EC Number   |
General Information |
Reference |
|---|
   2.3.1.82 | physiological function |
a total of 3,964 aac(6')-Ib sequences are present in the genomes of 34 bacterial genera, mostly found in Gammaproteobacteria. Among these, aac(6')-Ib-cr variants, known to confer fluoroquinolone resistance, are increasingly detected in bacterial genomes and most abundant in the genera Klebsiella and Escherichia. The proportions of the cr variant are higher in animal and environmental isolates than in human isolates, among which the variant is dominant (over 50%) in the genomes of intestinal, rectal, and fecal origins. The prevalence of the cr variant is associated with the occurrence of a variant with the mutation L117 (IbL) |
756795 |
| 2.3.1.82 | physiological function |
Escherichia coli transformed with a plasmid containing aac(6')-Iaj exhibits decreased susceptibility to arbekacin, dibekacin, neomycin, netilmicin, sisomicin, and tobramycin |
-, 735443 |
| 2.3.1.82 | physiological function |
Escherichia coli transformed with a plasmid containing aac(6')-Iak exhibits decreased susceptibility to arbekacin, dibekacin, neomycin, netilmicin, sisomicin, and tobramycin |
-, 735445 |
| 2.3.1.82 | physiological function |
the enzyme confers high-level heterologous resistance to the aminoglycosides gentamicin C, sisomicin, and tobramycin |
755693 |
| 2.3.1.82 | physiological function |
when expressed in the Escherichia coli JM83 strain, AAC(6')-Im produces resistance to a wide range of clinically important 4,6-disubstituted aminoglycosides with minimal inhibitory concentration values 8-128fold above those for the recipient strain |
757594 |
