/R)Y, where n is 0, 2, 4, or 6 and X can be any amino acid. In 152 PC sequences examined across species, the catalytic sites are 95% identical |
753199 |
| 3.4.21.B27 | evolution |
the enzyme is a member of the subtilisin/kexin family of pro-protein convertases |
732699 |
| 3.4.21.B27 | malfunction |
an enzyme PC7 chimera, in which the transmembrane domain and the cytosolic tail are replaced by that of the convertase furin, loses its ability to cleave the transferrin receptor |
731888 |
| 3.4.21.B27 | malfunction |
cells silenced for proprotein convertase 7 have substantially reduced MHC class I surface levels caused by high instability and significantly delayed surface accumulation of these molecules |
717930 |
| 3.4.21.B27 | malfunction |
enzyme loss of function suppresses markers for anterior patterning of neural tissues and early eye development |
732699 |
| 3.4.21.B27 | malfunction |
inhibiting the enzyme in zebrafish results in various developmental defects and dysregulation of gene expressions, phenotypes, overview |
732122 |
| 3.4.21.B27 | malfunction |
the PLC motif in the cytosolic tail of proprotein convertase 7 (PC7) is dispensable for endosomal activity, but is specifically required for trans-Golgi network (TGN) recycling and to rescue proactivin-A cleavage in furin-depleted B16-F1 melanoma cells. In sharp contrast, PC7 complements furin in cleaving Notch1 independently of PLC-mediated TGN access |
753199 |
| 3.4.21.B27 | metabolism |
all proprotein convertase (PC) activity detected in the trans-Golgi network/endosomal system of B16-F1 cells is mediated by furin, but not by endogenous PC7. Enzyme PC7 can rescue proActivin-A cleavage in furin-depleted B16-F1 melanoma cells |
753199 |
| 3.4.21.B27 | metabolism |
when iron is limiting, human transferrin receptor TfR1 levels increase at least in part by way of the down-regulation of PC7 enzyme expression |
731888 |
| 3.4.21.B27 | more |
a PLC motif in the cytosolic tail of PC7 is dispensable for endosomal activity, but it is specifically required for trans-Golgi network recycling and to rescue proActivin-A cleavage in furin-depleted B16-F1 melanoma cells |
753199 |
