EC Number   |
General Information |
Reference |
|---|
   3.1.4.35 | evolution |
mechanisms for PDE activation are similar in mammalian and amphibian photoreceptors as well as in rods and cones |
716199 |
| 3.1.4.35 | malfunction |
chronic inhibition of phosphodiesterase 5 does not prevent pressure-overload-induced right-ventricular myocardial remodeling |
711687 |
| 3.1.4.35 | malfunction |
decreasing effect of PDE5 inhibition on vascular contractility, overview |
-, 715153 |
| 3.1.4.35 | malfunction |
disruption of the cyclic nucleotide phosphodiesterase PDEdelta gene causes significantly reduced cGMP-PDE activity and greatly reduced ability to undergo gametogenesis |
713049 |
| 3.1.4.35 | malfunction |
enhanced cGMP-dependent protein kinase activity by PDE5 inhibition negatively regulates ERK1/2 activity. PDE5 inhibition suppresses serotonin signalling and consequent cellular proliferation in primary cultured pulmonary artery smooth muscle cells |
713199 |
| 3.1.4.35 | malfunction |
identification of a Pgamma-depleted PDE as Palphabetagamma, detailed overview |
716199 |
| 3.1.4.35 | malfunction |
inhibition of cGMP phosphodiesterase 5 suppresses matrix metalloproteinase-2 production in pulmonary artery smooth muscle cells |
711773 |
| 3.1.4.35 | malfunction |
inhibition of PDE-5 slows cGMP degradation, leading to increased levels of cGMP and greater blood flow through the corpus cavernosum when nitric oxide is released during sexual stimulation, PDE-5 inhibitors have little effect on corpus cavernosum blood flow |
711841 |
| 3.1.4.35 | malfunction |
PDE5 inhibitors may elevate the expression of nNOS by relaxing the smooth muscle of the ureteral wall through suppression of fibrosis |
713572 |
| 3.1.4.35 | metabolism |
during rod phototransduction, cGMP and Ca2+ are regulated by PDE6, guanylate cyclase, and cGMP-gated Na+/Ca2+ channels. The level of cGMP is controlled by opposing activities of PDE6 and guanylate cyclase and, at sufficiently high levels, Na+/Ca2+ channels open to allow increased Ca2+ influx into the rod outer segment |
-, 715716 |
