EC Number |
Reaction |
Reference |
---|
2.4.1.101 | UDP-N-acetyl-alpha-D-glucosamine + Man5GlcNAc2-[protein] = UDP + Man5GlcNAc3-[protein] |
active site |
488376, 488380 |
2.4.1.101 | UDP-N-acetyl-alpha-D-glucosamine + Man5GlcNAc2-[protein] = UDP + Man5GlcNAc3-[protein] |
D212 is the central residue of the DxD motif, conserved throughout all species |
488380 |
2.4.1.101 | UDP-N-acetyl-alpha-D-glucosamine + Man5GlcNAc2-[protein] = UDP + Man5GlcNAc3-[protein] |
DxD motif |
488376 |
2.4.1.101 | UDP-N-acetyl-alpha-D-glucosamine + Man5GlcNAc2-[protein] = UDP + Man5GlcNAc3-[protein] |
mechanism |
488368 |
2.4.1.101 | UDP-N-acetyl-alpha-D-glucosamine + Man5GlcNAc2-[protein] = UDP + Man5GlcNAc3-[protein] |
modeling study provides detailed insight into the mechanism of the GlcNAc transfer |
674191 |
2.4.1.101 | UDP-N-acetyl-alpha-D-glucosamine + Man5GlcNAc2-[protein] = UDP + Man5GlcNAc3-[protein] |
ordered sequential bi bi mechanism |
488376 |
2.4.1.101 | UDP-N-acetyl-alpha-D-glucosamine + Man5GlcNAc2-[protein] = UDP + Man5GlcNAc3-[protein] |
R represents the reminder of the N-linked oligosaccharide in the glycoprotein acceptor. Note that this enzyme acts before N-acetylglucosaminyltransferase II, III, IV, V and VI. |
- |
2.4.1.101 | UDP-N-acetyl-alpha-D-glucosamine + Man5GlcNAc2-[protein] = UDP + Man5GlcNAc3-[protein] |
R303 is important for enzyme activity, conserved throughout all species |
488380 |
2.4.1.101 | UDP-N-acetyl-alpha-D-glucosamine + Man5GlcNAc2-[protein] = UDP + Man5GlcNAc3-[protein] |
SGC domain of SGC superfamily |
488376 |