EC Number   |
Application |
Reference |
|---|
    4.4.1.5 | analysis |
flow cytometry method for GLO-1 detection in human leukocytes isolated from peripheral blood samples to investigate GLO-1 expression in leukocyte subsets from type 1 and 2 diabetes mellitus patients. Expression index of GLO-1-positive cells is slightly increased in mononuclear leukocytes from diabetic patients. This result correlates with the increase in GLO-1 activity in the whole blood samples of type 2 diabetes patients |
714667 |
| 4.4.1.5 | analysis |
practical experiments for students to determine the effect of exposure to oxidative stress conditions on yeast glyoxalase I, investigation of kinetic parameters |
690845 |
| 4.4.1.5 | drug development |
beta-ketoesters function as a possible zinc-chelating component of Glx-I inhibitors |
678673 |
| 4.4.1.5 | drug development |
cancer therapy, inhibitors of the glyoxalase system would be expected to suppress the growth of cancer cells and could find clinical use as anticancer drug |
692048 |
| 4.4.1.5 | drug development |
design of a metabolically stable glyoxalase-I inhibitor, which may be useful in potentiating the antitumor activity of alpha-ketoaldehydes |
678641 |
| 4.4.1.5 | drug development |
difference of the substrate specificity of the human and the Leishmania enzyme could be used for designing selective inhibitors against the parasite |
663884 |
| 4.4.1.5 | drug development |
mutually exclusive substrate specificities and substantial differences between the active sites of the Leishmania major and human GLO1 enzymes indicate that selective inhibition of LmGLO1 may be possible |
681984 |
| 4.4.1.5 | drug development |
the enzyme is a promising drug target, since the functional monomeric Glo1 from Plasmodium falciparum differs significantly from its human homologue |
729176 |
| 4.4.1.5 | medicine |
decrease of glyoxalase I expression with increasing Alzheimers disease stage might be one reason for methylglyoxal-induced neuronal impairment, apoptosis, and advanced glycation end formation in plaques and tangles |
682102 |
| 4.4.1.5 | medicine |
flow cytometry method for GLO-1 detection in human leukocytes isolated from peripheral blood samples to investigate GLO-1 expression in leukocyte subsets from type 1 and 2 diabetes mellitus patients. Expression index of GLO-1-positive cells is slightly increased in mononuclear leukocytes from diabetic patients. This result correlates with the increase in GLO-1 activity in the whole blood samples of type 2 diabetes patients |
714667 |
