EC Number   |
General Information |
Reference |
|---|
   2.8.2.2 | evolution |
gene structure and genomic organization of each cynomolgus SULTs are similar to those of the human orthologues. SULT1A3 and SULT1A4 have arisen from the single gene by gene duplication and encode the same protein. Tissue distribution and sbstrate specificities of SULTS from humans and Cynomolgus macaques, overview |
760542 |
| 2.8.2.2 | evolution |
gene structure and genomic organization of each cynomolgus SULTs are similar to those of the human orthologues. SULT1B1 and SULT1E1 form a gene cluster |
760542 |
| 2.8.2.2 | evolution |
gene structure and genomic organization of each cynomolgus SULTs are similar to those of the human orthologues. SULT1B1 and SULT1E1 formed a gene cluster. Tissue distribution and sbstrate specificities of SULTS from humans and Cynomolgus macaques, overview |
760542 |
| 2.8.2.2 | evolution |
gene structure and genomic organization of each cynomolgus SULTs are similar to those of the human orthologues. SULT1C2v1, SULT1C2v2, and SULT1C4 form a gene cluster with a SULT1C3-like gene. Tissue distribution and sbstrate specificities of SULTS from humans and Cynomolgus macaques, overview |
760542 |
| 2.8.2.2 | evolution |
gene structure and genomic organization of each cynomolgus SULTs are similar to those of the human orthologues. The cynomolgus SULT1C2v2 is highly homologous to human SULT1C2P1 (pseudogene). Tissue distribution and sbstrate specificities of SULTS from humans and Cynomolgus macaques, overview |
760542 |
| 2.8.2.2 | evolution |
gene structure and genomic organization of each cynomolgus SULTs are similar to those of the human orthologues. Tissue distribution and sbstrate specificities of SULTS from humans and Cynomolgus macaques, overview |
760542 |
| 2.8.2.2 | evolution |
human cytosolic sulfotransferases (hSULTs) canbe classified into four families (hSULT1, hSULT2, hSULT4, and hSULT6) based on sequence similarity |
760274 |
| 2.8.2.2 | evolution |
more than 160 cSNPs have been reported for SULT2A1. SULT2A1 SNPs Ala63Pro, Lys227Glu, and Ala261Thr have only been found in African-American populations, and these might explain the interethnic differences in SULT2A1 activity |
761169 |
| 2.8.2.2 | malfunction |
downregulation or ablation of Sult2B1b enhances the gluconeogenic activity of HNF4alpha, which may cause increased acetylation of HNF4alpha as a result of decreased expression of the HNF4alpha deacetylase sirtuin 1 (Sirt1). Sult2B1b-/- mice exhibit elevated fasting blood glucose levels. Thiocholesterol is a hydrolysis-resistant derivative of cholesterol, which shows superior activity to that of the native cholesterol in inhibiting gluconeogenesis and improving insulin sensitivity in high-fat-diet-induced diabetic mice |
761897 |
| 2.8.2.2 | malfunction |
Functional analysis has revealed that the nonsynonymous SNPs Met57Thr, Glu186Val, Ala63Pro, and Lys227Glu result in decreased SULT2A1 activity when expressed in COS-1 cells |
761169 |
